Renal outcome after kidney-transplantation in Korean patients with lupus nephritis

E. S. Park, S. S. Ahn, S. M. Jung, J. J. Song, Y. B. Park, S. W. Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated renal outcome of kidney-transplantation in 19 Korean recipients with biopsy-proven lupus nephritis and compared it with 18 Korean age- and gender-matched recipients without lupus nephritis who were diagnosed with end-stage renal disease caused by renal diseases other than lupus nephritis in a single centre. We reviewed histological findings of kidneys and calculated cumulative dose of immunosuppressive agents. We assessed renal flare of systemic lupus erythematosus, recurrence of lupus nephritis and graft failure as prognosis. The mean age of recipients with lupus nephritis was 43.5 years and all patients were female. Six patients had class III, 10 had class IV and three had class V. There were no meaningful differences in demographic data, renal replacement modality, cumulative doses of immunosuppressants and prognosis between recipients with and without lupus nephritis. Eight patients experienced renal flare of systemic lupus erythematosus, but there were no cases of recurrence of lupus nephritis or graft failure in recipients with lupus nephritis. Kidney-recipients with class IV lupus nephritis exhibited a lower cumulative renal flare of systemic lupus erythematosus free survival rate than those with class III lupus nephritis. In conclusion, renal outcome of kidney-transplantation in patients with lupus nephritis is similar to that in those without lupus nephritis, and class IV was associated with renal flare of systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalLupus
Volume27
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Lupus Nephritis
Kidney Transplantation
Kidney
Systemic Lupus Erythematosus
Immunosuppressive Agents
Transplants
Recurrence
Chronic Kidney Failure
Survival Rate

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Park, E. S. ; Ahn, S. S. ; Jung, S. M. ; Song, J. J. ; Park, Y. B. ; Lee, S. W. / Renal outcome after kidney-transplantation in Korean patients with lupus nephritis. In: Lupus. 2018 ; Vol. 27, No. 3. pp. 461-467.
@article{b9b6e03cfd4d4304a29e41b2f3e08de1,
title = "Renal outcome after kidney-transplantation in Korean patients with lupus nephritis",
abstract = "We investigated renal outcome of kidney-transplantation in 19 Korean recipients with biopsy-proven lupus nephritis and compared it with 18 Korean age- and gender-matched recipients without lupus nephritis who were diagnosed with end-stage renal disease caused by renal diseases other than lupus nephritis in a single centre. We reviewed histological findings of kidneys and calculated cumulative dose of immunosuppressive agents. We assessed renal flare of systemic lupus erythematosus, recurrence of lupus nephritis and graft failure as prognosis. The mean age of recipients with lupus nephritis was 43.5 years and all patients were female. Six patients had class III, 10 had class IV and three had class V. There were no meaningful differences in demographic data, renal replacement modality, cumulative doses of immunosuppressants and prognosis between recipients with and without lupus nephritis. Eight patients experienced renal flare of systemic lupus erythematosus, but there were no cases of recurrence of lupus nephritis or graft failure in recipients with lupus nephritis. Kidney-recipients with class IV lupus nephritis exhibited a lower cumulative renal flare of systemic lupus erythematosus free survival rate than those with class III lupus nephritis. In conclusion, renal outcome of kidney-transplantation in patients with lupus nephritis is similar to that in those without lupus nephritis, and class IV was associated with renal flare of systemic lupus erythematosus.",
author = "Park, {E. S.} and Ahn, {S. S.} and Jung, {S. M.} and Song, {J. J.} and Park, {Y. B.} and Lee, {S. W.}",
year = "2018",
month = "3",
day = "1",
doi = "10.1177/0961203317725591",
language = "English",
volume = "27",
pages = "461--467",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "3",

}

Renal outcome after kidney-transplantation in Korean patients with lupus nephritis. / Park, E. S.; Ahn, S. S.; Jung, S. M.; Song, J. J.; Park, Y. B.; Lee, S. W.

In: Lupus, Vol. 27, No. 3, 01.03.2018, p. 461-467.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Renal outcome after kidney-transplantation in Korean patients with lupus nephritis

AU - Park, E. S.

AU - Ahn, S. S.

AU - Jung, S. M.

AU - Song, J. J.

AU - Park, Y. B.

AU - Lee, S. W.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - We investigated renal outcome of kidney-transplantation in 19 Korean recipients with biopsy-proven lupus nephritis and compared it with 18 Korean age- and gender-matched recipients without lupus nephritis who were diagnosed with end-stage renal disease caused by renal diseases other than lupus nephritis in a single centre. We reviewed histological findings of kidneys and calculated cumulative dose of immunosuppressive agents. We assessed renal flare of systemic lupus erythematosus, recurrence of lupus nephritis and graft failure as prognosis. The mean age of recipients with lupus nephritis was 43.5 years and all patients were female. Six patients had class III, 10 had class IV and three had class V. There were no meaningful differences in demographic data, renal replacement modality, cumulative doses of immunosuppressants and prognosis between recipients with and without lupus nephritis. Eight patients experienced renal flare of systemic lupus erythematosus, but there were no cases of recurrence of lupus nephritis or graft failure in recipients with lupus nephritis. Kidney-recipients with class IV lupus nephritis exhibited a lower cumulative renal flare of systemic lupus erythematosus free survival rate than those with class III lupus nephritis. In conclusion, renal outcome of kidney-transplantation in patients with lupus nephritis is similar to that in those without lupus nephritis, and class IV was associated with renal flare of systemic lupus erythematosus.

AB - We investigated renal outcome of kidney-transplantation in 19 Korean recipients with biopsy-proven lupus nephritis and compared it with 18 Korean age- and gender-matched recipients without lupus nephritis who were diagnosed with end-stage renal disease caused by renal diseases other than lupus nephritis in a single centre. We reviewed histological findings of kidneys and calculated cumulative dose of immunosuppressive agents. We assessed renal flare of systemic lupus erythematosus, recurrence of lupus nephritis and graft failure as prognosis. The mean age of recipients with lupus nephritis was 43.5 years and all patients were female. Six patients had class III, 10 had class IV and three had class V. There were no meaningful differences in demographic data, renal replacement modality, cumulative doses of immunosuppressants and prognosis between recipients with and without lupus nephritis. Eight patients experienced renal flare of systemic lupus erythematosus, but there were no cases of recurrence of lupus nephritis or graft failure in recipients with lupus nephritis. Kidney-recipients with class IV lupus nephritis exhibited a lower cumulative renal flare of systemic lupus erythematosus free survival rate than those with class III lupus nephritis. In conclusion, renal outcome of kidney-transplantation in patients with lupus nephritis is similar to that in those without lupus nephritis, and class IV was associated with renal flare of systemic lupus erythematosus.

UR - http://www.scopus.com/inward/record.url?scp=85042085241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042085241&partnerID=8YFLogxK

U2 - 10.1177/0961203317725591

DO - 10.1177/0961203317725591

M3 - Article

C2 - 28799839

AN - SCOPUS:85042085241

VL - 27

SP - 461

EP - 467

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 3

ER -