Reliability of breast ultrasound BI-RADS final assessment in mammographically negative patients with nipple discharge and radiologic predictors of malignancy

Chae Jung Park, Eun Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Min Jung Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The purpose of this study was to retrospectively investigate the reliability of breast ultrasound (US) Breast Imaging Reporting and Data System (BI-RADS) final assessment in mammographically negative patients with pathologic nipple discharge, and to determine the clinical and ultrasonographic variables associated with malignancy in this group of patients. Methods: A total of 65 patients with 67 mammographically negative breast lesions that were pathologically confirmed through US-guided biopsy were included. Results: Of the 53 BI-RADS category 4 and 5 lesions, eight (15.1%) were malignant (six ductal carcinomas in situ, one invasive ductal carcinoma, and one solid papillary carcinoma). There was no malignancy among the remaining 14 category 3 lesions. Malignant lesions more frequently displayed a round or irregular shape (75.0%, 6/8; p= 0.030) and nonparallel orientation (33.3%, 4/12; p= 0.029) compared to the benign lesions. The increase in the BI-RADS category corresponded with a rise in the malignancy rate (p= 0.004). Conclusion: The BI-RADS lexicon and final assessment of breast US reliably detect and characterize malignancy in mammographically negative patients with pathologic nipple discharge.

Original languageEnglish
Pages (from-to)308-315
Number of pages8
JournalJournal of Breast Cancer
Volume19
Issue number3
DOIs
Publication statusPublished - 2016 Sep

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Information Systems
Ultrasonography
Breast
Neoplasms
Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Papillary Carcinoma
Nipple Discharge
Biopsy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{80b1fd9b245648fb9c0c5a690b171ade,
title = "Reliability of breast ultrasound BI-RADS final assessment in mammographically negative patients with nipple discharge and radiologic predictors of malignancy",
abstract = "Purpose: The purpose of this study was to retrospectively investigate the reliability of breast ultrasound (US) Breast Imaging Reporting and Data System (BI-RADS) final assessment in mammographically negative patients with pathologic nipple discharge, and to determine the clinical and ultrasonographic variables associated with malignancy in this group of patients. Methods: A total of 65 patients with 67 mammographically negative breast lesions that were pathologically confirmed through US-guided biopsy were included. Results: Of the 53 BI-RADS category 4 and 5 lesions, eight (15.1{\%}) were malignant (six ductal carcinomas in situ, one invasive ductal carcinoma, and one solid papillary carcinoma). There was no malignancy among the remaining 14 category 3 lesions. Malignant lesions more frequently displayed a round or irregular shape (75.0{\%}, 6/8; p= 0.030) and nonparallel orientation (33.3{\%}, 4/12; p= 0.029) compared to the benign lesions. The increase in the BI-RADS category corresponded with a rise in the malignancy rate (p= 0.004). Conclusion: The BI-RADS lexicon and final assessment of breast US reliably detect and characterize malignancy in mammographically negative patients with pathologic nipple discharge.",
author = "Park, {Chae Jung} and Kim, {Eun Kyung} and Moon, {Hee Jung} and Yoon, {Jung Hyun} and Kim, {Min Jung}",
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Reliability of breast ultrasound BI-RADS final assessment in mammographically negative patients with nipple discharge and radiologic predictors of malignancy. / Park, Chae Jung; Kim, Eun Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Kim, Min Jung.

In: Journal of Breast Cancer, Vol. 19, No. 3, 09.2016, p. 308-315.

Research output: Contribution to journalArticle

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AB - Purpose: The purpose of this study was to retrospectively investigate the reliability of breast ultrasound (US) Breast Imaging Reporting and Data System (BI-RADS) final assessment in mammographically negative patients with pathologic nipple discharge, and to determine the clinical and ultrasonographic variables associated with malignancy in this group of patients. Methods: A total of 65 patients with 67 mammographically negative breast lesions that were pathologically confirmed through US-guided biopsy were included. Results: Of the 53 BI-RADS category 4 and 5 lesions, eight (15.1%) were malignant (six ductal carcinomas in situ, one invasive ductal carcinoma, and one solid papillary carcinoma). There was no malignancy among the remaining 14 category 3 lesions. Malignant lesions more frequently displayed a round or irregular shape (75.0%, 6/8; p= 0.030) and nonparallel orientation (33.3%, 4/12; p= 0.029) compared to the benign lesions. The increase in the BI-RADS category corresponded with a rise in the malignancy rate (p= 0.004). Conclusion: The BI-RADS lexicon and final assessment of breast US reliably detect and characterize malignancy in mammographically negative patients with pathologic nipple discharge.

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