Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis

a multicenter retrospective study in Korea.

Jin Nyoung Kim, Kyoung Min Sohn, Moonyoung Kim, Ki Tae Suk, Soung Won Jeong, Ho Eun Jung, Sae Hwan Lee, Sang Gyune Kim, Jae Young Jang, Young Seok Kim, Soonkoo Baik, Hong Soo Kim, Dong Joon Kim, Boo Sung Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined. Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices. The HVPG for all patients was 16.46±7.05 mmHg (mean±SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%. The HVPG was higher in patients with first variceal hemorrhage than in those without it.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalUnknown Journal
Volume18
Issue number4
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Venous Pressure
Korea
Multicenter Studies
Fibrosis
Retrospective Studies
Hemorrhage
Liver
Varicose Veins
Digestive System Endoscopy
End Stage Liver Disease
Portal Hypertension
Gradient
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Molecular Biology

Cite this

Kim, Jin Nyoung ; Sohn, Kyoung Min ; Kim, Moonyoung ; Suk, Ki Tae ; Jeong, Soung Won ; Jung, Ho Eun ; Lee, Sae Hwan ; Kim, Sang Gyune ; Jang, Jae Young ; Kim, Young Seok ; Baik, Soonkoo ; Kim, Hong Soo ; Kim, Dong Joon ; Kim, Boo Sung. / Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis : a multicenter retrospective study in Korea. In: Unknown Journal. 2012 ; Vol. 18, No. 4. pp. 391-396.
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Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis : a multicenter retrospective study in Korea. / Kim, Jin Nyoung; Sohn, Kyoung Min; Kim, Moonyoung; Suk, Ki Tae; Jeong, Soung Won; Jung, Ho Eun; Lee, Sae Hwan; Kim, Sang Gyune; Jang, Jae Young; Kim, Young Seok; Baik, Soonkoo; Kim, Hong Soo; Kim, Dong Joon; Kim, Boo Sung.

In: Unknown Journal, Vol. 18, No. 4, 01.01.2012, p. 391-396.

Research output: Contribution to journalArticle

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AU - Kim, Dong Joon

AU - Kim, Boo Sung

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