Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

B. Yoo; S. H. Lee; S. Y. Kim; A. Y. Leem; K. S. Chung; E. Y. Kim; J. Y. Jung; Y. A. Kang; M. S. Park; J. Chang; Y. S. Kim; Y. Park

doi:10.5588/ijtld.18.0848

Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

B. Yoo, S. H. Lee, S. Y. Kim, A. Y. Leem, K. S. Chung, E. Y. Kim, J. Y. Jung, Y. A. Kang, M. S. Park, J. Chang, Y. S. Kim, Y. Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

O B J E C T I V E: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea. D E S I G N: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV₁:FVC) of,95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants. R E S U L T S: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV₁ and FVC decreased. A higher FEV₁:FVC ratio was associated with lower hs-CRP levels in males. C O N C L U S I O N: Higher hs-CRP levels were associated with decreased FEV₁ and FVC in a general population of Korea. The FEV₁:FVC ratio decreased with an increase in the hs-CRP level in males.

Original language	English
Pages (from-to)	1228-1234
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	23
Issue number	11
DOIs	https://doi.org/10.5588/ijtld.18.0848
Publication status	Published - 2019 Nov 1

Bibliographical note

Funding Information:
The Ansung-Ansan cohort study is an ongoing prospective study, which started in 2001. It is supported by the National Genome Research Institute (Korea Centers for Disease Control and Prevention, Cheongju, Korea), and aims to investigate the health status of and chronic disease in Koreans. The study forms part of the Korean Genome and Epidemiology Study (KoGES), a large, community-based survey. Detailed information on the study design and procedures has been published.13 We used the Ansung-Ansan cohort data for our analysis.

Publisher Copyright:
© 2019 The Union

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.18.0848

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Yoo, B., Lee, S. H., Kim, S. Y., Leem, A. Y., Chung, K. S., Kim, E. Y., Jung, J. Y., Kang, Y. A., Park, M. S., Chang, J., Kim, Y. S., & Park, Y. (2019). Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea. International Journal of Tuberculosis and Lung Disease, 23(11), 1228-1234. https://doi.org/10.5588/ijtld.18.0848

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abstract = "O B J E C T I V E: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea. D E S I G N: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of,95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants. R E S U L T S: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males. C O N C L U S I O N: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.",

author = "B. Yoo and Lee, {S. H.} and Kim, {S. Y.} and Leem, {A. Y.} and Chung, {K. S.} and Kim, {E. Y.} and Jung, {J. Y.} and Kang, {Y. A.} and Park, {M. S.} and J. Chang and Kim, {Y. S.} and Y. Park",

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T1 - Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

AU - Yoo, B.

AU - Lee, S. H.

AU - Kim, S. Y.

AU - Leem, A. Y.

AU - Chung, K. S.

AU - Kim, E. Y.

AU - Jung, J. Y.

AU - Kang, Y. A.

AU - Park, M. S.

AU - Chang, J.

AU - Kim, Y. S.

AU - Park, Y.

N1 - Funding Information: The Ansung-Ansan cohort study is an ongoing prospective study, which started in 2001. It is supported by the National Genome Research Institute (Korea Centers for Disease Control and Prevention, Cheongju, Korea), and aims to investigate the health status of and chronic disease in Koreans. The study forms part of the Korean Genome and Epidemiology Study (KoGES), a large, community-based survey. Detailed information on the study design and procedures has been published.13 We used the Ansung-Ansan cohort data for our analysis. Publisher Copyright: © 2019 The Union

PY - 2019/11/1

Y1 - 2019/11/1

N2 - O B J E C T I V E: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea. D E S I G N: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of,95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants. R E S U L T S: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males. C O N C L U S I O N: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.

AB - O B J E C T I V E: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea. D E S I G N: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of,95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants. R E S U L T S: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males. C O N C L U S I O N: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.

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Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

Abstract

Bibliographical note

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UN SDGs

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