Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system

Minkyung Lee, Young Hoon Ryu, Won Gil Cho, Yeo Wool Kang, Soo Jin Lee, Tae Joo Jeon, Chulhyoung Lyoo, Chul Hoon Kim, Dong Goo Kim, Kyochul Lee, Tae Hyun Choi, Jae Yong Choi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Depression frequently accompanies in Parkinson's disease (PD). Previous research suggested that dopamine (DA) and serotonin systems are closely linked with depression in PD. However, comprehensive studies about the relationship between these two neurotransmitter systems are limited. Therefore, the purpose of this study is to evaluate the effect of dopaminergic destruction on the serotonin system. The interconnection between motor and depression was also examined. Two PET scans were performed in the 6-hydroxydopamine (6-OHDA) lesioned and sham operated rats: [18F]FP-CIT for DA transporters and [18F]Mefway for serotonin 1A (5-HT1A) receptors. Here, 6-OHDA is a neurotoxin for dopaminergic neurons. Behavioral tests were used to evaluate the severity of symptoms: rotational number for motor impairment and immobility time, acquired from the forced swim test for depression. Region-of-interests were drawn in the striatum and cerebellum for the DA system and hippocampus and cerebellum for the 5-HT system. The cerebellum was chosen as a reference region. Nondisplaceable binding potential in the striatum and hippocampus were compared between 6-OHDA and sham groups. As a result, the degree of DA depletion was negatively correlated with rotational behavior (R2=0.79, P=0.003). In 6-OHDA lesioned rats, binding values for 5-HT1A receptors was 22% lower than the sham operated group. This decrement of 5-HT1A receptor binding was also correlated with the severity of depression (R2=0.81, P=0.006). Taken together, this research demonstrated that the destruction of dopaminergic system causes the reduction of the serotonergic system resulting in the expression of depressive behavior. The degree of dopaminergic dysfunction was positively correlated with the impairment of the serotonin system. Severity of motor symptoms was also closely related to depressive behavior.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalSynapse
Volume69
Issue number9
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Oxidopamine
Dopamine
Serotonin
Receptor, Serotonin, 5-HT1A
Depression
Cerebellum
Parkinson Disease
Hippocampus
Dopamine Plasma Membrane Transport Proteins
Dopaminergic Neurons
Neurotoxins
Research
Positron-Emission Tomography
Neurotransmitter Agents

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Lee, M., Ryu, Y. H., Cho, W. G., Kang, Y. W., Lee, S. J., Jeon, T. J., ... Choi, J. Y. (2015). Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system. Synapse, 69(9), 453-460. https://doi.org/10.1002/syn.21834
Lee, Minkyung ; Ryu, Young Hoon ; Cho, Won Gil ; Kang, Yeo Wool ; Lee, Soo Jin ; Jeon, Tae Joo ; Lyoo, Chulhyoung ; Kim, Chul Hoon ; Kim, Dong Goo ; Lee, Kyochul ; Choi, Tae Hyun ; Choi, Jae Yong. / Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system. In: Synapse. 2015 ; Vol. 69, No. 9. pp. 453-460.
@article{d9eb3505a4b644e3b4c64e205e77e496,
title = "Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system",
abstract = "Depression frequently accompanies in Parkinson's disease (PD). Previous research suggested that dopamine (DA) and serotonin systems are closely linked with depression in PD. However, comprehensive studies about the relationship between these two neurotransmitter systems are limited. Therefore, the purpose of this study is to evaluate the effect of dopaminergic destruction on the serotonin system. The interconnection between motor and depression was also examined. Two PET scans were performed in the 6-hydroxydopamine (6-OHDA) lesioned and sham operated rats: [18F]FP-CIT for DA transporters and [18F]Mefway for serotonin 1A (5-HT1A) receptors. Here, 6-OHDA is a neurotoxin for dopaminergic neurons. Behavioral tests were used to evaluate the severity of symptoms: rotational number for motor impairment and immobility time, acquired from the forced swim test for depression. Region-of-interests were drawn in the striatum and cerebellum for the DA system and hippocampus and cerebellum for the 5-HT system. The cerebellum was chosen as a reference region. Nondisplaceable binding potential in the striatum and hippocampus were compared between 6-OHDA and sham groups. As a result, the degree of DA depletion was negatively correlated with rotational behavior (R2=0.79, P=0.003). In 6-OHDA lesioned rats, binding values for 5-HT1A receptors was 22{\%} lower than the sham operated group. This decrement of 5-HT1A receptor binding was also correlated with the severity of depression (R2=0.81, P=0.006). Taken together, this research demonstrated that the destruction of dopaminergic system causes the reduction of the serotonergic system resulting in the expression of depressive behavior. The degree of dopaminergic dysfunction was positively correlated with the impairment of the serotonin system. Severity of motor symptoms was also closely related to depressive behavior.",
author = "Minkyung Lee and Ryu, {Young Hoon} and Cho, {Won Gil} and Kang, {Yeo Wool} and Lee, {Soo Jin} and Jeon, {Tae Joo} and Chulhyoung Lyoo and Kim, {Chul Hoon} and Kim, {Dong Goo} and Kyochul Lee and Choi, {Tae Hyun} and Choi, {Jae Yong}",
year = "2015",
month = "1",
day = "1",
doi = "10.1002/syn.21834",
language = "English",
volume = "69",
pages = "453--460",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley-Liss Inc.",
number = "9",

