Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the Korean population

Eun Suk Jung, Seung Won Kim, Chang Mo Moon, Dong Jik Shin, Nak Hoon Son, Eun Soo Kim, Hyun Jung Lee, Sung Pil Hong, Tae Il Kim, Won Ho Kim, JaeHee Cheon

Research output: Contribution to journalArticle

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Abstract

Aims: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). Therefore, we investigated the associations between TREM-1 genetic polymorphisms and IBD development and its phenotypes in the Korean population. Main methods: Three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) were genotyped by Taqman technology on 202 Crohn's disease (CD), 265 ulcerative colitis (UC), 138 with intestinal Behcet's disease (BD), and 234 healthy controls and the relationships between these SNPs and IBD development and phenotypes were evaluated. Key findings: We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR] = 1.637, P = 0.025; rs3789205: OR = 1.668, P = 0.019; rs2234237: OR = 1.691, P = 0.016), and in particular with skin involvement (rs9471535: OR = 2.723, P = 0.009; rs3789205: OR = 2.477, P = 0.017; rs2234237: OR = 2.278, P = 0.030) and the risk of azathioprine use (rs9471535: OR = 2.722, P = 0.021; rs3789205: OR = 2.493, P = 0.032; rs2234237: OR = 2.638, P = 0.026). However, TREM-1 SNPs were not significantly associated with the development of Crohn's disease or ulcerative colitis. Significance: The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet's disease and may have modest effects on disease severity.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalLife Sciences
Volume89
Issue number9-10
DOIs
Publication statusPublished - 2011 Aug 29

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Genetic Polymorphisms
Myeloid Cells
Polymorphism
Crohn Disease
Odds Ratio
Single Nucleotide Polymorphism
Population
Intestinal Diseases
Behcet Syndrome
Inflammatory Bowel Diseases
Ulcerative Colitis
Phenotype
Azathioprine
Skin
Nucleotides
Technology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Jung, Eun Suk ; Kim, Seung Won ; Moon, Chang Mo ; Shin, Dong Jik ; Son, Nak Hoon ; Kim, Eun Soo ; Lee, Hyun Jung ; Hong, Sung Pil ; Kim, Tae Il ; Kim, Won Ho ; Cheon, JaeHee. / Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the Korean population. In: Life Sciences. 2011 ; Vol. 89, No. 9-10. pp. 289-294.
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abstract = "Aims: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). Therefore, we investigated the associations between TREM-1 genetic polymorphisms and IBD development and its phenotypes in the Korean population. Main methods: Three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) were genotyped by Taqman technology on 202 Crohn's disease (CD), 265 ulcerative colitis (UC), 138 with intestinal Behcet's disease (BD), and 234 healthy controls and the relationships between these SNPs and IBD development and phenotypes were evaluated. Key findings: We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR] = 1.637, P = 0.025; rs3789205: OR = 1.668, P = 0.019; rs2234237: OR = 1.691, P = 0.016), and in particular with skin involvement (rs9471535: OR = 2.723, P = 0.009; rs3789205: OR = 2.477, P = 0.017; rs2234237: OR = 2.278, P = 0.030) and the risk of azathioprine use (rs9471535: OR = 2.722, P = 0.021; rs3789205: OR = 2.493, P = 0.032; rs2234237: OR = 2.638, P = 0.026). However, TREM-1 SNPs were not significantly associated with the development of Crohn's disease or ulcerative colitis. Significance: The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet's disease and may have modest effects on disease severity.",
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Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the Korean population. / Jung, Eun Suk; Kim, Seung Won; Moon, Chang Mo; Shin, Dong Jik; Son, Nak Hoon; Kim, Eun Soo; Lee, Hyun Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, JaeHee.

In: Life Sciences, Vol. 89, No. 9-10, 29.08.2011, p. 289-294.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the Korean population

AU - Jung, Eun Suk

AU - Kim, Seung Won

AU - Moon, Chang Mo

AU - Shin, Dong Jik

AU - Son, Nak Hoon

AU - Kim, Eun Soo

AU - Lee, Hyun Jung

AU - Hong, Sung Pil

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Cheon, JaeHee

PY - 2011/8/29

Y1 - 2011/8/29

N2 - Aims: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). Therefore, we investigated the associations between TREM-1 genetic polymorphisms and IBD development and its phenotypes in the Korean population. Main methods: Three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) were genotyped by Taqman technology on 202 Crohn's disease (CD), 265 ulcerative colitis (UC), 138 with intestinal Behcet's disease (BD), and 234 healthy controls and the relationships between these SNPs and IBD development and phenotypes were evaluated. Key findings: We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR] = 1.637, P = 0.025; rs3789205: OR = 1.668, P = 0.019; rs2234237: OR = 1.691, P = 0.016), and in particular with skin involvement (rs9471535: OR = 2.723, P = 0.009; rs3789205: OR = 2.477, P = 0.017; rs2234237: OR = 2.278, P = 0.030) and the risk of azathioprine use (rs9471535: OR = 2.722, P = 0.021; rs3789205: OR = 2.493, P = 0.032; rs2234237: OR = 2.638, P = 0.026). However, TREM-1 SNPs were not significantly associated with the development of Crohn's disease or ulcerative colitis. Significance: The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet's disease and may have modest effects on disease severity.

AB - Aims: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). Therefore, we investigated the associations between TREM-1 genetic polymorphisms and IBD development and its phenotypes in the Korean population. Main methods: Three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) were genotyped by Taqman technology on 202 Crohn's disease (CD), 265 ulcerative colitis (UC), 138 with intestinal Behcet's disease (BD), and 234 healthy controls and the relationships between these SNPs and IBD development and phenotypes were evaluated. Key findings: We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR] = 1.637, P = 0.025; rs3789205: OR = 1.668, P = 0.019; rs2234237: OR = 1.691, P = 0.016), and in particular with skin involvement (rs9471535: OR = 2.723, P = 0.009; rs3789205: OR = 2.477, P = 0.017; rs2234237: OR = 2.278, P = 0.030) and the risk of azathioprine use (rs9471535: OR = 2.722, P = 0.021; rs3789205: OR = 2.493, P = 0.032; rs2234237: OR = 2.638, P = 0.026). However, TREM-1 SNPs were not significantly associated with the development of Crohn's disease or ulcerative colitis. Significance: The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet's disease and may have modest effects on disease severity.

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