Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.
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Conflict of interests: Dr. Min received modest speakers’ bureau and medical advisory board compensation and significant research support from GE Healthcare . Dr. Achenbach received grant support from Siemens and Bayer Schering Pharma and has served as a consultant for Servier. Dr. Cademartiri received grant support from GE Healthcare and has served on the Speakers’ Bureau of Bracco and as a consultant for Servier. Dr. Chinnaiyan received grant support from the American Heart Association . Dr. Chow received research and fellowship support from GE Healthcare and educational support from TeraRecon . Dr. Hausleiter received a research grant from Siemens Medical Systems and has served on the Speakers’ Bureau of Abbott Vascular. Dr. Maffei received grant support from GE Healthcare . Dr. Raff received grant support from Siemens . All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
This study was supported in part by the Michael Wolk Foundation .
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine