Reproducibility of European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in patients treated with sorafenib

Mi Young Jeon, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Hyub Han, Song Ee Baek, Hye Soo Kim, Seung Up Kim, Mi Suk Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background & Aims: The European Association for the Study of the Liver criteria and the modified Response Evaluation Criteria in Solid Tumors are used for assessing the treatment outcomes of hepatocellular carcinoma. We investigated the inter- and intra-observer reproducibility of the European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in patients with advanced hepatocellular carcinoma treated with sorafenib. Methods: A total of 99 patients with treatment-naive advanced hepatocellular carcinoma receiving sorafenib were included. The κ-values for the inter- and intra-observer agreement of the treatment response were calculated. Results: Inter-observer agreement for baseline tumour number was excellent, as reflected by the high κ-value. The κ-statistics showed “excellent” concordance between the 2 sets of measurements by observer A regarding the overall responses using the European Association for the Study of the Liver criteria (κ =.948, agreement rate = 84.8%) and modified Response Evaluation Criteria in Solid Tumors (κ =.944, agreement rate = 83.8%; all P <.001). In addition, high κ-values indicated concordance between the first sets of measurements by observers A and B (κ =.991 by the European Association for the Study of the Liver criteria and.988 by modified Response Evaluation Criteria in Solid Tumors, all P <.001). When agreements in radiological overall responses between the 2 sets of measurements by observer B and between the second sets of measurements by observers A and B were calculated, similar results regarding high κ-values (>.8) were obtained. Conclusions: The reproducibility of the European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in assessing treatment outcomes was high in patients with advanced hepatocellular carcinoma treated with sorafenib.

Original languageEnglish
Pages (from-to)1655-1663
Number of pages9
JournalLiver International
Volume38
Issue number9
DOIs
Publication statusPublished - 2018 Sep

All Science Journal Classification (ASJC) codes

  • Hepatology

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