Renal cell carcinoma in South Korea: A multicenter study

Haeryoung Kim, Nam Hoon Cho, Dong Sug Kim, Young Mi Kwon, Eun Kyung Kim, Seo Hee Rha, Yong Wook Park, Jung Weon Shim, Sang Sook Lee, Shi Nae Lee, Juhie Lee, Jin Sook Lee, Tae Jin Lee, Soo Jin Jung, Soon Hee Jung, Jin Haeng Chung, Hyun Yee Cho, Hee Jae Joo, Yeong Jin Choi, Chan ChoiWoon Sup Han, Bang Hur, Jae Y. Ro

Research output: Contribution to journalArticle

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Abstract

The incidence of renal cell carcinoma (RCC) in South Korea is steadily becoming similar to that in Western countries. This study summarizes the results of a 3-year multicenter survey of RCC in South Korea, conducted by the Korean Genitourinary Pathology Study Group. A total of 795 cases of RCC were collected from 20 institutes between 1995 and 1997, including 686 clear cell RCCs (86.3%), 58 papillary RCCS (7.30%), 49 chromphobe RCCs (6.16%), and 2 collecting duct RCCs (0.25%). At least 5 years of follow-up was available for 627 clear cell, 54 papillary, and 49 chromophobe RCCs. All subtypes presented most frequently with stage T3aN0M0 at the time of operation, and papillary RCCs demonstrated more frequent lymph node metastasis. Overall survival was not significantly related to the histological subtype (clear cell vs papillary, P = 0.8651; clear cell vs chromophobe, P = 0.0584; papillary vs chromophobe, P = 0.0743). For clear cell RCCs, statistically significant associations were found between overall survival and sex (P = 0.0153), multiplicity (P = 0.0461), necrosis (P = 0.0191), age, sarcomatoid change, TNM stage, nuclear grade, and modality of treatment (all P <0.0001). Overall survival was significantly associated with tumor size (P = 0.0307), nuclear grade (P = 0.0235), multiplicity, sarcomatoid change, and TNM stage (all P <0.0001) for papillary RCCs and with the presence of sarcomatoid change (P = 0.0281), nuclear grade (P = 0.0015), treatment modality (P = 0.0328), and TNM stage (P <0.0001) for chromophobe RCCs. Age (P = 0.0125), nodal stage (P = 0.0010), and treatment modality (P = 0.0001) were significant independent prognostic indicators for clear cell RCC on multivariate analysis. This is the first multicenter study of RCC in South Korea, demonstrating the general patterns and prognostic factors of Korean RCCs.

Original languageEnglish
Pages (from-to)1556-1563
Number of pages8
JournalHuman Pathology
Volume35
Issue number12
DOIs
Publication statusPublished - 2004 Dec

