Relationship between white blood cell count and nonalcoholic fatty liver disease

Yongjae Lee, Hye Ree Lee, Jae Yong Shim, Byung Soo Moon, Jung Hyun Lee, Jong Koo Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Higher levels of white blood cell (WBC) count are known to be associated with metabolic syndrome and insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. Aims: The present study aimed to determine the relation between WBC count and the presence of NAFLD based on abdominal sonographic findings. Methods: A cross-sectional study with 3681 healthy subjects (2066 men, 1615 women) undergoing medical check-up was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated using multivariate logistic regression analyses across WBC quartiles. Results: A graded independent relationship between higher levels of WBC count and the prevalence risk of NAFLD was observed. After adjusting for age, smoking status, regular exercise, body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol, the ORs (95% CIs) for NAFLD according to WBC quartiles were 1.00, 1.48 (1.10-1.98), 1.59 (1.18-2.14), and 1.84 (1.35-2.51) for men and 1.00, 1.15 (0.67-1.96), 1.88 (1.13-3.11), and 2.74 (1.68-4.46) for women. Conclusions: WBC count was found to be independently associated with the presence of NAFLD regardless of classical cardiovascular risk factors and other components of metabolic syndrome.

Original languageEnglish
Pages (from-to)888-894
Number of pages7
JournalDigestive and Liver Disease
Volume42
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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Leukocyte Count
Insulin Resistance
Leukocytes
Odds Ratio
Confidence Intervals
HDL Cholesterol
Non-alcoholic Fatty Liver Disease
Fasting
Healthy Volunteers
Triglycerides
Body Mass Index
Cross-Sectional Studies
Logistic Models
Smoking
Regression Analysis
Exercise
Blood Pressure
Glucose
Liver

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Lee, Yongjae ; Lee, Hye Ree ; Shim, Jae Yong ; Moon, Byung Soo ; Lee, Jung Hyun ; Kim, Jong Koo. / Relationship between white blood cell count and nonalcoholic fatty liver disease. In: Digestive and Liver Disease. 2010 ; Vol. 42, No. 12. pp. 888-894.
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Relationship between white blood cell count and nonalcoholic fatty liver disease. / Lee, Yongjae; Lee, Hye Ree; Shim, Jae Yong; Moon, Byung Soo; Lee, Jung Hyun; Kim, Jong Koo.

In: Digestive and Liver Disease, Vol. 42, No. 12, 01.12.2010, p. 888-894.

Research output: Contribution to journalArticle

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N2 - Background: Higher levels of white blood cell (WBC) count are known to be associated with metabolic syndrome and insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. Aims: The present study aimed to determine the relation between WBC count and the presence of NAFLD based on abdominal sonographic findings. Methods: A cross-sectional study with 3681 healthy subjects (2066 men, 1615 women) undergoing medical check-up was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated using multivariate logistic regression analyses across WBC quartiles. Results: A graded independent relationship between higher levels of WBC count and the prevalence risk of NAFLD was observed. After adjusting for age, smoking status, regular exercise, body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol, the ORs (95% CIs) for NAFLD according to WBC quartiles were 1.00, 1.48 (1.10-1.98), 1.59 (1.18-2.14), and 1.84 (1.35-2.51) for men and 1.00, 1.15 (0.67-1.96), 1.88 (1.13-3.11), and 2.74 (1.68-4.46) for women. Conclusions: WBC count was found to be independently associated with the presence of NAFLD regardless of classical cardiovascular risk factors and other components of metabolic syndrome.

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