Relationship between serum prostate-specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study

Jin Seon Cho, Chun Il Kim, Do Hwan Seong, Hong Sup Kim, Young Sik Kim, Se Joong Kim, In Rae Cho, Sang Hyeon Cheon, Dong Hyeon Lee, Won Jae Yang, Young Deuk Choi, Sung Joon Hong, Young Su Ju, Yun Seob Song, Sun Il Kim, Byung Ha Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Prostate volume (PV) is a key predictor of both the progression and response to medical therapy in patients with benign prostatic hyperplasia (BPH). Prostate-specific antigen (PSA) has been studied as a proxy marker for the estimation of the total PV in a predominantly Caucasian patient population. If the PV of Korean men is smaller than that of Caucasian men, the PSA-PV of Korean men may be different from those of the other races. The relationship between the PSA and PV was evaluated in Korean men. Materials and methods: Patients with lower urinary tract symptoms and BPH, aged between 50 and 79 years, between 1999 and 2004, were enrolled in this multicentered study. IPSS, PSA, uroflowmetry and TRUS measurements were performed on all patients. Men with a PSA greater than 10ng/ml were excluded to reduce the likelihood of including occult prostate cancer cases. Those with suspicious findings on digital rectal examination and serum PSA were biopsied to rule out prostate cancer. Results: The analysis included 5,716 patients, with a mean age 64.3 years, and mean baseline PV and PSA of 36.9ml and 2.4ng/ml, respectively. The PV and serum PSA have an age-dependent log-linear relationship. Older men tend to have a steeper rate of increase in their PV with increasing serum PSA. Receiver operating characteristic (ROC) curves were constructed to evaluate the ability of the serum PSA to predict the threshold of the PV in men with BPH. The ROC curve analysis revealed that the PSA had good predictive value for various PV cutoff points (30, 40 and 50ml). Conclusions: The PSA-PV relationship in Korean men was similar to that in Caucasians. However, Korean men have a lower PSA and smaller PV than Caucasians. Approximate age-specific criteria for detecting Korean men with PV exceeding 40ml are: PSA >1.3ng/ml, >1.7ng/ml and >2.0 ng/ml for men with BPH in their 50s, 60s and 70s, respectively.

Original languageEnglish
Pages (from-to)792-798
Number of pages7
JournalKorean Journal of Urology
Volume46
Issue number8
Publication statusPublished - 2005 Aug 1

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Prostatic Hyperplasia
Prostate-Specific Antigen
Multicenter Studies
Prostate
Serum
ROC Curve
Prostatic Neoplasms
Digital Rectal Examination
Lower Urinary Tract Symptoms
Proxy

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Cho, Jin Seon ; Kim, Chun Il ; Seong, Do Hwan ; Kim, Hong Sup ; Kim, Young Sik ; Kim, Se Joong ; Cho, In Rae ; Cheon, Sang Hyeon ; Lee, Dong Hyeon ; Yang, Won Jae ; Choi, Young Deuk ; Hong, Sung Joon ; Ju, Young Su ; Song, Yun Seob ; Kim, Sun Il ; Chung, Byung Ha. / Relationship between serum prostate-specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study. In: Korean Journal of Urology. 2005 ; Vol. 46, No. 8. pp. 792-798.
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title = "Relationship between serum prostate-specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study",
abstract = "Purpose: Prostate volume (PV) is a key predictor of both the progression and response to medical therapy in patients with benign prostatic hyperplasia (BPH). Prostate-specific antigen (PSA) has been studied as a proxy marker for the estimation of the total PV in a predominantly Caucasian patient population. If the PV of Korean men is smaller than that of Caucasian men, the PSA-PV of Korean men may be different from those of the other races. The relationship between the PSA and PV was evaluated in Korean men. Materials and methods: Patients with lower urinary tract symptoms and BPH, aged between 50 and 79 years, between 1999 and 2004, were enrolled in this multicentered study. IPSS, PSA, uroflowmetry and TRUS measurements were performed on all patients. Men with a PSA greater than 10ng/ml were excluded to reduce the likelihood of including occult prostate cancer cases. Those with suspicious findings on digital rectal examination and serum PSA were biopsied to rule out prostate cancer. Results: The analysis included 5,716 patients, with a mean age 64.3 years, and mean baseline PV and PSA of 36.9ml and 2.4ng/ml, respectively. The PV and serum PSA have an age-dependent log-linear relationship. Older men tend to have a steeper rate of increase in their PV with increasing serum PSA. Receiver operating characteristic (ROC) curves were constructed to evaluate the ability of the serum PSA to predict the threshold of the PV in men with BPH. The ROC curve analysis revealed that the PSA had good predictive value for various PV cutoff points (30, 40 and 50ml). Conclusions: The PSA-PV relationship in Korean men was similar to that in Caucasians. However, Korean men have a lower PSA and smaller PV than Caucasians. Approximate age-specific criteria for detecting Korean men with PV exceeding 40ml are: PSA >1.3ng/ml, >1.7ng/ml and >2.0 ng/ml for men with BPH in their 50s, 60s and 70s, respectively.",
author = "Cho, {Jin Seon} and Kim, {Chun Il} and Seong, {Do Hwan} and Kim, {Hong Sup} and Kim, {Young Sik} and Kim, {Se Joong} and Cho, {In Rae} and Cheon, {Sang Hyeon} and Lee, {Dong Hyeon} and Yang, {Won Jae} and Choi, {Young Deuk} and Hong, {Sung Joon} and Ju, {Young Su} and Song, {Yun Seob} and Kim, {Sun Il} and Chung, {Byung Ha}",
year = "2005",
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Cho, JS, Kim, CI, Seong, DH, Kim, HS, Kim, YS, Kim, SJ, Cho, IR, Cheon, SH, Lee, DH, Yang, WJ, Choi, YD, Hong, SJ, Ju, YS, Song, YS, Kim, SI & Chung, BH 2005, 'Relationship between serum prostate-specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study', Korean Journal of Urology, vol. 46, no. 8, pp. 792-798.

