Abstract
Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.
| Original language | English |
|---|---|
| Pages (from-to) | 1197-1203 |
| Number of pages | 7 |
| Journal | Respiratory Medicine |
| Volume | 104 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2010 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
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Relationship of body composition and C-reactive protein with pulmonary function. / Jung, Dong Hyuk; Shim, Jae Yong; Ahn, Hong Yup; Lee, Hye Ree; Lee, Jung Hyun; Lee, Yong Jae.
In: Respiratory Medicine, Vol. 104, No. 8, 01.08.2010, p. 1197-1203.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship of body composition and C-reactive protein with pulmonary function
AU - Jung, Dong Hyuk
AU - Shim, Jae Yong
AU - Ahn, Hong Yup
AU - Lee, Hye Ree
AU - Lee, Jung Hyun
AU - Lee, Yong Jae
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.
AB - Objectives: It has been observed that restrictive pulmonary function is associated with obesity and C-reactive protein (CRP), an indicator for systemic inflammation. However, the interrelationship among body composition, CRP, and restrictive pulmonary function has been poorly understood. This study focused on the combined effects of body composition and CRP on restrictive pulmonary function. Methods: We performed a cross-sectional study to examine the association of body composition and CRP with restrictive pulmonary function in 12,787 subjects (7083 men, 5704 women; ages 20-75 yr). We evaluated body composition and CRP as a categorical variable (non-obesity, percentage body fat ≤75 percentile; obesity, percentage body fat >75 percentile; low-inflammation, CRP ≤75 percentile; high-inflammation, CRP >75 percentile) and constructed 4 groups, which were non-overlapping (reference, inflammatory, obese, obese and inflammatory). The odds ratios (ORs) and 95% confidence intervals (CIs) for restrictive pulmonary function were calculated across all 4 groups. Results: The adjusted ORs (95% CIs) for restrictive pulmonary function according to the 4 groups were 1.00(reference), 1.19(0.93-1.52), 2.01(1.53-2.64) and 3.51(2.60-4.74) in men and 1.00 (reference), 1.26 (0.96-1.69), 1.02 (0.58-1.81), and 3.32 (2.09-5.27) in women after adjusting for confounding variables. Interaction was found between the body fat percentage and CRP in women only (P < 0.05). Conclusions: In summary, the coexistence of high fat accumulation and systemic subclinical inflammation is associated with restrictive pulmonary function.
UR - http://www.scopus.com/inward/record.url?scp=77953232646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953232646&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2010.02.014
DO - 10.1016/j.rmed.2010.02.014
M3 - Article
C2 - 20299196
AN - SCOPUS:77953232646
VL - 104
SP - 1197
EP - 1203
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 8
ER -