Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population

Korea national health and nutrition examination survey, 2007–2010

Sung Woo Moon, Song Yee Kim, Ji Ye Jung, youngae kang, Moo Suk Park, Young Sam Kim, Joon Chang, Jun Soo Ro, Yong Ho Lee, Sang Hoon Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Previous studies have shown that progressive forms of non-alcoholic fatty liver disease (NAFLD) occur frequently in patients with obstructive lung disease (OLD). However, few studies have written about this relationship. This study aimed to investigate the relationship between OLD and NAFLD. Subjects and methods: The Korea National Health and Nutrition Examination Survey is a national population-based, cross-sectional surveillance program that was initiated to assess the health and nutritional status of the Korean population. From 2007 to 2010, 11,738 subjects were enrolled. The subjects were defined as having NAFLD when they had scores higher than-0.640 in a NAFLD liver fat score prediction model, which was a previously validated prediction score. Individuals with forced expiratory volume in one second/forced vital capacity <0.7 were considered to have OLD. The subjects were divided into non-OLD and OLD groups and non-NAFLD and NAFLD groups. All analyses were performed using sample weighting using the complex samples plan. Results: The prevalences of NAFLD and OLD were 30.2% and 8.9%, respectively. Although not statistically significant, subjects in the NAFLD group involved a higher tendency of having OLD than did those in the non-NAFLD group (8.5% vs 10.0%, respectively, P=0.060). Subjects with OLD showed a higher tendency to have NAFLD than non-OLD subjects (30.0% vs 33.7%, respectively, P=0.060). NAFLD subjects were at higher odds of OLD (odds ratio=1.334; 95% confidence interval=1.108–1.607, P=0.002) than non-NAFLD subjects, after adjusting for age, sex, and smoking history. OLD subjects were at higher odds of NAFLD (odds ratio=1.556; 95% confidence interval=1.288–1.879, P<0.001) than non-OLD subjects, after adjusting for age, sex, and smoking history. Conclusion: This study showed that NAFLD is related to OLD. Clinicians should be aware of possible liver comorbidities in OLD patients and that extrahepatic disease in NAFLD patients may vary more than previously thought.

Original languageEnglish
Pages (from-to)2603-2611
Number of pages9
JournalInternational Journal of COPD
Volume13
DOIs
Publication statusPublished - 2018 Jan 1

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Obstructive Lung Diseases
Nutrition Surveys
Korea
Population
Fatty Liver
Lung Diseases
Non-alcoholic Fatty Liver Disease
Liver Diseases
Smoking
History
Odds Ratio
Confidence Intervals
Liver
Vital Capacity
Forced Expiratory Volume
Nutritional Status
Health Status
Comorbidity

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Moon, Sung Woo ; Kim, Song Yee ; Jung, Ji Ye ; kang, youngae ; Park, Moo Suk ; Kim, Young Sam ; Chang, Joon ; Ro, Jun Soo ; Lee, Yong Ho ; Lee, Sang Hoon. / Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population : Korea national health and nutrition examination survey, 2007–2010. In: International Journal of COPD. 2018 ; Vol. 13. pp. 2603-2611.
@article{a0e68fa434ed4d6c866905b26898c434,
title = "Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea national health and nutrition examination survey, 2007–2010",
abstract = "Purpose: Previous studies have shown that progressive forms of non-alcoholic fatty liver disease (NAFLD) occur frequently in patients with obstructive lung disease (OLD). However, few studies have written about this relationship. This study aimed to investigate the relationship between OLD and NAFLD. Subjects and methods: The Korea National Health and Nutrition Examination Survey is a national population-based, cross-sectional surveillance program that was initiated to assess the health and nutritional status of the Korean population. From 2007 to 2010, 11,738 subjects were enrolled. The subjects were defined as having NAFLD when they had scores higher than-0.640 in a NAFLD liver fat score prediction model, which was a previously validated prediction score. Individuals with forced expiratory volume in one second/forced vital capacity <0.7 were considered to have OLD. The subjects were divided into non-OLD and OLD groups and non-NAFLD and NAFLD groups. All analyses were performed using sample weighting using the complex samples plan. Results: The prevalences of NAFLD and OLD were 30.2{\%} and 8.9{\%}, respectively. Although not statistically significant, subjects in the NAFLD group involved a higher tendency of having OLD than did those in the non-NAFLD group (8.5{\%} vs 10.0{\%}, respectively, P=0.060). Subjects with OLD showed a higher tendency to have NAFLD than non-OLD subjects (30.0{\%} vs 33.7{\%}, respectively, P=0.060). NAFLD subjects were at higher odds of OLD (odds ratio=1.334; 95{\%} confidence interval=1.108–1.607, P=0.002) than non-NAFLD subjects, after adjusting for age, sex, and smoking history. OLD subjects were at higher odds of NAFLD (odds ratio=1.556; 95{\%} confidence interval=1.288–1.879, P<0.001) than non-OLD subjects, after adjusting for age, sex, and smoking history. Conclusion: This study showed that NAFLD is related to OLD. Clinicians should be aware of possible liver comorbidities in OLD patients and that extrahepatic disease in NAFLD patients may vary more than previously thought.",
author = "Moon, {Sung Woo} and Kim, {Song Yee} and Jung, {Ji Ye} and youngae kang and Park, {Moo Suk} and Kim, {Young Sam} and Joon Chang and Ro, {Jun Soo} and Lee, {Yong Ho} and Lee, {Sang Hoon}",
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journal = "International Journal of COPD",
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Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population : Korea national health and nutrition examination survey, 2007–2010. / Moon, Sung Woo; Kim, Song Yee; Jung, Ji Ye; kang, youngae; Park, Moo Suk; Kim, Young Sam; Chang, Joon; Ro, Jun Soo; Lee, Yong Ho; Lee, Sang Hoon.

