Relationship between changes in polyunsaturated fatty acids and aging-related arterial stiffness in overweight subjects 50 years or older over a 3-year period

Seung Han Baek, Minkyung Kim, Minjoo Kim, Hye Jin Yoo, Ayoung Lee, Minjae Ji, Min Song, Jong Ho Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background Although aging-related elastic arterial stiffness is an independent indicator of cardiovascular risk, the roles of polyunsaturated fatty acids in this condition remain uncertain. Objective This prospective study examined the relationships of aging, persist overweight and plasma fatty acids with arterial stiffening over 3 years. Methods We divided a cohort of 179 healthy, nonhypertensive subjects (aged ≥50 years) into 2 groups: a normal-weight group (18.5 kg/m2 ≤ body mass index [BMI] < 25 kg/m2, n = 103) and an overweight group (25 kg/m2 ≤ BMI< 30 kg/m2, n = 76). Brachial-ankle pulse wave velocity (ba-PWV) and plasma fatty acids were measured at baseline and after 3 years. Results After 3 years, the overweight group showed greater increases in systolic and diastolic blood pressure, insulin, homeostasis model assessment-Insulin resistance index and ba-PWV values (P = .009) than the normal-weight group. In addition, greater reductions in eicosapentaenoic acid (C20:3, n-3, EPA; P = .009) and the EPA/arachidonic acid (C20:4, n-6, AA) ratio (P = .001) were found in the overweight group. Multivariate analyses revealed that changes in (Δ) ba-PWV were significantly and positively associated with baseline BMI values and ΔAA/linoleic acid ratios (C18:2, n-6, LA) and negatively associated with ΔEPA/AA ratios. In a subanalysis using baseline BMI values, Δba-PWV correlated strongly and negatively with ΔEPA/AA ratios (r = −0.595, P < .001) and positively with ΔAA/LA ratios (r = 0.455, P < .001) in the overweight group. Conclusion This study suggests that the persistence of overweight over 3 years in subjects ≥50 years old is associated with faster arterial stiffening than is observed in normal-weight subjects and that this stiffening is independently associated with increases in AA/LA and decreases in EPA/AA ratios.

Original languageEnglish
Pages (from-to)185-194.e2
JournalJournal of Clinical Lipidology
Issue number1
Publication statusPublished - 2017 Jan 1

Bibliographical note

Funding Information:
This study was funded by the Bio-Synergy Research Project (NRF-2012M3A9C4048762, NRF-2013M3A9C4078138) and the Mid-Career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT, and Future Planning through the National Research Foundation, Republic of Korea.

Publisher Copyright:
© 2016 National Lipid Association

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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