Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

B. Yoo, S. H. Lee, S. Y. Kim, A. Y. Leem, K. S. Chung, E. Y. Kim, J. Y. Jung, Y. A. Kang, M. S. Park, J. Chang, Y. S. Kim, Y. Park

Research output: Contribution to journalArticlepeer-review


O B J E C T I V E: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea. D E S I G N: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of,95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants. R E S U L T S: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males. C O N C L U S I O N: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.

Original languageEnglish
Pages (from-to)1228-1234
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number11
Publication statusPublished - 2019 Nov 1

Bibliographical note

Funding Information:
The Ansung-Ansan cohort study is an ongoing prospective study, which started in 2001. It is supported by the National Genome Research Institute (Korea Centers for Disease Control and Prevention, Cheongju, Korea), and aims to investigate the health status of and chronic disease in Koreans. The study forms part of the Korean Genome and Epidemiology Study (KoGES), a large, community-based survey. Detailed information on the study design and procedures has been published.13 We used the Ansung-Ansan cohort data for our analysis.

Publisher Copyright:
© 2019 The Union

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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