Abstract
Background: Higher levels of white blood cell (WBC) count are known to be associated with metabolic syndrome and insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. Aims: The present study aimed to determine the relation between WBC count and the presence of NAFLD based on abdominal sonographic findings. Methods: A cross-sectional study with 3681 healthy subjects (2066 men, 1615 women) undergoing medical check-up was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated using multivariate logistic regression analyses across WBC quartiles. Results: A graded independent relationship between higher levels of WBC count and the prevalence risk of NAFLD was observed. After adjusting for age, smoking status, regular exercise, body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol, the ORs (95% CIs) for NAFLD according to WBC quartiles were 1.00, 1.48 (1.10-1.98), 1.59 (1.18-2.14), and 1.84 (1.35-2.51) for men and 1.00, 1.15 (0.67-1.96), 1.88 (1.13-3.11), and 2.74 (1.68-4.46) for women. Conclusions: WBC count was found to be independently associated with the presence of NAFLD regardless of classical cardiovascular risk factors and other components of metabolic syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 888-894 |
| Number of pages | 7 |
| Journal | Digestive and Liver Disease |
| Volume | 42 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2010 Dec 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
Cite this
}
Relationship between white blood cell count and nonalcoholic fatty liver disease. / Lee, Yongjae; Lee, Hye Ree; Shim, Jae Yong; Moon, Byung Soo; Lee, Jung Hyun; Kim, Jong Koo.
In: Digestive and Liver Disease, Vol. 42, No. 12, 01.12.2010, p. 888-894.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship between white blood cell count and nonalcoholic fatty liver disease
AU - Lee, Yongjae
AU - Lee, Hye Ree
AU - Shim, Jae Yong
AU - Moon, Byung Soo
AU - Lee, Jung Hyun
AU - Kim, Jong Koo
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Background: Higher levels of white blood cell (WBC) count are known to be associated with metabolic syndrome and insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. Aims: The present study aimed to determine the relation between WBC count and the presence of NAFLD based on abdominal sonographic findings. Methods: A cross-sectional study with 3681 healthy subjects (2066 men, 1615 women) undergoing medical check-up was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated using multivariate logistic regression analyses across WBC quartiles. Results: A graded independent relationship between higher levels of WBC count and the prevalence risk of NAFLD was observed. After adjusting for age, smoking status, regular exercise, body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol, the ORs (95% CIs) for NAFLD according to WBC quartiles were 1.00, 1.48 (1.10-1.98), 1.59 (1.18-2.14), and 1.84 (1.35-2.51) for men and 1.00, 1.15 (0.67-1.96), 1.88 (1.13-3.11), and 2.74 (1.68-4.46) for women. Conclusions: WBC count was found to be independently associated with the presence of NAFLD regardless of classical cardiovascular risk factors and other components of metabolic syndrome.
AB - Background: Higher levels of white blood cell (WBC) count are known to be associated with metabolic syndrome and insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. Aims: The present study aimed to determine the relation between WBC count and the presence of NAFLD based on abdominal sonographic findings. Methods: A cross-sectional study with 3681 healthy subjects (2066 men, 1615 women) undergoing medical check-up was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated using multivariate logistic regression analyses across WBC quartiles. Results: A graded independent relationship between higher levels of WBC count and the prevalence risk of NAFLD was observed. After adjusting for age, smoking status, regular exercise, body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol, the ORs (95% CIs) for NAFLD according to WBC quartiles were 1.00, 1.48 (1.10-1.98), 1.59 (1.18-2.14), and 1.84 (1.35-2.51) for men and 1.00, 1.15 (0.67-1.96), 1.88 (1.13-3.11), and 2.74 (1.68-4.46) for women. Conclusions: WBC count was found to be independently associated with the presence of NAFLD regardless of classical cardiovascular risk factors and other components of metabolic syndrome.
UR - http://www.scopus.com/inward/record.url?scp=78650276180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650276180&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2010.04.005
DO - 10.1016/j.dld.2010.04.005
M3 - Article
C2 - 20472517
AN - SCOPUS:78650276180
VL - 42
SP - 888
EP - 894
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 12
ER -