Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction

Seon Gyu Choi; Myung Ho Jeong; Youngkeun Ahn; Jeong Gwan Cho; Jung Chaee Kang; Shung Chull Chae; Seung Ho Hur; Taek Jong Hong; Young Jo Kim; In Whan Seong; Jei Keon Chae; Jay Young Rhew; In Ho Chae; Myeong Chan Cho; Jang Ho Bae; Seung Woon Rha; Chong Jin Kim; Dong Hoon Choi; Yang Soo Jang; Jung Han Yoon; Wook Sung Chung; Ki Bae Seung; Seung Jung Park; Jong Hyun Kim; Jae Young Rhew; Doo Il Kim; Bon Kwon Koo; Byung Ok Kim; Myoung Yong Lee; Kee Sik Kim; Jin Young Hwang; Seok Kyu Oh; Nae Hee Lee; Kyoung Tae Jeong; Seung Jea Tahk; Keum Soo Park; Kyoo Rok Han; Tae Hoon Ahn; Moo Hyun Kim; Ju Young Yang; Chong Yun Rhim; Hyeon Cheol Gwon; Seong Wook Park; Young Youp Koh; Seung Jae Joo; Soo Joong Kim; Dong Kyu Jin; Jin Man Cho; Sang Wook Kim; Jeong Kyung Kim; Tae Ik Kim; Deug Young Nah; Si Hoon Park; Sang Hyun Lee; Seung Uk Lee; Hang Jae Chung; Jang Hyun Cho; Seung Won Jin

doi:10.4070/kcj.2010.40.11.558

Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction

Seon Gyu Choi, Myung Ho Jeong, Youngkeun Ahn, Jeong Gwan Cho, Jung Chaee Kang, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, Jei Keon Chae, Jay Young Rhew, In Ho Chae, Myeong Chan Cho, Jang Ho Bae, Seung Woon Rha, Chong Jin Kim, Dong Hoon Choi, Yang Soo Jang, Jung Han YoonWook Sung Chung, Ki Bae Seung, Seung Jung Park, Jong Hyun Kim, Jae Young Rhew, Doo Il Kim, Bon Kwon Koo, Byung Ok Kim, Myoung Yong Lee, Kee Sik Kim, Jin Young Hwang, Seok Kyu Oh, Nae Hee Lee, Kyoung Tae Jeong, Seung Jea Tahk, Keum Soo Park, Kyoo Rok Han, Tae Hoon Ahn, Moo Hyun Kim, Ju Young Yang, Chong Yun Rhim, Hyeon Cheol Gwon, Seong Wook Park, Young Youp Koh, Seung Jae Joo, Soo Joong Kim, Dong Kyu Jin, Jin Man Cho, Sang Wook Kim, Jeong Kyung Kim, Tae Ik Kim, Deug Young Nah, Si Hoon Park, Sang Hyun Lee, Seung Uk Lee, Hang Jae Chung, Jang Hyun Cho, Seung Won Jin

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Abstract

Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

Original language	English
Pages (from-to)	558-564
Number of pages	7
Journal	Korean Circulation Journal
Volume	40
Issue number	11
DOIs	https://doi.org/10.4070/kcj.2010.40.11.558
Publication status	Published - 2010 Nov 1

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Internal Medicine
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4070/kcj.2010.40.11.558

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Choi, S. G., Jeong, M. H., Ahn, Y., Cho, J. G., Kang, J. C., Chae, S. C., Hur, S. H., Hong, T. J., Kim, Y. J., Seong, I. W., Chae, J. K., Rhew, J. Y., Chae, I. H., Cho, M. C., Bae, J. H., Rha, S. W., Kim, C. J., Choi, D. H., Jang, Y. S., ... Jin, S. W. (2010). Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction. Korean Circulation Journal, 40(11), 558-564. https://doi.org/10.4070/kcj.2010.40.11.558

@article{9ed95812c3a3471693f3bb0fcb19d339,

title = "Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction",

abstract = "Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.",

author = "Choi, {Seon Gyu} and Jeong, {Myung Ho} and Youngkeun Ahn and Cho, {Jeong Gwan} and Kang, {Jung Chaee} and Chae, {Shung Chull} and Hur, {Seung Ho} and Hong, {Taek Jong} and Kim, {Young Jo} and Seong, {In Whan} and Chae, {Jei Keon} and Rhew, {Jay Young} and Chae, {In Ho} and Cho, {Myeong Chan} and Bae, {Jang Ho} and Rha, {Seung Woon} and Kim, {Chong Jin} and Choi, {Dong Hoon} and Jang, {Yang Soo} and Yoon, {Jung Han} and Chung, {Wook Sung} and Seung, {Ki Bae} and Park, {Seung Jung} and Kim, {Jong Hyun} and Rhew, {Jae Young} and Kim, {Doo Il} and Koo, {Bon Kwon} and Kim, {Byung Ok} and Lee, {Myoung Yong} and Kim, {Kee Sik} and Hwang, {Jin Young} and Oh, {Seok Kyu} and Lee, {Nae Hee} and Jeong, {Kyoung Tae} and Tahk, {Seung Jea} and Park, {Keum Soo} and Han, {Kyoo Rok} and Ahn, {Tae Hoon} and Kim, {Moo Hyun} and Yang, {Ju Young} and Rhim, {Chong Yun} and Gwon, {Hyeon Cheol} and Park, {Seong Wook} and Koh, {Young Youp} and Joo, {Seung Jae} and Kim, {Soo Joong} and Jin, {Dong Kyu} and Cho, {Jin Man} and Kim, {Sang Wook} and Kim, {Jeong Kyung} and Kim, {Tae Ik} and Nah, {Deug Young} and Park, {Si Hoon} and Lee, {Sang Hyun} and Lee, {Seung Uk} and Chung, {Hang Jae} and Cho, {Jang Hyun} and Jin, {Seung Won}",

