Abstract
Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Case 2 consisted of homogeneously delicate microvascular proliferations resembling a capillary hemangioma with scattered inconspicuous clear cells. The clear cells of Case 1 were PAX8(+), CK7(diffuse+), CA9(diffuse+, cup-shaped), and inhibin A(−). The hemangioblastoma-like areas were PAX8(+), CK7(−), CA9(diffuse+), and inhibin A(diffuse+). Case 2 showed PAX8(+), CK7(−), and CA9(diffuse+). They can be diagnostically challenging, and it is important to recognize that a pure hemangioma or hemangioblastoma of the kidneys is very rare, and that RCCs with clear cell morphology rarely exhibit hemangioma-like characteristics.
| Original language | English |
|---|---|
| Pages (from-to) | 631-638 |
| Number of pages | 8 |
| Journal | International Journal of Surgical Pathology |
| Volume | 27 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2019 Sep 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Anatomy
- Surgery
- Pathology and Forensic Medicine
Cite this
}
Renal Cell Carcinoma With Hemangioma-Like Features : Diagnostic Implications and Review of the Literature. / Kim, Eun Kyung; Jang, Mi; Choi, Yoon Jung; Cho, Nam Hoon.
In: International Journal of Surgical Pathology, Vol. 27, No. 6, 01.09.2019, p. 631-638.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Renal Cell Carcinoma With Hemangioma-Like Features
T2 - Diagnostic Implications and Review of the Literature
AU - Kim, Eun Kyung
AU - Jang, Mi
AU - Choi, Yoon Jung
AU - Cho, Nam Hoon
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Case 2 consisted of homogeneously delicate microvascular proliferations resembling a capillary hemangioma with scattered inconspicuous clear cells. The clear cells of Case 1 were PAX8(+), CK7(diffuse+), CA9(diffuse+, cup-shaped), and inhibin A(−). The hemangioblastoma-like areas were PAX8(+), CK7(−), CA9(diffuse+), and inhibin A(diffuse+). Case 2 showed PAX8(+), CK7(−), and CA9(diffuse+). They can be diagnostically challenging, and it is important to recognize that a pure hemangioma or hemangioblastoma of the kidneys is very rare, and that RCCs with clear cell morphology rarely exhibit hemangioma-like characteristics.
AB - Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Case 2 consisted of homogeneously delicate microvascular proliferations resembling a capillary hemangioma with scattered inconspicuous clear cells. The clear cells of Case 1 were PAX8(+), CK7(diffuse+), CA9(diffuse+, cup-shaped), and inhibin A(−). The hemangioblastoma-like areas were PAX8(+), CK7(−), CA9(diffuse+), and inhibin A(diffuse+). Case 2 showed PAX8(+), CK7(−), and CA9(diffuse+). They can be diagnostically challenging, and it is important to recognize that a pure hemangioma or hemangioblastoma of the kidneys is very rare, and that RCCs with clear cell morphology rarely exhibit hemangioma-like characteristics.
UR - http://www.scopus.com/inward/record.url?scp=85064177484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064177484&partnerID=8YFLogxK
U2 - 10.1177/1066896919840435
DO - 10.1177/1066896919840435
M3 - Review article
C2 - 30955392
AN - SCOPUS:85064177484
VL - 27
SP - 631
EP - 638
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
SN - 1066-8969
IS - 6
ER -