Relationship between hearing loss and dementia differs according to the underlying mechanism

Jinsei Jung, Seong Hoon Bae, Ji Hyuk Han, Sang Hyun Kwak, Gi Sung Nam, Phil Hyu Lee, Young Ho Sohn, Mijin Yun, Byung Seok Ye

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Abstract

Background and Purpose The associations between hearing loss (HL) and the mechanisms underlying cognitive impairment (CI) remain unclear. We evaluated the effects of clinical factors, vascular magnetic resonance imaging (MRI) markers, and CI mechanisms on HL. Methods In total, 112 patients with CI (59% demented) and subjective HL prospectively underwent MRI, amyloid positron-emission tomography (PET), hearing evaluations, and neuropsychological tests including a language comprehension test. Patients were categorized into pure-Alzheimer’s disease-related CI (ADCI), pure-Lewy-body disease-related CI (LBCI), mixed-ADCI/LBCI, and non-ADCI/LBCI groups based on clinical features and PET biomarkers. Results The risk of peripheral HL [defined as a pure-tone average (PTA) threshold >40 dB] was higher in the pure-LBCI group than in the pure-ADCI and mixed-ADCI/LBCI groups, and lower in the presence of ADCI. The non-ADCI/LBCI group had the most-severe vascular MRI markers and showed a higher risk of peripheral HL than did the pure-ADCI and mixed-ADCI/LBCI groups. While the pure-LBCI group had a higher risk of comprehension dysfunction than the pure-ADCI group regardless of the PTA and the score on the Korean version of the Mini Mental State Examination (K-MMSE), those in the pure-LBCI group even with a better K-MMSE score had a risk of comprehension dysfunction comparable to that in the mixed-ADCI/LBCI group due to a worse PTA. Conclusions Peripheral HL could be associated with the absence of significant β-amyloid deposition in patients with CI and characteristic of the pure-LBCI and non-ADCI/LBCI groups.

Original languageEnglish
Pages (from-to)290-299
Number of pages10
JournalJournal of Clinical Neurology (Korea)
Volume17
Issue number2
DOIs
Publication statusPublished - 2021 Apr

Bibliographical note

Funding Information:
This research was supported by a Yonsei University College of Medicine grant funded by the Dongwha Industry (6-2016-0128 to J.J.), a faculty research grant from Yonsei University College of Medicine (6-2018-0052 to S.Y.B.), and the research program through the National Research Foundation of Korea (NRF) funded by the Korea government (2017M3A9E8029721 to J.J.). These funding bodies played no role in the study design, collection, analysis and interpretation of data, writing of the report, or the decision to submit the article for publication.

Publisher Copyright:
© 2021 Korean Neurological Association.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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