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Republic of Korea
Renal Cell Carcinoma
Multicenter Studies
Necrosis
Multivariate Analysis
Lymph Nodes
Pathology
Neoplasm Metastasis
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kim, H., Cho, N. H., Kim, D. S., Kwon, Y. M., Kim, E. K., Rha, S. H., ... Ro, J. Y. (2004). Renal cell carcinoma in South Korea: A multicenter study. Human Pathology, 35(12), 1556-1563. https://doi.org/10.1016/j.humpath.2004.06.011
Kim, Haeryoung ; Cho, Nam Hoon ; Kim, Dong Sug ; Kwon, Young Mi ; Kim, Eun Kyung ; Rha, Seo Hee ; Park, Yong Wook ; Shim, Jung Weon ; Lee, Sang Sook ; Lee, Shi Nae ; Lee, Juhie ; Lee, Jin Sook ; Lee, Tae Jin ; Jung, Soo Jin ; Jung, Soon Hee ; Chung, Jin Haeng ; Cho, Hyun Yee ; Joo, Hee Jae ; Choi, Yeong Jin ; Choi, Chan ; Han, Woon Sup ; Hur, Bang ; Ro, Jae Y. / Renal cell carcinoma in South Korea : A multicenter study. In: Human Pathology. 2004 ; Vol. 35, No. 12. pp. 1556-1563.
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abstract = "The incidence of renal cell carcinoma (RCC) in South Korea is steadily becoming similar to that in Western countries. This study summarizes the results of a 3-year multicenter survey of RCC in South Korea, conducted by the Korean Genitourinary Pathology Study Group. A total of 795 cases of RCC were collected from 20 institutes between 1995 and 1997, including 686 clear cell RCCs (86.3{\%}), 58 papillary RCCS (7.30{\%}), 49 chromphobe RCCs (6.16{\%}), and 2 collecting duct RCCs (0.25{\%}). At least 5 years of follow-up was available for 627 clear cell, 54 papillary, and 49 chromophobe RCCs. All subtypes presented most frequently with stage T3aN0M0 at the time of operation, and papillary RCCs demonstrated more frequent lymph node metastasis. Overall survival was not significantly related to the histological subtype (clear cell vs papillary, P = 0.8651; clear cell vs chromophobe, P = 0.0584; papillary vs chromophobe, P = 0.0743). For clear cell RCCs, statistically significant associations were found between overall survival and sex (P = 0.0153), multiplicity (P = 0.0461), necrosis (P = 0.0191), age, sarcomatoid change, TNM stage, nuclear grade, and modality of treatment (all P <0.0001). Overall survival was significantly associated with tumor size (P = 0.0307), nuclear grade (P = 0.0235), multiplicity, sarcomatoid change, and TNM stage (all P <0.0001) for papillary RCCs and with the presence of sarcomatoid change (P = 0.0281), nuclear grade (P = 0.0015), treatment modality (P = 0.0328), and TNM stage (P <0.0001) for chromophobe RCCs. Age (P = 0.0125), nodal stage (P = 0.0010), and treatment modality (P = 0.0001) were significant independent prognostic indicators for clear cell RCC on multivariate analysis. This is the first multicenter study of RCC in South Korea, demonstrating the general patterns and prognostic factors of Korean RCCs.",
author = "Haeryoung Kim and Cho, {Nam Hoon} and Kim, {Dong Sug} and Kwon, {Young Mi} and Kim, {Eun Kyung} and Rha, {Seo Hee} and Park, {Yong Wook} and Shim, {Jung Weon} and Lee, {Sang Sook} and Lee, {Shi Nae} and Juhie Lee and Lee, {Jin Sook} and Lee, {Tae Jin} and Jung, {Soo Jin} and Jung, {Soon Hee} and Chung, {Jin Haeng} and Cho, {Hyun Yee} and Joo, {Hee Jae} and Choi, {Yeong Jin} and Chan Choi and Han, {Woon Sup} and Bang Hur and Ro, {Jae Y.}",
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Kim, H, Cho, NH, Kim, DS, Kwon, YM, Kim, EK, Rha, SH, Park, YW, Shim, JW, Lee, SS, Lee, SN, Lee, J, Lee, JS, Lee, TJ, Jung, SJ, Jung, SH, Chung, JH, Cho, HY, Joo, HJ, Choi, YJ, Choi, C, Han, WS, Hur, B & Ro, JY 2004, 'Renal cell carcinoma in South Korea: A multicenter study', Human Pathology, vol. 35, no. 12, pp. 1556-1563. https://doi.org/10.1016/j.humpath.2004.06.011

Renal cell carcinoma in South Korea : A multicenter study. / Kim, Haeryoung; Cho, Nam Hoon; Kim, Dong Sug; Kwon, Young Mi; Kim, Eun Kyung; Rha, Seo Hee; Park, Yong Wook; Shim, Jung Weon; Lee, Sang Sook; Lee, Shi Nae; Lee, Juhie; Lee, Jin Sook; Lee, Tae Jin; Jung, Soo Jin; Jung, Soon Hee; Chung, Jin Haeng; Cho, Hyun Yee; Joo, Hee Jae; Choi, Yeong Jin; Choi, Chan; Han, Woon Sup; Hur, Bang; Ro, Jae Y.

In: Human Pathology, Vol. 35, No. 12, 12.2004, p. 1556-1563.

