Relationship of hemodynamic indices and prognosis in patients with liver cirrhosis

Soonkoo Baik, Myeong Gwan Jee, Phil Ho Jeong, Jae Woo Kim, Sang Won Ji, Hyunsoo Kim, DongKi Lee, Sang Ok Kwon, Young Ju Kim, Joong Wha Park, Sei Jin Chang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Hyperdynamic circulation due to reduced peripheral vascular resistance and increased cardiac output, and the development of portal hypertension are the hemodynamic changes observed in patients with liver cirrhosis. Such hemodynamic abnormalities appear in patients with late stage liver cirrhosis. Therefore, hemodynamic indices, which represent hyperdynamic circulation and portal hypertension, are significant for the prognosis of patients with liver cirrhosis. The aim of this study was to determine the hemodynamic indices associated with the prognosis of patients with liver cirrhosis. Methods: A total of 103 patients diagnosed with liver cirrhosis between December 1999 and June 2003, with a mean follow-up period of 73 weeks, ranging from 7 to 168 weeks, were recruited. Using Child-Pugh classification, the mean arterial pressure, heart rate and hepatic venous pressure gradient (HVPG) were measured. The indices of Doppler ultrasonography, including the portal and splenic venous flows, and the resistance of the hepatic, splenic, and renal arteries were also measured using the arterial pulsatility index (PI). The prognostic values of these indices were determined by their comparison with the patient survivals. Results: Significant hemodynamic indices for a bad prognosis were high HVPG (≥ 15 mmHg) and renal arterial PI (≥1.14)(p<0.05). A Child-Pugh score ≥10 was important for a poor prognosis (p<0.05). Conclusion: Severe portal hypertension (HVPG≥15 mmHg) and high renal arterial resistance (PI≥1.14) were valuable hemodynamic indices for the prognosis of patients with liver cirrhosis. Therefore, it was concluded that the measurement of these hemodynamic indices, in addition to the Child-Pugh classification, is helpful in the prognosis of patients with liver cirrhosis.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalKorean Journal of Internal Medicine
Volume19
Issue number3
DOIs
Publication statusPublished - 2004 Jan 1

Fingerprint

Liver Cirrhosis
Hemodynamics
Portal Hypertension
Venous Pressure
Vascular Resistance
Kidney
Splenic Artery
Doppler Ultrasonography
Liver
Hepatic Artery
Renal Artery
Cardiac Output
Arterial Pressure
Heart Rate
Survival

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Baik, Soonkoo ; Jee, Myeong Gwan ; Jeong, Phil Ho ; Kim, Jae Woo ; Ji, Sang Won ; Kim, Hyunsoo ; Lee, DongKi ; Kwon, Sang Ok ; Kim, Young Ju ; Park, Joong Wha ; Chang, Sei Jin. / Relationship of hemodynamic indices and prognosis in patients with liver cirrhosis. In: Korean Journal of Internal Medicine. 2004 ; Vol. 19, No. 3. pp. 165-170.
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abstract = "Background: Hyperdynamic circulation due to reduced peripheral vascular resistance and increased cardiac output, and the development of portal hypertension are the hemodynamic changes observed in patients with liver cirrhosis. Such hemodynamic abnormalities appear in patients with late stage liver cirrhosis. Therefore, hemodynamic indices, which represent hyperdynamic circulation and portal hypertension, are significant for the prognosis of patients with liver cirrhosis. The aim of this study was to determine the hemodynamic indices associated with the prognosis of patients with liver cirrhosis. Methods: A total of 103 patients diagnosed with liver cirrhosis between December 1999 and June 2003, with a mean follow-up period of 73 weeks, ranging from 7 to 168 weeks, were recruited. Using Child-Pugh classification, the mean arterial pressure, heart rate and hepatic venous pressure gradient (HVPG) were measured. The indices of Doppler ultrasonography, including the portal and splenic venous flows, and the resistance of the hepatic, splenic, and renal arteries were also measured using the arterial pulsatility index (PI). The prognostic values of these indices were determined by their comparison with the patient survivals. Results: Significant hemodynamic indices for a bad prognosis were high HVPG (≥ 15 mmHg) and renal arterial PI (≥1.14)(p<0.05). A Child-Pugh score ≥10 was important for a poor prognosis (p<0.05). Conclusion: Severe portal hypertension (HVPG≥15 mmHg) and high renal arterial resistance (PI≥1.14) were valuable hemodynamic indices for the prognosis of patients with liver cirrhosis. Therefore, it was concluded that the measurement of these hemodynamic indices, in addition to the Child-Pugh classification, is helpful in the prognosis of patients with liver cirrhosis.",
author = "Soonkoo Baik and Jee, {Myeong Gwan} and Jeong, {Phil Ho} and Kim, {Jae Woo} and Ji, {Sang Won} and Hyunsoo Kim and DongKi Lee and Kwon, {Sang Ok} and Kim, {Young Ju} and Park, {Joong Wha} and Chang, {Sei Jin}",
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Relationship of hemodynamic indices and prognosis in patients with liver cirrhosis. / Baik, Soonkoo; Jee, Myeong Gwan; Jeong, Phil Ho; Kim, Jae Woo; Ji, Sang Won; Kim, Hyunsoo; Lee, DongKi; Kwon, Sang Ok; Kim, Young Ju; Park, Joong Wha; Chang, Sei Jin.

