Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis

Eun Seong Park, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, YongBeom Park, Sang Won Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives. We investigated renal outcome of kidney-transplantation in Korean recipients with biopsy-proven renal involvement of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a single centre. Methods. We reviewed the medical records of 144 Korean patients and included 3 female patients with microscopic polyangiitis (MPA) and one male patient with eosinophilic granulomatosis with polyangiitis (EGPA) in this study. We obtained clinical and laboratory data related to kidney-transplantation, analysed renal outcome of kidney-transplantation in 4 recipients with AAV and compared it with those of previous studies. Results. The mean age at diagnosis was 37.8 years and that at kidney-transplantation was 40.8 years. Time-gap from AAV to ESRD ranged from 1 to 48 months and that from AAV to kidney-transplantation ranged from 2 to 95 months. All kidney-recipients with had been followed-up for two years or greater. At diagnosis, MPO-ANCA was detected in only MPA patients, while, at transplantation, MPA-ANCA was detected in 2 MPA patients and an EGPA patient. All patients have received tacrolimus and mycophenolate mofetil based on glucocorticoid after kidney-transplantation. Among 4 kidney-recipients with AAV, one MPA patient underwent renal re-biopsies three times due to renal function deterioration during the follow-up. Renal histology revealed T cell-mediated and antibody-mediated rejection rather than relapse of MPA. Neither relapse nor graft failure was observed in our study. Conclusion. Renal outcome of kidney-transplantation in recipients with AAV was good and kidney-transplantation is deserved to be recommend as a safe and effective therapeutic modality to AAV patients with ESRD.

Original languageEnglish
Pages (from-to)S115-S120
JournalClinical and Experimental Rheumatology
Volume36
Publication statusPublished - 2018 Jan 1

Fingerprint

Antineutrophil Cytoplasmic Antibodies
Vasculitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Microscopic Polyangiitis
Kidney Transplantation
Kidney
Granulomatosis with Polyangiitis
Chronic Kidney Failure
Mycophenolic Acid
Biopsy
Recurrence
Tacrolimus
Glucocorticoids
Medical Records
Histology
Transplantation
T-Lymphocytes
Transplants
Antibodies

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Park, Eun Seong ; Ahn, Sung Soo ; Jung, Seung Min ; Song, Jason Jungsik ; Park, YongBeom ; Lee, Sang Won. / Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis. In: Clinical and Experimental Rheumatology. 2018 ; Vol. 36. pp. S115-S120.
@article{a8586ab917fa46fd8b70960cbb1d9b81,
title = "Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis",
abstract = "Objectives. We investigated renal outcome of kidney-transplantation in Korean recipients with biopsy-proven renal involvement of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a single centre. Methods. We reviewed the medical records of 144 Korean patients and included 3 female patients with microscopic polyangiitis (MPA) and one male patient with eosinophilic granulomatosis with polyangiitis (EGPA) in this study. We obtained clinical and laboratory data related to kidney-transplantation, analysed renal outcome of kidney-transplantation in 4 recipients with AAV and compared it with those of previous studies. Results. The mean age at diagnosis was 37.8 years and that at kidney-transplantation was 40.8 years. Time-gap from AAV to ESRD ranged from 1 to 48 months and that from AAV to kidney-transplantation ranged from 2 to 95 months. All kidney-recipients with had been followed-up for two years or greater. At diagnosis, MPO-ANCA was detected in only MPA patients, while, at transplantation, MPA-ANCA was detected in 2 MPA patients and an EGPA patient. All patients have received tacrolimus and mycophenolate mofetil based on glucocorticoid after kidney-transplantation. Among 4 kidney-recipients with AAV, one MPA patient underwent renal re-biopsies three times due to renal function deterioration during the follow-up. Renal histology revealed T cell-mediated and antibody-mediated rejection rather than relapse of MPA. Neither relapse nor graft failure was observed in our study. Conclusion. Renal outcome of kidney-transplantation in recipients with AAV was good and kidney-transplantation is deserved to be recommend as a safe and effective therapeutic modality to AAV patients with ESRD.",
author = "Park, {Eun Seong} and Ahn, {Sung Soo} and Jung, {Seung Min} and Song, {Jason Jungsik} and YongBeom Park and Lee, {Sang Won}",
year = "2018",
month = "1",
day = "1",
language = "English",
volume = "36",
pages = "S115--S120",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",

}

Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis. / Park, Eun Seong; Ahn, Sung Soo; Jung, Seung Min; Song, Jason Jungsik; Park, YongBeom; Lee, Sang Won.

