Renal tissue elasticity by acoustic radiation force impulse: A prospective study of healthy kidney donors

Alan Lee, Dong Jin Joo, Woong Kyu Han, Hyeon Joo Jeong, Min Jung Oh, Yu Seun Kim, Young Taik Oh

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Some studies reported the correlations between renal parenchymal stiffness measured by transient elastography or acoustic radiation force impulse (ARFI) and the extent of interstitial fibrosis. This study was prospectively designed to evaluate the correlation between clinical, histological findings and the kidney shear wave velocity (SWV, m/s) assessed by ARFI elastography to identify factors affecting the kidney SWV in normal patients. METHODS: Seventy-three adult living kidney transplantation donors were enrolled in our center between September 2010 and January 2013. Before transplantation, all donors were evaluated by ARFI elastography to identify the range of SWV in kidneys. Time-zero biopsies were performed on all graft kidneys before implantation. RESULTS: Mean age of donors was 42.0 ± 11.3 years. The mean SWV and depth were 2.21 ± 0.58 m/s and 5.37 ± 1.06 cm. All histological findings showed mild degree of the Banff score, only grade I. In univariate analyses, the SWV was not associated with all histological parameters. Age (r = -0.274, P = .019) diastolic blood pressure (DBP, r = -0.255, P = .030) and depth for SWV measurement (r = -0.345, P = .003) were significantly correlated with the SWV. In multivariate linear regression analysis, age, gender, body mass index (BMI), and depth for SWV measurement were significantly correlated with the SWV (P = .003, .005, .002, and .004, respectively). CONCLUSIONS: We demonstrated that all histological findings are not correlated with the SWV of donor kidney. Otherwise, factors influencing the kidney SWV assessed by ARFI elastography are age, gender, BMI, and depth for the SWV measurement in donors for kidney transplantation.

Original languageEnglish
Pages (from-to)e23561
JournalMedicine
Volume100
Issue number3
DOIs
Publication statusPublished - 2021 Jan 22

Bibliographical note

Publisher Copyright:
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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