Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells

Jiyeon Kim, Chang Seung Ha, Hae June Lee, Kiwon Song

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We investigated the effects of extremely low frequency time-varying magnetic fields (MFs) on human normal and cancer cells. Whereas a single exposure to a 60-Hz time-varying MF of 6. mT for 30. min showed no effect, repetitive exposure decreased cell viability. This decrease was accompanied by phosphorylation of γ-H2AX, a common DNA double-strand break (DSB) marker, and checkpoint kinase 2 (Chk2), which is critical to the DNA damage checkpoint pathway. In addition, repetitive exposure to a time-varying MF of 6. mT for 30. min every 24. h for 3. days led to p38 activation and induction of apoptosis in cancer and normal cells. Therefore, these results demonstrate that repetitive exposure to MF with extremely low frequency can induce DNA DSBs and apoptosis through p38 activation. These results also suggest the need for further evaluation of the effects of repetitive exposure to environmental time-varying MFs on human health.

Original languageEnglish
Pages (from-to)739-744
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume400
Issue number4
DOIs
Publication statusPublished - 2010 Oct 1

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Double-Stranded DNA Breaks
Magnetic Fields
Cells
Apoptosis
Magnetic fields
DNA
Checkpoint Kinase 2
Chemical activation
Phosphorylation
Environmental Exposure
DNA Damage
Neoplasms
Cell Survival
Health

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells. / Kim, Jiyeon; Ha, Chang Seung; Lee, Hae June; Song, Kiwon.

In: Biochemical and Biophysical Research Communications, Vol. 400, No. 4, 01.10.2010, p. 739-744.

Research output: Contribution to journalArticle

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