Requirement of Runx3 in pulmonary vasculogenesis

Jong Min Lee, Hyuk Jae Kwon, Wing Fu Lai, Hansung Jung

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Runx3 is essential for normal vertebrate lung development and Runx3 knockout (KO) mice die within 24 h after birth because of various organ defects including defects in alveolar expansion. For proper early lung development, vasculogenesis and angiogenesis are necessary in humans. Previous studies have reported that various signaling molecules, such as CD31, VEGF and vWF, are closely related to lung vasculogenesis and angiogenesis. To confirm the relationship between Runx3-related lung defects and vasculogenesis, the localization of various blood vessel markers is examined in WT and Runx3 KO mouse lungs at PN1. Our results indicate that CD31, VEGF and vWF were dramatically up-regulated by a loss of Runx3 during lung development. Moreover, U0126, a MEK inhibitor, rescued the lung phenotype and vascularization by regulation of ERK signaling. Therefore, it was concluded that lung vasculogenesis and angiogenesis were induced in the Runx3 KO mouse, which shows lung defects, by increased CD31, VEGF and vWF.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalCell and Tissue Research
Volume356
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Lung
Knockout Mice
Vascular Endothelial Growth Factor A
Mitogen-Activated Protein Kinase Kinases
Blood Vessels
Vertebrates
Parturition
Phenotype

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Lee, Jong Min ; Kwon, Hyuk Jae ; Lai, Wing Fu ; Jung, Hansung. / Requirement of Runx3 in pulmonary vasculogenesis. In: Cell and Tissue Research. 2014 ; Vol. 356, No. 2. pp. 445-449.
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Requirement of Runx3 in pulmonary vasculogenesis. / Lee, Jong Min; Kwon, Hyuk Jae; Lai, Wing Fu; Jung, Hansung.

In: Cell and Tissue Research, Vol. 356, No. 2, 01.01.2014, p. 445-449.

Research output: Contribution to journalArticle

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