Relative contribution of obesity and serum adiponectin to the development of hypertension

Dong Hyuk Jung, Jang Young Kim, Jong Koo Kim, Sang Baek Koh, Jong Ku Park, Song Vogue Ahn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims: The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women. Methods: We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 'high adiponectin'. Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin. Results: During an average of 2.6 years of follow-up, 79 men (13.5%) and 99 women (10.2%) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95% CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95% CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95% CI 1.16-5.04). Conclusion: Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume103
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Adiponectin
Obesity
Hypertension
Serum
Odds Ratio
Control Groups
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Jung, Dong Hyuk ; Kim, Jang Young ; Kim, Jong Koo ; Koh, Sang Baek ; Park, Jong Ku ; Ahn, Song Vogue. / Relative contribution of obesity and serum adiponectin to the development of hypertension. In: Diabetes Research and Clinical Practice. 2014 ; Vol. 103, No. 1. pp. 51-56.
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abstract = "Aims: The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women. Methods: We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 'high adiponectin'. Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin. Results: During an average of 2.6 years of follow-up, 79 men (13.5{\%}) and 99 women (10.2{\%}) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95{\%} CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95{\%} CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95{\%} CI 1.16-5.04). Conclusion: Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.",
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Relative contribution of obesity and serum adiponectin to the development of hypertension. / Jung, Dong Hyuk; Kim, Jang Young; Kim, Jong Koo; Koh, Sang Baek; Park, Jong Ku; Ahn, Song Vogue.

In: Diabetes Research and Clinical Practice, Vol. 103, No. 1, 01.01.2014, p. 51-56.

Research output: Contribution to journalArticle

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N2 - Aims: The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women. Methods: We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 'high adiponectin'. Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin. Results: During an average of 2.6 years of follow-up, 79 men (13.5%) and 99 women (10.2%) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95% CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95% CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95% CI 1.16-5.04). Conclusion: Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.

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