Relationship between nutrition factors and osteopenia: Effects of experimental diets on immature bone quality

D. G. Woo, B. Y. Lee, D. Lim, H. S. Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To investigate the influence of experimental diets on morphological and mechanical characteristics of immature bone, this study thoroughly examined the nutrition-bone connection. A non-destructive evaluation method involving high-resolution in-vivo micro-computed tomography and finite element (FE) analysis was used to investigate the relationship between obesity and osteopenia-two disorders of body composition. Correlation of nutritional deficiency with bone characteristics was also investigated. Some recent studies have shown that both obesity and osteopenia share several common genetic and environmental factors. However, there have been few studies correlating these pathologies in-vivo from a structural and biomechanical point of view. In the present study, detailed changes in morphological and mechanical characteristics of trabecular bone architecture were detected and tracked by longitudinal studies of morphometric parameters and simulated compression testing. Rats were randomized into three groups: overeaten diet (OD) for formation of obesity, normal diet (ND), and restricted diet (RD) in which rats received 65% of the normal diet. In the OD and ND groups, all structural parameters changed significantly (p<0.05). The degree of alteration in the structural parameters of the ND group was similar to that of the RD group (p<0.05). In simulated compression tests using FE models, the effective modulus of the OD group significantly decreased, depending on measuring time (p<0.05), whereas that of the ND and RD groups significantly increased (p>0.05). The key finding of the present study is that fat mass is morphologically and mechanically inversely correlated with bone mass when the mechanical loading effects of greater body weight on bone mass are applied.

Original languageEnglish
Pages (from-to)1102-1107
Number of pages6
JournalJournal of Biomechanics
Volume42
Issue number8
DOIs
Publication statusPublished - 2009 May 29

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Metabolic Bone Diseases
Nutrition
Bone
Diet
Bone and Bones
Obesity
Rats
Finite Element Analysis
Compression testing
Body Composition
Malnutrition
Pathology
Oils and fats
Longitudinal Studies
Tomography
Fats
Body Weight
Finite element method
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

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abstract = "To investigate the influence of experimental diets on morphological and mechanical characteristics of immature bone, this study thoroughly examined the nutrition-bone connection. A non-destructive evaluation method involving high-resolution in-vivo micro-computed tomography and finite element (FE) analysis was used to investigate the relationship between obesity and osteopenia-two disorders of body composition. Correlation of nutritional deficiency with bone characteristics was also investigated. Some recent studies have shown that both obesity and osteopenia share several common genetic and environmental factors. However, there have been few studies correlating these pathologies in-vivo from a structural and biomechanical point of view. In the present study, detailed changes in morphological and mechanical characteristics of trabecular bone architecture were detected and tracked by longitudinal studies of morphometric parameters and simulated compression testing. Rats were randomized into three groups: overeaten diet (OD) for formation of obesity, normal diet (ND), and restricted diet (RD) in which rats received 65{\%} of the normal diet. In the OD and ND groups, all structural parameters changed significantly (p<0.05). The degree of alteration in the structural parameters of the ND group was similar to that of the RD group (p<0.05). In simulated compression tests using FE models, the effective modulus of the OD group significantly decreased, depending on measuring time (p<0.05), whereas that of the ND and RD groups significantly increased (p>0.05). The key finding of the present study is that fat mass is morphologically and mechanically inversely correlated with bone mass when the mechanical loading effects of greater body weight on bone mass are applied.",
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Relationship between nutrition factors and osteopenia : Effects of experimental diets on immature bone quality. / Woo, D. G.; Lee, B. Y.; Lim, D.; Kim, H. S.

In: Journal of Biomechanics, Vol. 42, No. 8, 29.05.2009, p. 1102-1107.

Research output: Contribution to journalArticle

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