Renal manifestations in 2007 Korean patients with Behçet's disease

Sung Bin Cho, Jihyun Kim, Shin-Wook Kang, TaeHyun Yoo, Zhenlong Zheng, Suhyun Cho, Hye Sun Lee, Dongsik Bang

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Purpose: Behçet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. Materials and Methods: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. Results: Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. Conclusion: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalYonsei Medical Journal
Volume54
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Kidney
Blood Sedimentation
Proteinuria
Hematuria
Blood Vessels
Urinalysis
Immunoglobulin A
Ulcer
Medical Records
Multivariate Analysis
Logistic Models
Regression Analysis
Biopsy
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cho, Sung Bin ; Kim, Jihyun ; Kang, Shin-Wook ; Yoo, TaeHyun ; Zheng, Zhenlong ; Cho, Suhyun ; Lee, Hye Sun ; Bang, Dongsik. / Renal manifestations in 2007 Korean patients with Behçet's disease. In: Yonsei Medical Journal. 2013 ; Vol. 54, No. 1. pp. 189-196.
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abstract = "Purpose: Beh{\cc}et's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. Materials and Methods: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. Results: Among the 2007 BD patients, we noted hematuria in 412 (20.5{\%}) and proteinuria in 29 (1.4{\%}). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. Conclusion: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.",
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Renal manifestations in 2007 Korean patients with Behçet's disease. / Cho, Sung Bin; Kim, Jihyun; Kang, Shin-Wook; Yoo, TaeHyun; Zheng, Zhenlong; Cho, Suhyun; Lee, Hye Sun; Bang, Dongsik.

In: Yonsei Medical Journal, Vol. 54, No. 1, 01.01.2013, p. 189-196.

Research output: Contribution to journalReview article

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T1 - Renal manifestations in 2007 Korean patients with Behçet's disease

AU - Cho, Sung Bin

AU - Kim, Jihyun

AU - Kang, Shin-Wook

AU - Yoo, TaeHyun

AU - Zheng, Zhenlong

AU - Cho, Suhyun

AU - Lee, Hye Sun

AU - Bang, Dongsik

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N2 - Purpose: Behçet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. Materials and Methods: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. Results: Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. Conclusion: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.

AB - Purpose: Behçet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. Materials and Methods: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. Results: Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. Conclusion: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.

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