Repolarization heterogeneity of magnetocardiography predicts long-term prognosis in patients with acute myocardial infarction

Woo Dae Bang, Kiwoong Kim, Yong Ho Lee, Hyukchan Kwon, Yongki Park, Hui Nam Pak, Young Guk Ko, Moonhyoung Lee, Boyoung Joung

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Abstract

Purpose: Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI. Meterials and Methods: In 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated. Results: MACE occurred in 31 (25%) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77% (24/31) and 54% (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and genderadjusted hazard ratios for MACE (hazard ratio 2.89, 95% confidence interval 1.20–6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02). Conclusion: Non-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.

Original languageEnglish
Pages (from-to)1339-1346
Number of pages8
JournalYonsei medical journal
Volume57
Issue number6
DOIs
Publication statusPublished - 2016 Nov

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Magnetocardiography
Myocardial Infarction
Infarction
Disease-Free Survival
Multivariate Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Bang, Woo Dae ; Kim, Kiwoong ; Lee, Yong Ho ; Kwon, Hyukchan ; Park, Yongki ; Pak, Hui Nam ; Ko, Young Guk ; Lee, Moonhyoung ; Joung, Boyoung. / Repolarization heterogeneity of magnetocardiography predicts long-term prognosis in patients with acute myocardial infarction. In: Yonsei medical journal. 2016 ; Vol. 57, No. 6. pp. 1339-1346.
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title = "Repolarization heterogeneity of magnetocardiography predicts long-term prognosis in patients with acute myocardial infarction",
abstract = "Purpose: Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI. Meterials and Methods: In 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated. Results: MACE occurred in 31 (25{\%}) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77{\%} (24/31) and 54{\%} (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and genderadjusted hazard ratios for MACE (hazard ratio 2.89, 95{\%} confidence interval 1.20–6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02). Conclusion: Non-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.",
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Repolarization heterogeneity of magnetocardiography predicts long-term prognosis in patients with acute myocardial infarction. / Bang, Woo Dae; Kim, Kiwoong; Lee, Yong Ho; Kwon, Hyukchan; Park, Yongki; Pak, Hui Nam; Ko, Young Guk; Lee, Moonhyoung; Joung, Boyoung.

In: Yonsei medical journal, Vol. 57, No. 6, 11.2016, p. 1339-1346.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Repolarization heterogeneity of magnetocardiography predicts long-term prognosis in patients with acute myocardial infarction

AU - Bang, Woo Dae

AU - Kim, Kiwoong

AU - Lee, Yong Ho

AU - Kwon, Hyukchan

AU - Park, Yongki

AU - Pak, Hui Nam

AU - Ko, Young Guk

AU - Lee, Moonhyoung

AU - Joung, Boyoung

PY - 2016/11

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N2 - Purpose: Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI. Meterials and Methods: In 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated. Results: MACE occurred in 31 (25%) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77% (24/31) and 54% (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and genderadjusted hazard ratios for MACE (hazard ratio 2.89, 95% confidence interval 1.20–6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02). Conclusion: Non-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.

AB - Purpose: Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI. Meterials and Methods: In 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated. Results: MACE occurred in 31 (25%) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77% (24/31) and 54% (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and genderadjusted hazard ratios for MACE (hazard ratio 2.89, 95% confidence interval 1.20–6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02). Conclusion: Non-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.

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