Relationship between non-alcoholic fatty liver disease and pulmonary function

D. H. Jung, J. Y. Shim, H. R. Lee, B. S. Moon, B. J. Park, Yongjae Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: It has been observed that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease and insulin resistance. Pulmonary function is also known to be related with cardiovascular disease and metabolic syndrome. Aims: The objective of this study was to investigate the association between NAFLD and pulmonary function. Methods: We performed a cross-sectional study to examine the association of NAFLD based on abdominal sonographic findings and pulmonary function in 2119 Korean men between the ages of 30 and 75. Forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1) were compared according to the presence of NAFLD. Univariate and multivariate logistic regression analyses were conducted to evaluate the relationship of NAFLD with FVC and FEV1 as pulmonary function tests. Results: The subjects with NAFLD had lower FVC and FEV1 than their non-steatotic counterparts, and FVC and FEV1 gradually decreased according to the grade of hepatic steatosis. After adjusting for age, body mass index, smoking status, blood pressure, fasting plasma glucose, total cholesterol, hypertension, diabetes, triglyceride and high-density lipoprotein cholesterol, the FVC and FEV1 were found to be inversely associated with the presence of NAFLD. Conclusion: NAFLD was independently associated with reduced pulmonary function, and the severity of NAFLD was inversely correlated with pulmonary function.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalInternal Medicine Journal
Volume42
Issue number5
DOIs
Publication statusPublished - 2012 May 1

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Lung
Vital Capacity
Forced Expiratory Volume
Cardiovascular Diseases
Non-alcoholic Fatty Liver Disease
Disease Resistance
Respiratory Function Tests
HDL Cholesterol
Insulin Resistance
Fasting
Triglycerides
Body Mass Index
Cross-Sectional Studies
Logistic Models
Smoking
Cholesterol
Regression Analysis
Blood Pressure
Hypertension
Glucose

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Jung, D. H. ; Shim, J. Y. ; Lee, H. R. ; Moon, B. S. ; Park, B. J. ; Lee, Yongjae. / Relationship between non-alcoholic fatty liver disease and pulmonary function. In: Internal Medicine Journal. 2012 ; Vol. 42, No. 5. pp. 541-546.
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Relationship between non-alcoholic fatty liver disease and pulmonary function. / Jung, D. H.; Shim, J. Y.; Lee, H. R.; Moon, B. S.; Park, B. J.; Lee, Yongjae.

In: Internal Medicine Journal, Vol. 42, No. 5, 01.05.2012, p. 541-546.

Research output: Contribution to journalArticle

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