Relationship of body composition and C-reactive protein with pulmonary function

Dong Hyuk Jung, Jae Yong Shim, Hong Yup Ahn, Hye Ree Lee, Jung Hyun Lee, Yongjae Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.

Original languageEnglish
Pages (from-to)1197-1203
Number of pages7
JournalRespiratory Medicine
Volume104
Issue number8
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Body Composition
C-Reactive Protein
Lung
Inflammation
Adipose Tissue
Obesity
Odds Ratio
Confidence Intervals
Confounding Factors (Epidemiology)
Cross-Sectional Studies
Fats

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Jung, Dong Hyuk ; Shim, Jae Yong ; Ahn, Hong Yup ; Lee, Hye Ree ; Lee, Jung Hyun ; Lee, Yongjae. / Relationship of body composition and C-reactive protein with pulmonary function. In: Respiratory Medicine. 2010 ; Vol. 104, No. 8. pp. 1197-1203.
@article{88ef34adbb894c6ab39b0f24b5a3b5ba,
title = "Relationship of body composition and C-reactive protein with pulmonary function",
abstract = "Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95{\%} confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95{\%} CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.",
author = "Jung, {Dong Hyuk} and Shim, {Jae Yong} and Ahn, {Hong Yup} and Lee, {Hye Ree} and Lee, {Jung Hyun} and Yongjae Lee",
year = "2010",
month = "8",
day = "1",
doi = "10.1016/j.rmed.2010.02.014",
language = "English",
volume = "104",
pages = "1197--1203",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",
number = "8",

}

Relationship of body composition and C-reactive protein with pulmonary function. / Jung, Dong Hyuk; Shim, Jae Yong; Ahn, Hong Yup; Lee, Hye Ree; Lee, Jung Hyun; Lee, Yongjae.

In: Respiratory Medicine, Vol. 104, No. 8, 01.08.2010, p. 1197-1203.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship of body composition and C-reactive protein with pulmonary function

AU - Jung, Dong Hyuk

AU - Shim, Jae Yong

AU - Ahn, Hong Yup

AU - Lee, Hye Ree

AU - Lee, Jung Hyun

AU - Lee, Yongjae

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.

AB - Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.

UR - http://www.scopus.com/inward/record.url?scp=77953232646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953232646&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2010.02.014

DO - 10.1016/j.rmed.2010.02.014

M3 - Article

C2 - 20299196

AN - SCOPUS:77953232646

VL - 104

SP - 1197

EP - 1203

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 8

ER -