}

Lee, M, Ryu, YH, Cho, WG, Kang, YW, Lee, SJ, Jeon, TJ, Lyoo, C, Kim, CH, Kim, DG, Lee, K, Choi, TH & Choi, JY 2015, 'Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system', Synapse, vol. 69, no. 9, pp. 453-460. https://doi.org/10.1002/syn.21834

Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system. / Lee, Minkyung; Ryu, Young Hoon; Cho, Won Gil; Kang, Yeo Wool; Lee, Soo Jin; Jeon, Tae Joo; Lyoo, Chulhyoung; Kim, Chul Hoon; Kim, Dong Goo; Lee, Kyochul; Choi, Tae Hyun; Choi, Jae Yong.

In: Synapse, Vol. 69, No. 9, 01.01.2015, p. 453-460.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system

AU - Lee, Minkyung

AU - Ryu, Young Hoon

AU - Cho, Won Gil

AU - Kang, Yeo Wool

AU - Lee, Soo Jin

AU - Jeon, Tae Joo

AU - Lyoo, Chulhyoung

AU - Kim, Chul Hoon

AU - Kim, Dong Goo

AU - Lee, Kyochul

AU - Choi, Tae Hyun

AU - Choi, Jae Yong

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Depression frequently accompanies in Parkinson's disease (PD). Previous research suggested that dopamine (DA) and serotonin systems are closely linked with depression in PD. However, comprehensive studies about the relationship between these two neurotransmitter systems are limited. Therefore, the purpose of this study is to evaluate the effect of dopaminergic destruction on the serotonin system. The interconnection between motor and depression was also examined. Two PET scans were performed in the 6-hydroxydopamine (6-OHDA) lesioned and sham operated rats: [18F]FP-CIT for DA transporters and [18F]Mefway for serotonin 1A (5-HT1A) receptors. Here, 6-OHDA is a neurotoxin for dopaminergic neurons. Behavioral tests were used to evaluate the severity of symptoms: rotational number for motor impairment and immobility time, acquired from the forced swim test for depression. Region-of-interests were drawn in the striatum and cerebellum for the DA system and hippocampus and cerebellum for the 5-HT system. The cerebellum was chosen as a reference region. Nondisplaceable binding potential in the striatum and hippocampus were compared between 6-OHDA and sham groups. As a result, the degree of DA depletion was negatively correlated with rotational behavior (R2=0.79, P=0.003). In 6-OHDA lesioned rats, binding values for 5-HT1A receptors was 22% lower than the sham operated group. This decrement of 5-HT1A receptor binding was also correlated with the severity of depression (R2=0.81, P=0.006). Taken together, this research demonstrated that the destruction of dopaminergic system causes the reduction of the serotonergic system resulting in the expression of depressive behavior. The degree of dopaminergic dysfunction was positively correlated with the impairment of the serotonin system. Severity of motor symptoms was also closely related to depressive behavior.

AB - Depression frequently accompanies in Parkinson's disease (PD). Previous research suggested that dopamine (DA) and serotonin systems are closely linked with depression in PD. However, comprehensive studies about the relationship between these two neurotransmitter systems are limited. Therefore, the purpose of this study is to evaluate the effect of dopaminergic destruction on the serotonin system. The interconnection between motor and depression was also examined. Two PET scans were performed in the 6-hydroxydopamine (6-OHDA) lesioned and sham operated rats: [18F]FP-CIT for DA transporters and [18F]Mefway for serotonin 1A (5-HT1A) receptors. Here, 6-OHDA is a neurotoxin for dopaminergic neurons. Behavioral tests were used to evaluate the severity of symptoms: rotational number for motor impairment and immobility time, acquired from the forced swim test for depression. Region-of-interests were drawn in the striatum and cerebellum for the DA system and hippocampus and cerebellum for the 5-HT system. The cerebellum was chosen as a reference region. Nondisplaceable binding potential in the striatum and hippocampus were compared between 6-OHDA and sham groups. As a result, the degree of DA depletion was negatively correlated with rotational behavior (R2=0.79, P=0.003). In 6-OHDA lesioned rats, binding values for 5-HT1A receptors was 22% lower than the sham operated group. This decrement of 5-HT1A receptor binding was also correlated with the severity of depression (R2=0.81, P=0.006). Taken together, this research demonstrated that the destruction of dopaminergic system causes the reduction of the serotonergic system resulting in the expression of depressive behavior. The degree of dopaminergic dysfunction was positively correlated with the impairment of the serotonin system. Severity of motor symptoms was also closely related to depressive behavior.

UR - http://www.scopus.com/inward/record.url?scp=84937680044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937680044&partnerID=8YFLogxK

U2 - 10.1002/syn.21834

DO - 10.1002/syn.21834

M3 - Article

VL - 69

SP - 453

EP - 460

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 9

ER -