Renal Cell Carcinoma With Hemangioma-Like Features: Diagnostic Implications and Review of the Literature

Eun Kyung Kim, Mi Jang, Yoon Jung Choi, Nam Hoon Cho

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Case 2 consisted of homogeneously delicate microvascular proliferations resembling a capillary hemangioma with scattered inconspicuous clear cells. The clear cells of Case 1 were PAX8(+), CK7(diffuse+), CA9(diffuse+, cup-shaped), and inhibin A(−). The hemangioblastoma-like areas were PAX8(+), CK7(−), CA9(diffuse+), and inhibin A(diffuse+). Case 2 showed PAX8(+), CK7(−), and CA9(diffuse+). They can be diagnostically challenging, and it is important to recognize that a pure hemangioma or hemangioblastoma of the kidneys is very rare, and that RCCs with clear cell morphology rarely exhibit hemangioma-like characteristics.

Original languageEnglish
Pages (from-to)631-638
Number of pages8
JournalInternational Journal of Surgical Pathology
Volume27
Issue number6
DOIs
Publication statusPublished - 2019 Sep 1

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Hemangioblastoma
Hemangioma
Renal Cell Carcinoma
Capillary Hemangioma
Stromal Cells
Kidney
Growth
inhibin A

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

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title = "Renal Cell Carcinoma With Hemangioma-Like Features: Diagnostic Implications and Review of the Literature",
abstract = "Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Case 2 consisted of homogeneously delicate microvascular proliferations resembling a capillary hemangioma with scattered inconspicuous clear cells. The clear cells of Case 1 were PAX8(+), CK7(diffuse+), CA9(diffuse+, cup-shaped), and inhibin A(−). The hemangioblastoma-like areas were PAX8(+), CK7(−), CA9(diffuse+), and inhibin A(diffuse+). Case 2 showed PAX8(+), CK7(−), and CA9(diffuse+). They can be diagnostically challenging, and it is important to recognize that a pure hemangioma or hemangioblastoma of the kidneys is very rare, and that RCCs with clear cell morphology rarely exhibit hemangioma-like characteristics.",
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Renal Cell Carcinoma With Hemangioma-Like Features : Diagnostic Implications and Review of the Literature. / Kim, Eun Kyung; Jang, Mi; Choi, Yoon Jung; Cho, Nam Hoon.

In: International Journal of Surgical Pathology, Vol. 27, No. 6, 01.09.2019, p. 631-638.

Research output: Contribution to journalReview article

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