Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography

Ryo Nakazato, Heidi Gransar, Daniel S. Berman, Victor Y. Cheng, Fay Y. Lin, Stephan Achenbach, Mouaz Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk Jae Chang, Kavitha Chinnaiyan, Benjamin J.W. Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Erica Maffei, Gilbert Raff, Leslee J. ShawTodd C. Villines, Allison Dunning, Ricardo C. Cury, Gudrun Feuchtner, Yong Jin Kim, Jonathon Leipsic, James K. Min

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalJournal of Cardiovascular Computed Tomography
Volume7
Issue number2
DOIs
Publication statusPublished - 2013 Mar 1

Fingerprint

HDL Lipoproteins
Lipoproteins
Coronary Vessels
LDL Lipoproteins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HDL Cholesterol
Angiography
Odds Ratio
Computed Tomography Angiography
Multicenter Studies
Coronary Artery Disease
Cholesterol
Lipids

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Nakazato, Ryo ; Gransar, Heidi ; Berman, Daniel S. ; Cheng, Victor Y. ; Lin, Fay Y. ; Achenbach, Stephan ; Al-Mallah, Mouaz ; Budoff, Matthew J. ; Cademartiri, Filippo ; Callister, Tracy Q. ; Chang, Hyuk Jae ; Chinnaiyan, Kavitha ; Chow, Benjamin J.W. ; Delago, Augustin ; Hadamitzky, Martin ; Hausleiter, Joerg ; Kaufmann, Philipp ; Maffei, Erica ; Raff, Gilbert ; Shaw, Leslee J. ; Villines, Todd C. ; Dunning, Allison ; Cury, Ricardo C. ; Feuchtner, Gudrun ; Kim, Yong Jin ; Leipsic, Jonathon ; Min, James K. / Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography. In: Journal of Cardiovascular Computed Tomography. 2013 ; Vol. 7, No. 2. pp. 83-90.
@article{fb89ac1404824b39bf884adaedcaa770,
title = "Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography",
abstract = "Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55{\%} men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95{\%} CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95{\%} CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95{\%} CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.",
author = "Ryo Nakazato and Heidi Gransar and Berman, {Daniel S.} and Cheng, {Victor Y.} and Lin, {Fay Y.} and Stephan Achenbach and Mouaz Al-Mallah and Budoff, {Matthew J.} and Filippo Cademartiri and Callister, {Tracy Q.} and Chang, {Hyuk Jae} and Kavitha Chinnaiyan and Chow, {Benjamin J.W.} and Augustin Delago and Martin Hadamitzky and Joerg Hausleiter and Philipp Kaufmann and Erica Maffei and Gilbert Raff and Shaw, {Leslee J.} and Villines, {Todd C.} and Allison Dunning and Cury, {Ricardo C.} and Gudrun Feuchtner and Kim, {Yong Jin} and Jonathon Leipsic and Min, {James K.}",
year = "2013",
month = "3",
day = "1",
doi = "10.1016/j.jcct.2013.01.008",
language = "English",
volume = "7",
pages = "83--90",
journal = "Journal of Cardiovascular Computed Tomography",
issn = "1934-5925",
publisher = "Elsevier Inc.",
number = "2",

}

Nakazato, R, Gransar, H, Berman, DS, Cheng, VY, Lin, FY, Achenbach, S, Al-Mallah, M, Budoff, MJ, Cademartiri, F, Callister, TQ, Chang, HJ, Chinnaiyan, K, Chow, BJW, Delago, A, Hadamitzky, M, Hausleiter, J, Kaufmann, P, Maffei, E, Raff, G, Shaw, LJ, Villines, TC, Dunning, A, Cury, RC, Feuchtner, G, Kim, YJ, Leipsic, J & Min, JK 2013, 'Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography', Journal of Cardiovascular Computed Tomography, vol. 7, no. 2, pp. 83-90. https://doi.org/10.1016/j.jcct.2013.01.008

Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography. / Nakazato, Ryo; Gransar, Heidi; Berman, Daniel S.; Cheng, Victor Y.; Lin, Fay Y.; Achenbach, Stephan; Al-Mallah, Mouaz; Budoff, Matthew J.; Cademartiri, Filippo; Callister, Tracy Q.; Chang, Hyuk Jae; Chinnaiyan, Kavitha; Chow, Benjamin J.W.; Delago, Augustin; Hadamitzky, Martin; Hausleiter, Joerg; Kaufmann, Philipp; Maffei, Erica; Raff, Gilbert; Shaw, Leslee J.; Villines, Todd C.; Dunning, Allison; Cury, Ricardo C.; Feuchtner, Gudrun; Kim, Yong Jin; Leipsic, Jonathon; Min, James K.

In: Journal of Cardiovascular Computed Tomography, Vol. 7, No. 2, 01.03.2013, p. 83-90.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography

AU - Nakazato, Ryo

AU - Gransar, Heidi

AU - Berman, Daniel S.

AU - Cheng, Victor Y.

AU - Lin, Fay Y.

AU - Achenbach, Stephan

AU - Al-Mallah, Mouaz

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Callister, Tracy Q.

AU - Chang, Hyuk Jae

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin J.W.

AU - Delago, Augustin

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Kaufmann, Philipp

AU - Maffei, Erica

AU - Raff, Gilbert

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Dunning, Allison

AU - Cury, Ricardo C.

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Leipsic, Jonathon

AU - Min, James K.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.

AB - Background: The association between lipoprotein levels and coronary plaque composition is not well understood. Objective: The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA). Methods: We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque). Results: Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP. Conclusion: NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.

UR - http://www.scopus.com/inward/record.url?scp=84876828443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876828443&partnerID=8YFLogxK

U2 - 10.1016/j.jcct.2013.01.008

DO - 10.1016/j.jcct.2013.01.008

M3 - Article

C2 - 23622503

AN - SCOPUS:84876828443

VL - 7

SP - 83

EP - 90

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

IS - 2

ER -