Relationship between myocardial extracellular space expansion estimated with post-contrast T1 mapping mri and left ventricular remodeling and neurohormonal activation in patients with dilated cardiomyopathy

Ji Hyun Yoon, Jung Woo Son, Hyemoon Chung, Chul Hwan Park, Young Jin Kim, Hyuk Jae Chang, Geu Ru Hong, Tae Hoon Kim, Jong Won Ha, Byoung Wook Choi, Se Joong Rim, Namsik Chung, Eui Young Choi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Objective: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). Materials and Methods: Fifty-nine patients with DCM (mean age, 55 ± 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients. Results: The mean LV ejection fraction was 24 ± 9% and the post-T1 value was 254.5 ± 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s’), peak late diastolic velocity of the mitral annulus (a’), the diastolic elastance index (Ed, [E/e’]/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (β = -0.351, p = 0.016) and the LV mass/volume ratio (β = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NTproBNP was independently correlated with the T1 values (β = -0.339, p = 0.017). Conclusion: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.

Original languageEnglish
Pages (from-to)1153-1162
Number of pages10
JournalKorean journal of radiology
Volume16
Issue number5
DOIs
Publication statusPublished - 2015 Sep 1

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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