Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness

Ki Bum Won, Gyung Min Park, Sang Eun Lee, In Jeong Cho, Hyeon Chang Kim, Byoung Kwon Lee, Hyuk Jae Chang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.

Original languageEnglish
Article number268
JournalLipids in Health and Disease
Volume17
Issue number1
DOIs
Publication statusPublished - 2018 Nov 24

Fingerprint

Vascular Stiffness
Pulse Wave Analysis
Insulin Resistance
Triglycerides
Stiffness
Insulin
Ankle
Glucose
Arm
Blood pressure
Medical problems
Regression analysis
Coronary Artery Disease
Atherosclerosis
Cohort Studies
Biomarkers
Stroke
Regression Analysis
Blood Pressure
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Won, Ki Bum ; Park, Gyung Min ; Lee, Sang Eun ; Cho, In Jeong ; Kim, Hyeon Chang ; Lee, Byoung Kwon ; Chang, Hyuk Jae. / Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness. In: Lipids in Health and Disease. 2018 ; Vol. 17, No. 1.
@article{5a1e7b4bf6114f298dd19b785bea2c0a,
title = "Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness",
abstract = "Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.",
author = "Won, {Ki Bum} and Park, {Gyung Min} and Lee, {Sang Eun} and Cho, {In Jeong} and Kim, {Hyeon Chang} and Lee, {Byoung Kwon} and Chang, {Hyuk Jae}",
year = "2018",
month = "11",
day = "24",
doi = "10.1186/s12944-018-0914-2",
language = "English",
volume = "17",
journal = "Lipids in Health and Disease",
issn = "1476-511X",
publisher = "BioMed Central",
number = "1",

}

Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness. / Won, Ki Bum; Park, Gyung Min; Lee, Sang Eun; Cho, In Jeong; Kim, Hyeon Chang; Lee, Byoung Kwon; Chang, Hyuk Jae.

In: Lipids in Health and Disease, Vol. 17, No. 1, 268, 24.11.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness

AU - Won, Ki Bum

AU - Park, Gyung Min

AU - Lee, Sang Eun

AU - Cho, In Jeong

AU - Kim, Hyeon Chang

AU - Lee, Byoung Kwon

AU - Chang, Hyuk Jae

PY - 2018/11/24

Y1 - 2018/11/24

N2 - Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.

AB - Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.

UR - http://www.scopus.com/inward/record.url?scp=85057081152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057081152&partnerID=8YFLogxK

U2 - 10.1186/s12944-018-0914-2

DO - 10.1186/s12944-018-0914-2

M3 - Article

C2 - 30474549

AN - SCOPUS:85057081152

VL - 17

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

SN - 1476-511X

IS - 1

M1 - 268

ER -