Relationship between tetrahydrobiopterin and portal hypertension in patients with chronic liver disease

Won Ki Hong, Kwang Yong Shim, Soonkoo Baik, Moonyoung Kim, Meeyon Cho, Yoon Ok Jang, Young Shik Park, Jin Han, Gaeun Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Sang Ok Kwon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Tetrahydrobiopterin (BH4) is an essential cofactor in NO synthesis by endothelial nitric oxide synthase (eNOS) enzymes. It has been previously suggested that reduced intrahepatic BH4 results in a decrease in intrahepatic NO and contributes to increased hepatic vascular resistance and portal pressure in animal models of cirrhosis. The main aim of the present study was to evaluate the relationship between BH4 and portal hypertension (PHT). One hundred ninety-three consecutive patients with chronic liver disease were included in the study. Liver biopsy, measurement of BH4 and hepatic venous pressure gradient (HVPG) were performed. Hepatic fibrosis was classified using the Laennec fibrosis scoring system. BH4 levels were determined in homogenized liver tissues of patients using a high performance liquid chromatography (HPLC) system. Statistical analysis was performed to evaluate the relationship between BH4 and HVPG, grade of hepatic fibrosis, clinical stage of cirrhosis, Child-Pugh class. A positive relationship between HVPG and hepatic fibrosis grade, clinical stage of cirrhosis and Child-Pugh class was observed. However, the BH4 level showed no significant correlation with HVPG or clinical features of cirrhosis. BH4 concentration in liver tissue has little relation to the severity of portal hypertension in patients with chronic liver disease.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalJournal of Korean medical science
Volume29
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Portal Hypertension
Liver Diseases
Chronic Disease
Fibrosis
Liver
Venous Pressure
sapropterin
Portal Pressure
Nitric Oxide Synthase Type III
Vascular Resistance
Animal Models
High Pressure Liquid Chromatography
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hong, Won Ki ; Shim, Kwang Yong ; Baik, Soonkoo ; Kim, Moonyoung ; Cho, Meeyon ; Jang, Yoon Ok ; Park, Young Shik ; Han, Jin ; Kim, Gaeun ; Cho, Youn Zoo ; Hwang, Hye Won ; Lee, Jin Hyung ; Chae, Myeong Hun ; Kwon, Sang Ok. / Relationship between tetrahydrobiopterin and portal hypertension in patients with chronic liver disease. In: Journal of Korean medical science. 2014 ; Vol. 29, No. 3. pp. 392-399.
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abstract = "Tetrahydrobiopterin (BH4) is an essential cofactor in NO synthesis by endothelial nitric oxide synthase (eNOS) enzymes. It has been previously suggested that reduced intrahepatic BH4 results in a decrease in intrahepatic NO and contributes to increased hepatic vascular resistance and portal pressure in animal models of cirrhosis. The main aim of the present study was to evaluate the relationship between BH4 and portal hypertension (PHT). One hundred ninety-three consecutive patients with chronic liver disease were included in the study. Liver biopsy, measurement of BH4 and hepatic venous pressure gradient (HVPG) were performed. Hepatic fibrosis was classified using the Laennec fibrosis scoring system. BH4 levels were determined in homogenized liver tissues of patients using a high performance liquid chromatography (HPLC) system. Statistical analysis was performed to evaluate the relationship between BH4 and HVPG, grade of hepatic fibrosis, clinical stage of cirrhosis, Child-Pugh class. A positive relationship between HVPG and hepatic fibrosis grade, clinical stage of cirrhosis and Child-Pugh class was observed. However, the BH4 level showed no significant correlation with HVPG or clinical features of cirrhosis. BH4 concentration in liver tissue has little relation to the severity of portal hypertension in patients with chronic liver disease.",
author = "Hong, {Won Ki} and Shim, {Kwang Yong} and Soonkoo Baik and Moonyoung Kim and Meeyon Cho and Jang, {Yoon Ok} and Park, {Young Shik} and Jin Han and Gaeun Kim and Cho, {Youn Zoo} and Hwang, {Hye Won} and Lee, {Jin Hyung} and Chae, {Myeong Hun} and Kwon, {Sang Ok}",
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Hong, WK, Shim, KY, Baik, S, Kim, M, Cho, M, Jang, YO, Park, YS, Han, J, Kim, G, Cho, YZ, Hwang, HW, Lee, JH, Chae, MH & Kwon, SO 2014, 'Relationship between tetrahydrobiopterin and portal hypertension in patients with chronic liver disease', Journal of Korean medical science, vol. 29, no. 3, pp. 392-399. https://doi.org/10.3346/jkms.2014.29.3.392

Relationship between tetrahydrobiopterin and portal hypertension in patients with chronic liver disease. / Hong, Won Ki; Shim, Kwang Yong; Baik, Soonkoo; Kim, Moonyoung; Cho, Meeyon; Jang, Yoon Ok; Park, Young Shik; Han, Jin; Kim, Gaeun; Cho, Youn Zoo; Hwang, Hye Won; Lee, Jin Hyung; Chae, Myeong Hun; Kwon, Sang Ok.

In: Journal of Korean medical science, Vol. 29, No. 3, 01.01.2014, p. 392-399.

Research output: Contribution to journalArticle

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T1 - Relationship between tetrahydrobiopterin and portal hypertension in patients with chronic liver disease

AU - Hong, Won Ki

AU - Shim, Kwang Yong

AU - Baik, Soonkoo

AU - Kim, Moonyoung

AU - Cho, Meeyon

AU - Jang, Yoon Ok

AU - Park, Young Shik

AU - Han, Jin

AU - Kim, Gaeun

AU - Cho, Youn Zoo

AU - Hwang, Hye Won

AU - Lee, Jin Hyung

AU - Chae, Myeong Hun

AU - Kwon, Sang Ok

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Tetrahydrobiopterin (BH4) is an essential cofactor in NO synthesis by endothelial nitric oxide synthase (eNOS) enzymes. It has been previously suggested that reduced intrahepatic BH4 results in a decrease in intrahepatic NO and contributes to increased hepatic vascular resistance and portal pressure in animal models of cirrhosis. The main aim of the present study was to evaluate the relationship between BH4 and portal hypertension (PHT). One hundred ninety-three consecutive patients with chronic liver disease were included in the study. Liver biopsy, measurement of BH4 and hepatic venous pressure gradient (HVPG) were performed. Hepatic fibrosis was classified using the Laennec fibrosis scoring system. BH4 levels were determined in homogenized liver tissues of patients using a high performance liquid chromatography (HPLC) system. Statistical analysis was performed to evaluate the relationship between BH4 and HVPG, grade of hepatic fibrosis, clinical stage of cirrhosis, Child-Pugh class. A positive relationship between HVPG and hepatic fibrosis grade, clinical stage of cirrhosis and Child-Pugh class was observed. However, the BH4 level showed no significant correlation with HVPG or clinical features of cirrhosis. BH4 concentration in liver tissue has little relation to the severity of portal hypertension in patients with chronic liver disease.

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