In: Korean Journal of Internal Medicine, Vol. 19, No. 3, 01.01.2004, p. 165-170.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship of hemodynamic indices and prognosis in patients with liver cirrhosis

AU - Baik, Soonkoo

AU - Jee, Myeong Gwan

AU - Jeong, Phil Ho

AU - Kim, Jae Woo

AU - Ji, Sang Won

AU - Kim, Hyunsoo

AU - Lee, DongKi

AU - Kwon, Sang Ok

AU - Kim, Young Ju

AU - Park, Joong Wha

AU - Chang, Sei Jin

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background: Hyperdynamic circulation due to reduced peripheral vascular resistance and increased cardiac output, and the development of portal hypertension are the hemodynamic changes observed in patients with liver cirrhosis. Such hemodynamic abnormalities appear in patients with late stage liver cirrhosis. Therefore, hemodynamic indices, which represent hyperdynamic circulation and portal hypertension, are significant for the prognosis of patients with liver cirrhosis. The aim of this study was to determine the hemodynamic indices associated with the prognosis of patients with liver cirrhosis. Methods: A total of 103 patients diagnosed with liver cirrhosis between December 1999 and June 2003, with a mean follow-up period of 73 weeks, ranging from 7 to 168 weeks, were recruited. Using Child-Pugh classification, the mean arterial pressure, heart rate and hepatic venous pressure gradient (HVPG) were measured. The indices of Doppler ultrasonography, including the portal and splenic venous flows, and the resistance of the hepatic, splenic, and renal arteries were also measured using the arterial pulsatility index (PI). The prognostic values of these indices were determined by their comparison with the patient survivals. Results: Significant hemodynamic indices for a bad prognosis were high HVPG (≥ 15 mmHg) and renal arterial PI (≥1.14)(p<0.05). A Child-Pugh score ≥10 was important for a poor prognosis (p<0.05). Conclusion: Severe portal hypertension (HVPG≥15 mmHg) and high renal arterial resistance (PI≥1.14) were valuable hemodynamic indices for the prognosis of patients with liver cirrhosis. Therefore, it was concluded that the measurement of these hemodynamic indices, in addition to the Child-Pugh classification, is helpful in the prognosis of patients with liver cirrhosis.

AB - Background: Hyperdynamic circulation due to reduced peripheral vascular resistance and increased cardiac output, and the development of portal hypertension are the hemodynamic changes observed in patients with liver cirrhosis. Such hemodynamic abnormalities appear in patients with late stage liver cirrhosis. Therefore, hemodynamic indices, which represent hyperdynamic circulation and portal hypertension, are significant for the prognosis of patients with liver cirrhosis. The aim of this study was to determine the hemodynamic indices associated with the prognosis of patients with liver cirrhosis. Methods: A total of 103 patients diagnosed with liver cirrhosis between December 1999 and June 2003, with a mean follow-up period of 73 weeks, ranging from 7 to 168 weeks, were recruited. Using Child-Pugh classification, the mean arterial pressure, heart rate and hepatic venous pressure gradient (HVPG) were measured. The indices of Doppler ultrasonography, including the portal and splenic venous flows, and the resistance of the hepatic, splenic, and renal arteries were also measured using the arterial pulsatility index (PI). The prognostic values of these indices were determined by their comparison with the patient survivals. Results: Significant hemodynamic indices for a bad prognosis were high HVPG (≥ 15 mmHg) and renal arterial PI (≥1.14)(p<0.05). A Child-Pugh score ≥10 was important for a poor prognosis (p<0.05). Conclusion: Severe portal hypertension (HVPG≥15 mmHg) and high renal arterial resistance (PI≥1.14) were valuable hemodynamic indices for the prognosis of patients with liver cirrhosis. Therefore, it was concluded that the measurement of these hemodynamic indices, in addition to the Child-Pugh classification, is helpful in the prognosis of patients with liver cirrhosis.

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