Report of a human autopsy case in maxillary sinuses augmented using a synthetic bone substitute: Micro-computed tomographic and histologic observations

Jung Seok Lee, Jae Kook Cha, Daniel S. Thoma, Ui Won Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: This study of a human autopsy case aimed to characterize the histologic and micro-computed tomographic results of maxillary sinus augmentation using a synthetic bone substitute and simultaneous implant placement at 6 years. Material and methods: This report is based on the whole-body donation of a 62-year-old male patient who died due to bladder cancer. Implants had been placed in conjunction with sinus augmentation using a mixture of biphasic calcium phosphate and autogenous bone into both maxillary sinuses 6 years prior to the body donation. The maxillary sinus areas containing implants were gently removed from the cadaver and scanned using high-resolution micro-computed tomography. Samples were sectioned, prepared for undecalcified histologic slides and stained with haematoxylin-eosin. Results: The augmented volume was observed up to the apex of the implants, which were successfully osseointegrated. Cross-sectional micro-computed tomographic views revealed that the bone-substitute particles were embedded in radiopaque-mineralized tissues showing a trabecular pattern around the implants. The histologic analysis revealed mature lamellar bone surrounding the remaining bone-substitute particles as well as well-organized bone marrow spaces in the augment bone area and around the dental implants. Conclusion: This human autopsy study histologically confirmed the presence of successful bone formation and long-term volume stability after sinus augmentation using biphasic calcium phosphate and simultaneous implant placement.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalClinical Oral Implants Research
Volume29
Issue number3
DOIs
Publication statusPublished - 2018 Mar

Fingerprint

Bone Substitutes
Maxillary Sinus
Autopsy
Bone and Bones
Dental Implants
Hematoxylin
Eosine Yellowish-(YS)
Cadaver
Urinary Bladder Neoplasms
Osteogenesis
Bone Marrow
Tomography
hydroxyapatite-beta tricalcium phosphate

All Science Journal Classification (ASJC) codes

  • Oral Surgery

Cite this

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title = "Report of a human autopsy case in maxillary sinuses augmented using a synthetic bone substitute: Micro-computed tomographic and histologic observations",
abstract = "Objective: This study of a human autopsy case aimed to characterize the histologic and micro-computed tomographic results of maxillary sinus augmentation using a synthetic bone substitute and simultaneous implant placement at 6 years. Material and methods: This report is based on the whole-body donation of a 62-year-old male patient who died due to bladder cancer. Implants had been placed in conjunction with sinus augmentation using a mixture of biphasic calcium phosphate and autogenous bone into both maxillary sinuses 6 years prior to the body donation. The maxillary sinus areas containing implants were gently removed from the cadaver and scanned using high-resolution micro-computed tomography. Samples were sectioned, prepared for undecalcified histologic slides and stained with haematoxylin-eosin. Results: The augmented volume was observed up to the apex of the implants, which were successfully osseointegrated. Cross-sectional micro-computed tomographic views revealed that the bone-substitute particles were embedded in radiopaque-mineralized tissues showing a trabecular pattern around the implants. The histologic analysis revealed mature lamellar bone surrounding the remaining bone-substitute particles as well as well-organized bone marrow spaces in the augment bone area and around the dental implants. Conclusion: This human autopsy study histologically confirmed the presence of successful bone formation and long-term volume stability after sinus augmentation using biphasic calcium phosphate and simultaneous implant placement.",
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Report of a human autopsy case in maxillary sinuses augmented using a synthetic bone substitute : Micro-computed tomographic and histologic observations. / Lee, Jung Seok; Cha, Jae Kook; Thoma, Daniel S.; Jung, Ui Won.

In: Clinical Oral Implants Research, Vol. 29, No. 3, 03.2018, p. 339-345.

Research output: Contribution to journalArticle

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