Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: A case-control study

Hanbyoul Cho, Mi Kyung Kim, Jae Kwan Lee, Sung Kyong Son, Kwang Beom Lee, Jong Min Lee, Jung Pil Lee, Soo Young Hur, Jae-Hoon Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. Methods: The study population included women with histopathological diagnosis of cervical intraepithelial neoplasia (CIN) 1 (n=147), CIN 2/3 (n=177), cervical cancer (n=160), and a control group (n=378). Epidemiological data were collected and the serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol were measured using reverse-phase, gradient high-pressure liquid chromatography. Results: Cervical cancer was found to be associated with older age, increased body mass index, and lower socioeconomic status as measured by education level and income. The mean serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol of cervical cancer patients were significantly lower than those of control subjects. Odds ratio adjusted for age, smoking status, alcohol consumption, and human papillomavirus infection status revealed a significant gradient of decreasing risk of CIN 1, CIN 2/3, and cervical cancer with increasing serum concentrations of most antioxidant micronutrients. Conclusions: The results of this study show an inverse association between serum antioxidant micronutrient concentrations and the risk of cervical neoplasia. These results suggest that antioxidant micronutrients play a role in the prevention of cervical carcinogenesis.

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Volume47
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

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Micronutrients
Cervical Intraepithelial Neoplasia
Tocopherols
Case-Control Studies
Antioxidants
Uterine Cervical Neoplasms
Lutein
Serum
Carotenoids
Neoplasms
Vitamin A
Carcinogenesis
High pressure liquid chromatography
Papillomavirus Infections
Nutrition
Nutritional Status
Social Class
Alcohol Drinking
Epidemiologic Studies
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Cho, Hanbyoul ; Kim, Mi Kyung ; Lee, Jae Kwan ; Son, Sung Kyong ; Lee, Kwang Beom ; Lee, Jong Min ; Lee, Jung Pil ; Hur, Soo Young ; Kim, Jae-Hoon. / Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia : A case-control study. In: Clinical Chemistry and Laboratory Medicine. 2009 ; Vol. 47, No. 8. pp. 1005-1012.
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abstract = "Background: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. Methods: The study population included women with histopathological diagnosis of cervical intraepithelial neoplasia (CIN) 1 (n=147), CIN 2/3 (n=177), cervical cancer (n=160), and a control group (n=378). Epidemiological data were collected and the serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol were measured using reverse-phase, gradient high-pressure liquid chromatography. Results: Cervical cancer was found to be associated with older age, increased body mass index, and lower socioeconomic status as measured by education level and income. The mean serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol of cervical cancer patients were significantly lower than those of control subjects. Odds ratio adjusted for age, smoking status, alcohol consumption, and human papillomavirus infection status revealed a significant gradient of decreasing risk of CIN 1, CIN 2/3, and cervical cancer with increasing serum concentrations of most antioxidant micronutrients. Conclusions: The results of this study show an inverse association between serum antioxidant micronutrient concentrations and the risk of cervical neoplasia. These results suggest that antioxidant micronutrients play a role in the prevention of cervical carcinogenesis.",
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Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia : A case-control study. / Cho, Hanbyoul; Kim, Mi Kyung; Lee, Jae Kwan; Son, Sung Kyong; Lee, Kwang Beom; Lee, Jong Min; Lee, Jung Pil; Hur, Soo Young; Kim, Jae-Hoon.

In: Clinical Chemistry and Laboratory Medicine, Vol. 47, No. 8, 01.08.2009, p. 1005-1012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia

T2 - A case-control study

AU - Cho, Hanbyoul

AU - Kim, Mi Kyung

AU - Lee, Jae Kwan

AU - Son, Sung Kyong

AU - Lee, Kwang Beom

AU - Lee, Jong Min

AU - Lee, Jung Pil

AU - Hur, Soo Young

AU - Kim, Jae-Hoon

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. Methods: The study population included women with histopathological diagnosis of cervical intraepithelial neoplasia (CIN) 1 (n=147), CIN 2/3 (n=177), cervical cancer (n=160), and a control group (n=378). Epidemiological data were collected and the serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol were measured using reverse-phase, gradient high-pressure liquid chromatography. Results: Cervical cancer was found to be associated with older age, increased body mass index, and lower socioeconomic status as measured by education level and income. The mean serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol of cervical cancer patients were significantly lower than those of control subjects. Odds ratio adjusted for age, smoking status, alcohol consumption, and human papillomavirus infection status revealed a significant gradient of decreasing risk of CIN 1, CIN 2/3, and cervical cancer with increasing serum concentrations of most antioxidant micronutrients. Conclusions: The results of this study show an inverse association between serum antioxidant micronutrient concentrations and the risk of cervical neoplasia. These results suggest that antioxidant micronutrients play a role in the prevention of cervical carcinogenesis.

AB - Background: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. Methods: The study population included women with histopathological diagnosis of cervical intraepithelial neoplasia (CIN) 1 (n=147), CIN 2/3 (n=177), cervical cancer (n=160), and a control group (n=378). Epidemiological data were collected and the serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol were measured using reverse-phase, gradient high-pressure liquid chromatography. Results: Cervical cancer was found to be associated with older age, increased body mass index, and lower socioeconomic status as measured by education level and income. The mean serum concentrations of β-carotene, lycopene, zeaxanthin plus lutein, retinol, α-tocopherol, and γ-tocopherol of cervical cancer patients were significantly lower than those of control subjects. Odds ratio adjusted for age, smoking status, alcohol consumption, and human papillomavirus infection status revealed a significant gradient of decreasing risk of CIN 1, CIN 2/3, and cervical cancer with increasing serum concentrations of most antioxidant micronutrients. Conclusions: The results of this study show an inverse association between serum antioxidant micronutrient concentrations and the risk of cervical neoplasia. These results suggest that antioxidant micronutrients play a role in the prevention of cervical carcinogenesis.

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