Reproductive and hormonal factors associated with fatty or dense breast patterns among Korean women

Jei Hun Jeon, Jung Hyun Kang, Yeonju Kim, Hoo Yeon Lee, Kui Son Choi, Jae Kwan Jun, Dong Kwan Oh, Chang Yoon Lee, Kyungran Ko, Euncheol Park

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Dense breasts have been suggested as a risk factor for breast cancer, but controversy still remains. This study evaluates the association of reproductive and hormonal factors with dense breasts among Korean women. Materials and Methods: Using a cross-sectional design, 516 women were recruited and classified for breast density patterns as being either fatty or dense, using the Breast Imaging Reporting and Data System (BI-RADS) of the American College of Radiology. Univariate and multivariate logistic regression models were used for statistical analysis. Results: In univariate logistic regression, older age, higher body mass index, older age at menarche, and oral contraceptive use were associated with more fatty breasts. On the contrary, longer duration of education, alcohol consumption, lower parity, menopause and use of hormone replacement therapy were associated with dense breasts. After adjustment, age and body mass index were inversely associated with breast density (p-value for trend <0.01, respectively), whereas nulliparous and premenopausal status were positively associated. Compared to women who had ≥2 children, nulliparous women had an 11.8-fold increase of dense breasts (p-value for trend <0.01). Compared to postmenopausal women, premenopausal women had 2.4-fold increase of dense breasts (odds ratio, 2.42; 95% confidence interval, 1.36 to 4.32). Conclusion: Young age, lower body mass index, lower parity, and premenopausal status were significantly associated with dense breasts in Korea.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalCancer Research and Treatment
Volume43
Issue number1
DOIs
Publication statusPublished - 2011 Mar 1

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Breast
Body Mass Index
Logistic Models
Parity
Social Adjustment
Menarche
Hormone Replacement Therapy
Korea
Oral Contraceptives
Menopause
Radiology
Information Systems
Alcohol Drinking
Odds Ratio
Confidence Intervals
Breast Neoplasms
Education

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Jeon, Jei Hun ; Kang, Jung Hyun ; Kim, Yeonju ; Lee, Hoo Yeon ; Choi, Kui Son ; Jun, Jae Kwan ; Oh, Dong Kwan ; Lee, Chang Yoon ; Ko, Kyungran ; Park, Euncheol. / Reproductive and hormonal factors associated with fatty or dense breast patterns among Korean women. In: Cancer Research and Treatment. 2011 ; Vol. 43, No. 1. pp. 42-48.
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abstract = "Purpose: Dense breasts have been suggested as a risk factor for breast cancer, but controversy still remains. This study evaluates the association of reproductive and hormonal factors with dense breasts among Korean women. Materials and Methods: Using a cross-sectional design, 516 women were recruited and classified for breast density patterns as being either fatty or dense, using the Breast Imaging Reporting and Data System (BI-RADS) of the American College of Radiology. Univariate and multivariate logistic regression models were used for statistical analysis. Results: In univariate logistic regression, older age, higher body mass index, older age at menarche, and oral contraceptive use were associated with more fatty breasts. On the contrary, longer duration of education, alcohol consumption, lower parity, menopause and use of hormone replacement therapy were associated with dense breasts. After adjustment, age and body mass index were inversely associated with breast density (p-value for trend <0.01, respectively), whereas nulliparous and premenopausal status were positively associated. Compared to women who had ≥2 children, nulliparous women had an 11.8-fold increase of dense breasts (p-value for trend <0.01). Compared to postmenopausal women, premenopausal women had 2.4-fold increase of dense breasts (odds ratio, 2.42; 95{\%} confidence interval, 1.36 to 4.32). Conclusion: Young age, lower body mass index, lower parity, and premenopausal status were significantly associated with dense breasts in Korea.",
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Reproductive and hormonal factors associated with fatty or dense breast patterns among Korean women. / Jeon, Jei Hun; Kang, Jung Hyun; Kim, Yeonju; Lee, Hoo Yeon; Choi, Kui Son; Jun, Jae Kwan; Oh, Dong Kwan; Lee, Chang Yoon; Ko, Kyungran; Park, Euncheol.

In: Cancer Research and Treatment, Vol. 43, No. 1, 01.03.2011, p. 42-48.

Research output: Contribution to journalArticle

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AU - Jun, Jae Kwan

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N2 - Purpose: Dense breasts have been suggested as a risk factor for breast cancer, but controversy still remains. This study evaluates the association of reproductive and hormonal factors with dense breasts among Korean women. Materials and Methods: Using a cross-sectional design, 516 women were recruited and classified for breast density patterns as being either fatty or dense, using the Breast Imaging Reporting and Data System (BI-RADS) of the American College of Radiology. Univariate and multivariate logistic regression models were used for statistical analysis. Results: In univariate logistic regression, older age, higher body mass index, older age at menarche, and oral contraceptive use were associated with more fatty breasts. On the contrary, longer duration of education, alcohol consumption, lower parity, menopause and use of hormone replacement therapy were associated with dense breasts. After adjustment, age and body mass index were inversely associated with breast density (p-value for trend <0.01, respectively), whereas nulliparous and premenopausal status were positively associated. Compared to women who had ≥2 children, nulliparous women had an 11.8-fold increase of dense breasts (p-value for trend <0.01). Compared to postmenopausal women, premenopausal women had 2.4-fold increase of dense breasts (odds ratio, 2.42; 95% confidence interval, 1.36 to 4.32). Conclusion: Young age, lower body mass index, lower parity, and premenopausal status were significantly associated with dense breasts in Korea.

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