In: Clinical and Experimental Rheumatology, Vol. 36, 01.01.2018, p. S115-S120.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Renal outcome of kidney-transplantation in Korean recipients with ANCA-associated vasculitis

AU - Park, Eun Seong

AU - Ahn, Sung Soo

AU - Jung, Seung Min

AU - Song, Jason Jungsik

AU - Park, YongBeom

AU - Lee, Sang Won

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives. We investigated renal outcome of kidney-transplantation in Korean recipients with biopsy-proven renal involvement of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a single centre. Methods. We reviewed the medical records of 144 Korean patients and included 3 female patients with microscopic polyangiitis (MPA) and one male patient with eosinophilic granulomatosis with polyangiitis (EGPA) in this study. We obtained clinical and laboratory data related to kidney-transplantation, analysed renal outcome of kidney-transplantation in 4 recipients with AAV and compared it with those of previous studies. Results. The mean age at diagnosis was 37.8 years and that at kidney-transplantation was 40.8 years. Time-gap from AAV to ESRD ranged from 1 to 48 months and that from AAV to kidney-transplantation ranged from 2 to 95 months. All kidney-recipients with had been followed-up for two years or greater. At diagnosis, MPO-ANCA was detected in only MPA patients, while, at transplantation, MPA-ANCA was detected in 2 MPA patients and an EGPA patient. All patients have received tacrolimus and mycophenolate mofetil based on glucocorticoid after kidney-transplantation. Among 4 kidney-recipients with AAV, one MPA patient underwent renal re-biopsies three times due to renal function deterioration during the follow-up. Renal histology revealed T cell-mediated and antibody-mediated rejection rather than relapse of MPA. Neither relapse nor graft failure was observed in our study. Conclusion. Renal outcome of kidney-transplantation in recipients with AAV was good and kidney-transplantation is deserved to be recommend as a safe and effective therapeutic modality to AAV patients with ESRD.

AB - Objectives. We investigated renal outcome of kidney-transplantation in Korean recipients with biopsy-proven renal involvement of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a single centre. Methods. We reviewed the medical records of 144 Korean patients and included 3 female patients with microscopic polyangiitis (MPA) and one male patient with eosinophilic granulomatosis with polyangiitis (EGPA) in this study. We obtained clinical and laboratory data related to kidney-transplantation, analysed renal outcome of kidney-transplantation in 4 recipients with AAV and compared it with those of previous studies. Results. The mean age at diagnosis was 37.8 years and that at kidney-transplantation was 40.8 years. Time-gap from AAV to ESRD ranged from 1 to 48 months and that from AAV to kidney-transplantation ranged from 2 to 95 months. All kidney-recipients with had been followed-up for two years or greater. At diagnosis, MPO-ANCA was detected in only MPA patients, while, at transplantation, MPA-ANCA was detected in 2 MPA patients and an EGPA patient. All patients have received tacrolimus and mycophenolate mofetil based on glucocorticoid after kidney-transplantation. Among 4 kidney-recipients with AAV, one MPA patient underwent renal re-biopsies three times due to renal function deterioration during the follow-up. Renal histology revealed T cell-mediated and antibody-mediated rejection rather than relapse of MPA. Neither relapse nor graft failure was observed in our study. Conclusion. Renal outcome of kidney-transplantation in recipients with AAV was good and kidney-transplantation is deserved to be recommend as a safe and effective therapeutic modality to AAV patients with ESRD.

UR - http://www.scopus.com/inward/record.url?scp=85050724695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050724695&partnerID=8YFLogxK

M3 - Article

C2 - 29185962

AN - SCOPUS:85050724695

VL - 36

SP - S115-S120

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

ER -