Abstract
Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.
| Original language | English |
|---|---|
| Article number | 268 |
| Journal | Lipids in Health and Disease |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 Nov 24 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
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Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness. / Won, Ki Bum; Park, Gyung Min; Lee, Sang Eun; Cho, In Jeong; Kim, Hyeon Chang; Lee, Byoung Kwon; Chang, Hyuk Jae.
In: Lipids in Health and Disease, Vol. 17, No. 1, 268, 24.11.2018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness
AU - Won, Ki Bum
AU - Park, Gyung Min
AU - Lee, Sang Eun
AU - Cho, In Jeong
AU - Kim, Hyeon Chang
AU - Lee, Byoung Kwon
AU - Chang, Hyuk Jae
PY - 2018/11/24
Y1 - 2018/11/24
N2 - Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.
AB - Background: Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness. Methods: This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). Results: All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics. Conclusions: The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.
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U2 - 10.1186/s12944-018-0914-2
DO - 10.1186/s12944-018-0914-2
M3 - Article
C2 - 30474549
AN - SCOPUS:85057081152
VL - 17
JO - Lipids in Health and Disease
JF - Lipids in Health and Disease
SN - 1476-511X
IS - 1
M1 - 268
ER -