In: International Journal of COPD, Vol. 13, 01.01.2018, p. 2603-2611.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population

T2 - Korea national health and nutrition examination survey, 2007–2010

AU - Moon, Sung Woo

AU - Kim, Song Yee

AU - Jung, Ji Ye

AU - kang, youngae

AU - Park, Moo Suk

AU - Kim, Young Sam

AU - Chang, Joon

AU - Ro, Jun Soo

AU - Lee, Yong Ho

AU - Lee, Sang Hoon

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: Previous studies have shown that progressive forms of non-alcoholic fatty liver disease (NAFLD) occur frequently in patients with obstructive lung disease (OLD). However, few studies have written about this relationship. This study aimed to investigate the relationship between OLD and NAFLD. Subjects and methods: The Korea National Health and Nutrition Examination Survey is a national population-based, cross-sectional surveillance program that was initiated to assess the health and nutritional status of the Korean population. From 2007 to 2010, 11,738 subjects were enrolled. The subjects were defined as having NAFLD when they had scores higher than-0.640 in a NAFLD liver fat score prediction model, which was a previously validated prediction score. Individuals with forced expiratory volume in one second/forced vital capacity <0.7 were considered to have OLD. The subjects were divided into non-OLD and OLD groups and non-NAFLD and NAFLD groups. All analyses were performed using sample weighting using the complex samples plan. Results: The prevalences of NAFLD and OLD were 30.2% and 8.9%, respectively. Although not statistically significant, subjects in the NAFLD group involved a higher tendency of having OLD than did those in the non-NAFLD group (8.5% vs 10.0%, respectively, P=0.060). Subjects with OLD showed a higher tendency to have NAFLD than non-OLD subjects (30.0% vs 33.7%, respectively, P=0.060). NAFLD subjects were at higher odds of OLD (odds ratio=1.334; 95% confidence interval=1.108–1.607, P=0.002) than non-NAFLD subjects, after adjusting for age, sex, and smoking history. OLD subjects were at higher odds of NAFLD (odds ratio=1.556; 95% confidence interval=1.288–1.879, P<0.001) than non-OLD subjects, after adjusting for age, sex, and smoking history. Conclusion: This study showed that NAFLD is related to OLD. Clinicians should be aware of possible liver comorbidities in OLD patients and that extrahepatic disease in NAFLD patients may vary more than previously thought.

AB - Purpose: Previous studies have shown that progressive forms of non-alcoholic fatty liver disease (NAFLD) occur frequently in patients with obstructive lung disease (OLD). However, few studies have written about this relationship. This study aimed to investigate the relationship between OLD and NAFLD. Subjects and methods: The Korea National Health and Nutrition Examination Survey is a national population-based, cross-sectional surveillance program that was initiated to assess the health and nutritional status of the Korean population. From 2007 to 2010, 11,738 subjects were enrolled. The subjects were defined as having NAFLD when they had scores higher than-0.640 in a NAFLD liver fat score prediction model, which was a previously validated prediction score. Individuals with forced expiratory volume in one second/forced vital capacity <0.7 were considered to have OLD. The subjects were divided into non-OLD and OLD groups and non-NAFLD and NAFLD groups. All analyses were performed using sample weighting using the complex samples plan. Results: The prevalences of NAFLD and OLD were 30.2% and 8.9%, respectively. Although not statistically significant, subjects in the NAFLD group involved a higher tendency of having OLD than did those in the non-NAFLD group (8.5% vs 10.0%, respectively, P=0.060). Subjects with OLD showed a higher tendency to have NAFLD than non-OLD subjects (30.0% vs 33.7%, respectively, P=0.060). NAFLD subjects were at higher odds of OLD (odds ratio=1.334; 95% confidence interval=1.108–1.607, P=0.002) than non-NAFLD subjects, after adjusting for age, sex, and smoking history. OLD subjects were at higher odds of NAFLD (odds ratio=1.556; 95% confidence interval=1.288–1.879, P<0.001) than non-OLD subjects, after adjusting for age, sex, and smoking history. Conclusion: This study showed that NAFLD is related to OLD. Clinicians should be aware of possible liver comorbidities in OLD patients and that extrahepatic disease in NAFLD patients may vary more than previously thought.

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U2 - 10.2147/COPD.S166902

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JO - International Journal of COPD

JF - International Journal of COPD

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