year = "2010",

month = nov,

day = "1",

doi = "10.4070/kcj.2010.40.11.558",

language = "English",

volume = "40",

pages = "558--564",

journal = "Korean Circulation Journal",

issn = "1738-5520",

publisher = "Korean Society of Circulation",

number = "11",

}

Choi, SG, Jeong, MH, Ahn, Y, Cho, JG, Kang, JC, Chae, SC, Hur, SH, Hong, TJ, Kim, YJ, Seong, IW, Chae, JK, Rhew, JY, Chae, IH, Cho, MC, Bae, JH, Rha, SW, Kim, CJ, Choi, DH , Jang, YS , Yoon, JH, Chung, WS, Seung, KB, Park, SJ, Kim, JH, Rhew, JY, Kim, DI, Koo, BK, Kim, BO, Lee, MY, Kim, KS, Hwang, JY, Oh, SK, Lee, NH, Jeong, KT, Tahk, SJ, Park, KS, Han, KR, Ahn, TH, Kim, MH, Yang, JY, Rhim, CY, Gwon, HC, Park, SW, Koh, YY, Joo, SJ, Kim, SJ, Jin, DK, Cho, JM, Kim, SW, Kim, JK, Kim, TI, Nah, DY, Park, SH, Lee, SH, Lee, SU, Chung, HJ, Cho, JH & Jin, SW 2010, 'Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction', Korean Circulation Journal, vol. 40, no. 11, pp. 558-564. https://doi.org/10.4070/kcj.2010.40.11.558

TY - JOUR

T1 - Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction

AU - Choi, Seon Gyu

AU - Jeong, Myung Ho

AU - Ahn, Youngkeun

AU - Cho, Jeong Gwan

AU - Kang, Jung Chaee

AU - Chae, Shung Chull

AU - Hur, Seung Ho

AU - Hong, Taek Jong

AU - Kim, Young Jo

AU - Seong, In Whan

AU - Chae, Jei Keon

AU - Rhew, Jay Young

AU - Chae, In Ho

AU - Cho, Myeong Chan

AU - Bae, Jang Ho

AU - Rha, Seung Woon

AU - Kim, Chong Jin

AU - Choi, Dong Hoon

AU - Jang, Yang Soo

AU - Yoon, Jung Han

AU - Chung, Wook Sung

AU - Seung, Ki Bae

AU - Park, Seung Jung

AU - Kim, Jong Hyun

AU - Rhew, Jae Young

AU - Kim, Doo Il

AU - Koo, Bon Kwon

AU - Kim, Byung Ok

AU - Lee, Myoung Yong

AU - Kim, Kee Sik

AU - Hwang, Jin Young

AU - Oh, Seok Kyu

AU - Lee, Nae Hee

AU - Jeong, Kyoung Tae

AU - Tahk, Seung Jea

AU - Park, Keum Soo

AU - Han, Kyoo Rok

AU - Ahn, Tae Hoon

AU - Kim, Moo Hyun

AU - Yang, Ju Young

AU - Rhim, Chong Yun

AU - Gwon, Hyeon Cheol

AU - Park, Seong Wook

AU - Koh, Young Youp

AU - Joo, Seung Jae

AU - Kim, Soo Joong

AU - Jin, Dong Kyu

AU - Cho, Jin Man

AU - Kim, Sang Wook

AU - Kim, Jeong Kyung

AU - Kim, Tae Ik

AU - Nah, Deug Young

AU - Park, Si Hoon

AU - Lee, Sang Hyun

AU - Lee, Seung Uk

AU - Chung, Hang Jae

AU - Cho, Jang Hyun

AU - Jin, Seung Won

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

AB - Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.

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UR - http://www.scopus.com/inward/citedby.url?scp=78650882655&partnerID=8YFLogxK

U2 - 10.4070/kcj.2010.40.11.558

DO - 10.4070/kcj.2010.40.11.558

M3 - Article

C2 - 21217932

AN - SCOPUS:78650882655

SN - 1738-5520

VL - 40

SP - 558

EP - 564

JO - Korean Circulation Journal

JF - Korean Circulation Journal

IS - 11

ER -

Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction

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