Relationship between serum prostate-specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study. / Cho, Jin Seon; Kim, Chun Il; Seong, Do Hwan; Kim, Hong Sup; Kim, Young Sik; Kim, Se Joong; Cho, In Rae; Cheon, Sang Hyeon; Lee, Dong Hyeon; Yang, Won Jae; Choi, Young Deuk; Hong, Sung Joon; Ju, Young Su; Song, Yun Seob; Kim, Sun Il; Chung, Byung Ha.

In: Korean Journal of Urology, Vol. 46, No. 8, 01.08.2005, p. 792-798.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between serum prostate-specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study

AU - Cho, Jin Seon

AU - Kim, Chun Il

AU - Seong, Do Hwan

AU - Kim, Hong Sup

AU - Kim, Young Sik

AU - Kim, Se Joong

AU - Cho, In Rae

AU - Cheon, Sang Hyeon

AU - Lee, Dong Hyeon

AU - Yang, Won Jae

AU - Choi, Young Deuk

AU - Hong, Sung Joon

AU - Ju, Young Su

AU - Song, Yun Seob

AU - Kim, Sun Il

AU - Chung, Byung Ha

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Purpose: Prostate volume (PV) is a key predictor of both the progression and response to medical therapy in patients with benign prostatic hyperplasia (BPH). Prostate-specific antigen (PSA) has been studied as a proxy marker for the estimation of the total PV in a predominantly Caucasian patient population. If the PV of Korean men is smaller than that of Caucasian men, the PSA-PV of Korean men may be different from those of the other races. The relationship between the PSA and PV was evaluated in Korean men. Materials and methods: Patients with lower urinary tract symptoms and BPH, aged between 50 and 79 years, between 1999 and 2004, were enrolled in this multicentered study. IPSS, PSA, uroflowmetry and TRUS measurements were performed on all patients. Men with a PSA greater than 10ng/ml were excluded to reduce the likelihood of including occult prostate cancer cases. Those with suspicious findings on digital rectal examination and serum PSA were biopsied to rule out prostate cancer. Results: The analysis included 5,716 patients, with a mean age 64.3 years, and mean baseline PV and PSA of 36.9ml and 2.4ng/ml, respectively. The PV and serum PSA have an age-dependent log-linear relationship. Older men tend to have a steeper rate of increase in their PV with increasing serum PSA. Receiver operating characteristic (ROC) curves were constructed to evaluate the ability of the serum PSA to predict the threshold of the PV in men with BPH. The ROC curve analysis revealed that the PSA had good predictive value for various PV cutoff points (30, 40 and 50ml). Conclusions: The PSA-PV relationship in Korean men was similar to that in Caucasians. However, Korean men have a lower PSA and smaller PV than Caucasians. Approximate age-specific criteria for detecting Korean men with PV exceeding 40ml are: PSA >1.3ng/ml, >1.7ng/ml and >2.0 ng/ml for men with BPH in their 50s, 60s and 70s, respectively.

AB - Purpose: Prostate volume (PV) is a key predictor of both the progression and response to medical therapy in patients with benign prostatic hyperplasia (BPH). Prostate-specific antigen (PSA) has been studied as a proxy marker for the estimation of the total PV in a predominantly Caucasian patient population. If the PV of Korean men is smaller than that of Caucasian men, the PSA-PV of Korean men may be different from those of the other races. The relationship between the PSA and PV was evaluated in Korean men. Materials and methods: Patients with lower urinary tract symptoms and BPH, aged between 50 and 79 years, between 1999 and 2004, were enrolled in this multicentered study. IPSS, PSA, uroflowmetry and TRUS measurements were performed on all patients. Men with a PSA greater than 10ng/ml were excluded to reduce the likelihood of including occult prostate cancer cases. Those with suspicious findings on digital rectal examination and serum PSA were biopsied to rule out prostate cancer. Results: The analysis included 5,716 patients, with a mean age 64.3 years, and mean baseline PV and PSA of 36.9ml and 2.4ng/ml, respectively. The PV and serum PSA have an age-dependent log-linear relationship. Older men tend to have a steeper rate of increase in their PV with increasing serum PSA. Receiver operating characteristic (ROC) curves were constructed to evaluate the ability of the serum PSA to predict the threshold of the PV in men with BPH. The ROC curve analysis revealed that the PSA had good predictive value for various PV cutoff points (30, 40 and 50ml). Conclusions: The PSA-PV relationship in Korean men was similar to that in Caucasians. However, Korean men have a lower PSA and smaller PV than Caucasians. Approximate age-specific criteria for detecting Korean men with PV exceeding 40ml are: PSA >1.3ng/ml, >1.7ng/ml and >2.0 ng/ml for men with BPH in their 50s, 60s and 70s, respectively.

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JO - Korean Journal of Urology

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