Relationships among the lactulose breath test, intestinal gas volume, and gastrointestinal symptoms in patients with irritable bowel syndrome

Young Hoon Youn, Jung Soo Park, Jae Hoon Jahng, Hyun Chul Lim, Jie Hyun Kim, Mark Pimentel, Hyojin Park, Sang In Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and Aims: Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointestinal symptom score in healthy control and functional bowel disorder (FBD) subjects. Method: In 84 IBS subjects, 24 FBD subjects other than IBS, and 25 healthy controls, a symptom questionnaire that enquired about seven main symptoms, plain abdominal radiography and a LBT were checked on the same day. The intestinal gas volume was calculated as the gas volume score (GVS) with a digitalized image of plain supine abdominal radiographs. Results: The GVS was greater in the LBT (+) group compared to the LBT (-) group (P = 0.02). The GVS was greater in the FBD and IBS groups than in the control group (P < 0.01). The GVS showed low but positive correlations with the severity and frequency of bloating, flatulence, abdominal pain, constipation, and tenesmus (P < 0.05). The severity of flatulence (P = 0.02) and the frequency of bloating (P = 0.02) in the LBT (+) group were significantly higher than those in the LBT (-) group. Conclusions: Subjects with positive LBT had more gas-related symptoms and greater gas volume scores. Gas-related symptoms, positive LBT and increased GVS were significantly associated to each other. These findings can broaden the understanding of the pathophysiologic mechanisms of gas-related symptoms in IBS.

Original languageEnglish
Pages (from-to)2059-2066
Number of pages8
JournalDigestive diseases and sciences
Volume56
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Lactulose
Breath Tests
Irritable Bowel Syndrome
Gases
Flatulence
Abdominal Radiography
Constipation
Abdominal Pain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Youn, Young Hoon ; Park, Jung Soo ; Jahng, Jae Hoon ; Lim, Hyun Chul ; Kim, Jie Hyun ; Pimentel, Mark ; Park, Hyojin ; Lee, Sang In. / Relationships among the lactulose breath test, intestinal gas volume, and gastrointestinal symptoms in patients with irritable bowel syndrome. In: Digestive diseases and sciences. 2011 ; Vol. 56, No. 7. pp. 2059-2066.
@article{605c74832c1e41389e7a5c4c76d2e806,
title = "Relationships among the lactulose breath test, intestinal gas volume, and gastrointestinal symptoms in patients with irritable bowel syndrome",
abstract = "Background and Aims: Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointestinal symptom score in healthy control and functional bowel disorder (FBD) subjects. Method: In 84 IBS subjects, 24 FBD subjects other than IBS, and 25 healthy controls, a symptom questionnaire that enquired about seven main symptoms, plain abdominal radiography and a LBT were checked on the same day. The intestinal gas volume was calculated as the gas volume score (GVS) with a digitalized image of plain supine abdominal radiographs. Results: The GVS was greater in the LBT (+) group compared to the LBT (-) group (P = 0.02). The GVS was greater in the FBD and IBS groups than in the control group (P < 0.01). The GVS showed low but positive correlations with the severity and frequency of bloating, flatulence, abdominal pain, constipation, and tenesmus (P < 0.05). The severity of flatulence (P = 0.02) and the frequency of bloating (P = 0.02) in the LBT (+) group were significantly higher than those in the LBT (-) group. Conclusions: Subjects with positive LBT had more gas-related symptoms and greater gas volume scores. Gas-related symptoms, positive LBT and increased GVS were significantly associated to each other. These findings can broaden the understanding of the pathophysiologic mechanisms of gas-related symptoms in IBS.",
author = "Youn, {Young Hoon} and Park, {Jung Soo} and Jahng, {Jae Hoon} and Lim, {Hyun Chul} and Kim, {Jie Hyun} and Mark Pimentel and Hyojin Park and Lee, {Sang In}",
year = "2011",
month = "7",
day = "1",
doi = "10.1007/s10620-011-1569-2",
language = "English",
volume = "56",
pages = "2059--2066",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "7",

}

Relationships among the lactulose breath test, intestinal gas volume, and gastrointestinal symptoms in patients with irritable bowel syndrome. / Youn, Young Hoon; Park, Jung Soo; Jahng, Jae Hoon; Lim, Hyun Chul; Kim, Jie Hyun; Pimentel, Mark; Park, Hyojin; Lee, Sang In.

In: Digestive diseases and sciences, Vol. 56, No. 7, 01.07.2011, p. 2059-2066.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationships among the lactulose breath test, intestinal gas volume, and gastrointestinal symptoms in patients with irritable bowel syndrome

AU - Youn, Young Hoon

AU - Park, Jung Soo

AU - Jahng, Jae Hoon

AU - Lim, Hyun Chul

AU - Kim, Jie Hyun

AU - Pimentel, Mark

AU - Park, Hyojin

AU - Lee, Sang In

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Background and Aims: Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointestinal symptom score in healthy control and functional bowel disorder (FBD) subjects. Method: In 84 IBS subjects, 24 FBD subjects other than IBS, and 25 healthy controls, a symptom questionnaire that enquired about seven main symptoms, plain abdominal radiography and a LBT were checked on the same day. The intestinal gas volume was calculated as the gas volume score (GVS) with a digitalized image of plain supine abdominal radiographs. Results: The GVS was greater in the LBT (+) group compared to the LBT (-) group (P = 0.02). The GVS was greater in the FBD and IBS groups than in the control group (P < 0.01). The GVS showed low but positive correlations with the severity and frequency of bloating, flatulence, abdominal pain, constipation, and tenesmus (P < 0.05). The severity of flatulence (P = 0.02) and the frequency of bloating (P = 0.02) in the LBT (+) group were significantly higher than those in the LBT (-) group. Conclusions: Subjects with positive LBT had more gas-related symptoms and greater gas volume scores. Gas-related symptoms, positive LBT and increased GVS were significantly associated to each other. These findings can broaden the understanding of the pathophysiologic mechanisms of gas-related symptoms in IBS.

AB - Background and Aims: Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointestinal symptom score in healthy control and functional bowel disorder (FBD) subjects. Method: In 84 IBS subjects, 24 FBD subjects other than IBS, and 25 healthy controls, a symptom questionnaire that enquired about seven main symptoms, plain abdominal radiography and a LBT were checked on the same day. The intestinal gas volume was calculated as the gas volume score (GVS) with a digitalized image of plain supine abdominal radiographs. Results: The GVS was greater in the LBT (+) group compared to the LBT (-) group (P = 0.02). The GVS was greater in the FBD and IBS groups than in the control group (P < 0.01). The GVS showed low but positive correlations with the severity and frequency of bloating, flatulence, abdominal pain, constipation, and tenesmus (P < 0.05). The severity of flatulence (P = 0.02) and the frequency of bloating (P = 0.02) in the LBT (+) group were significantly higher than those in the LBT (-) group. Conclusions: Subjects with positive LBT had more gas-related symptoms and greater gas volume scores. Gas-related symptoms, positive LBT and increased GVS were significantly associated to each other. These findings can broaden the understanding of the pathophysiologic mechanisms of gas-related symptoms in IBS.

UR - http://www.scopus.com/inward/record.url?scp=79959687658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959687658&partnerID=8YFLogxK

U2 - 10.1007/s10620-011-1569-2

DO - 10.1007/s10620-011-1569-2

M3 - Article

C2 - 21240630

AN - SCOPUS:79959687658

VL - 56

SP - 2059

EP - 2066

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 7

ER -