Relative contribution of obesity and serum adiponectin to the development of hypertension

Dong Hyuk Jung, Jang Young Kim, Jong Koo Kim, Sang Baek Koh, Jong Ku Park, Song Vogue Ahn

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10 Citations (Scopus)

Abstract

Aims: The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women. Methods: We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 'high adiponectin'. Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin. Results: During an average of 2.6 years of follow-up, 79 men (13.5%) and 99 women (10.2%) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95% CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95% CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95% CI 1.16-5.04). Conclusion: Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume103
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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