Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults

A cross-sectional study

Ji Young Kim, Choae Lee, Minsuk Oh, Jee Aee Im, Ji Won Lee, Sang Hui Chu, Hyangkyu Lee, Justin Y. Jeon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. Methods: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. Results: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33). Conclusions: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalClinica Chimica Acta
Volume458
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Liver
Insulin Resistance
Cross-Sectional Studies
Insulin
Obesity
Adiposity
Non-alcoholic Fatty Liver Disease
Health
Health Promotion
Regression analysis
Logistics
Fasting
Logistic Models
Regression Analysis
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{b33b06c1b24c406cace303c2f60b3e50,
title = "Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults: A cross-sectional study",
abstract = "Background: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. Methods: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. Results: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95{\%} CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95{\%} CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95{\%} CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95{\%} CI: 1.64-7.33). Conclusions: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.",
author = "Kim, {Ji Young} and Choae Lee and Minsuk Oh and Im, {Jee Aee} and Lee, {Ji Won} and Chu, {Sang Hui} and Hyangkyu Lee and Jeon, {Justin Y.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.cca.2016.03.018",
language = "English",
volume = "458",
pages = "12--17",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",

}

Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults : A cross-sectional study. / Kim, Ji Young; Lee, Choae; Oh, Minsuk; Im, Jee Aee; Lee, Ji Won; Chu, Sang Hui; Lee, Hyangkyu; Jeon, Justin Y.

In: Clinica Chimica Acta, Vol. 458, 01.07.2016, p. 12-17.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults

T2 - A cross-sectional study

AU - Kim, Ji Young

AU - Lee, Choae

AU - Oh, Minsuk

AU - Im, Jee Aee

AU - Lee, Ji Won

AU - Chu, Sang Hui

AU - Lee, Hyangkyu

AU - Jeon, Justin Y.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. Methods: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. Results: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33). Conclusions: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.

AB - Background: We investigated the independent and combined impact of obesity and nonalcoholic fatty liver disease (NAFLD) on components and prevalence of metabolic syndrome in Korean adults. Methods: This study included 1695 adults (500 males and 1,195 females), who took part in a regular health check-up at the community-based health promotion center. Participants were divided according to degree of adiposity and the presence of NAFLD. The components and prevalence of metabolic syndrome were compared. Results: Fasting glucose was significantly higher in nonobese participants with NAFLD compared to obese participants without NAFLD. Logistic regression analysis revealed that the presence of NAFLD was associated with 3.63 times increased prevalence of metabolic syndrome (95% CI: 1.21-10.86) while obesity without NAFLD was associated with 3.84 times increased prevalence of metabolic syndrome (95% CI: 1.57-9.36) in male. In female, the presence of NAFLD was associated with 5.56 times higher prevalence of metabolic syndrome (95% CI: 2.53-12.23) while obesity without NAFLD had 3.46 times increased prevalence of metabolic syndrome (95% CI: 1.64-7.33). Conclusions: NAFLD is associated with the prevalence of metabolic syndrome, independent of adiposity. In females, NAFLD may be a more important factor than obesity for risk of metabolic syndrome.

UR - http://www.scopus.com/inward/record.url?scp=84966318363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966318363&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2016.03.018

DO - 10.1016/j.cca.2016.03.018

M3 - Article

VL - 458

SP - 12

EP - 17

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -