Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila

Kwang Min Choe, Thomas Werner, Svenja Stöven, Dan Hultmark, Kathryn V. Anderson

Research output: Contribution to journalArticle

425 Citations (Scopus)

Abstract

Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-κB family transcription factor Relish.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalScience
Volume296
Issue number5566
DOIs
Publication statusPublished - 2002 Apr 12

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Innate Immunity
Drosophila
Peptidoglycan
Infection
Gram-Negative Bacteria
Cell Wall
Lipopolysaccharides
Transcription Factors
Peptides
Genes
peptidoglycan recognition protein

All Science Journal Classification (ASJC) codes

  • General

Cite this

Choe, Kwang Min ; Werner, Thomas ; Stöven, Svenja ; Hultmark, Dan ; Anderson, Kathryn V. / Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila. In: Science. 2002 ; Vol. 296, No. 5566. pp. 359-362.
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Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila. / Choe, Kwang Min; Werner, Thomas; Stöven, Svenja; Hultmark, Dan; Anderson, Kathryn V.

In: Science, Vol. 296, No. 5566, 12.04.2002, p. 359-362.

Research output: Contribution to journalArticle

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