Research output: Contribution to journalArticle

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T1 - Renal cell carcinoma in South Korea

T2 - A multicenter study

AU - Kim, Haeryoung

AU - Cho, Nam Hoon

AU - Kim, Dong Sug

AU - Kwon, Young Mi

AU - Kim, Eun Kyung

AU - Rha, Seo Hee

AU - Park, Yong Wook

AU - Shim, Jung Weon

AU - Lee, Sang Sook

AU - Lee, Shi Nae

AU - Lee, Juhie

AU - Lee, Jin Sook

AU - Lee, Tae Jin

AU - Jung, Soo Jin

AU - Jung, Soon Hee

AU - Chung, Jin Haeng

AU - Cho, Hyun Yee

AU - Joo, Hee Jae

AU - Choi, Yeong Jin

AU - Choi, Chan

AU - Han, Woon Sup

AU - Hur, Bang

AU - Ro, Jae Y.

PY - 2004/12

Y1 - 2004/12

N2 - The incidence of renal cell carcinoma (RCC) in South Korea is steadily becoming similar to that in Western countries. This study summarizes the results of a 3-year multicenter survey of RCC in South Korea, conducted by the Korean Genitourinary Pathology Study Group. A total of 795 cases of RCC were collected from 20 institutes between 1995 and 1997, including 686 clear cell RCCs (86.3%), 58 papillary RCCS (7.30%), 49 chromphobe RCCs (6.16%), and 2 collecting duct RCCs (0.25%). At least 5 years of follow-up was available for 627 clear cell, 54 papillary, and 49 chromophobe RCCs. All subtypes presented most frequently with stage T3aN0M0 at the time of operation, and papillary RCCs demonstrated more frequent lymph node metastasis. Overall survival was not significantly related to the histological subtype (clear cell vs papillary, P = 0.8651; clear cell vs chromophobe, P = 0.0584; papillary vs chromophobe, P = 0.0743). For clear cell RCCs, statistically significant associations were found between overall survival and sex (P = 0.0153), multiplicity (P = 0.0461), necrosis (P = 0.0191), age, sarcomatoid change, TNM stage, nuclear grade, and modality of treatment (all P <0.0001). Overall survival was significantly associated with tumor size (P = 0.0307), nuclear grade (P = 0.0235), multiplicity, sarcomatoid change, and TNM stage (all P <0.0001) for papillary RCCs and with the presence of sarcomatoid change (P = 0.0281), nuclear grade (P = 0.0015), treatment modality (P = 0.0328), and TNM stage (P <0.0001) for chromophobe RCCs. Age (P = 0.0125), nodal stage (P = 0.0010), and treatment modality (P = 0.0001) were significant independent prognostic indicators for clear cell RCC on multivariate analysis. This is the first multicenter study of RCC in South Korea, demonstrating the general patterns and prognostic factors of Korean RCCs.

AB - The incidence of renal cell carcinoma (RCC) in South Korea is steadily becoming similar to that in Western countries. This study summarizes the results of a 3-year multicenter survey of RCC in South Korea, conducted by the Korean Genitourinary Pathology Study Group. A total of 795 cases of RCC were collected from 20 institutes between 1995 and 1997, including 686 clear cell RCCs (86.3%), 58 papillary RCCS (7.30%), 49 chromphobe RCCs (6.16%), and 2 collecting duct RCCs (0.25%). At least 5 years of follow-up was available for 627 clear cell, 54 papillary, and 49 chromophobe RCCs. All subtypes presented most frequently with stage T3aN0M0 at the time of operation, and papillary RCCs demonstrated more frequent lymph node metastasis. Overall survival was not significantly related to the histological subtype (clear cell vs papillary, P = 0.8651; clear cell vs chromophobe, P = 0.0584; papillary vs chromophobe, P = 0.0743). For clear cell RCCs, statistically significant associations were found between overall survival and sex (P = 0.0153), multiplicity (P = 0.0461), necrosis (P = 0.0191), age, sarcomatoid change, TNM stage, nuclear grade, and modality of treatment (all P <0.0001). Overall survival was significantly associated with tumor size (P = 0.0307), nuclear grade (P = 0.0235), multiplicity, sarcomatoid change, and TNM stage (all P <0.0001) for papillary RCCs and with the presence of sarcomatoid change (P = 0.0281), nuclear grade (P = 0.0015), treatment modality (P = 0.0328), and TNM stage (P <0.0001) for chromophobe RCCs. Age (P = 0.0125), nodal stage (P = 0.0010), and treatment modality (P = 0.0001) were significant independent prognostic indicators for clear cell RCC on multivariate analysis. This is the first multicenter study of RCC in South Korea, demonstrating the general patterns and prognostic factors of Korean RCCs.

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