Research progress on detachable microneedles for advanced applications

Seung Hyun Park, Kang Ju Lee, Won Hyoung Ryu

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Microneedles (MNs) have undergone great advances in transdermal drug delivery, and commercialized MN applications are currently available in vaccination and cosmetic products. Despite the development of MN technologies, common limitations of MN products still exist. Typical MN patches are applied to target tissues, where the substrate of an MN patch must remain until the drug is delivered, which reduces patients’ compliance and hinders the applicability of the MN technique to many diseases in various tissues. MN research is ongoing to solve this issue. Areas covered: Most recent MNs developed by combining various biomaterials with appropriate fabrication processes are detachable MNs (DeMNs). Because of advances in biomaterials and fabrication techniques, various DeMNs have been rapidly developed. In this review, we discuss four types of DeMN: substrate-separable, multi-layered, crack-inducing, and shell DeMN. These DeMNs deliver various therapeutic agents ranging from small- and large-molecular-weight drugs to proteins and even stem cells for regeneration therapy. Furthermore, DeMNs are applied to skin as well as non-transdermal tissues. Expert opinion: It has become increasingly evident that novel MN technologies can be expected in terms of designs, fabrication methods, materials, and even possible application sites given the recent advances in DeMNs.

Original languageEnglish
Pages (from-to)1115-1131
Number of pages17
JournalExpert Opinion on Drug Delivery
Volume19
Issue number9
DOIs
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This work was supported by Global Infrastructure Program through the National Research Foundation of Korea (NRF) funded by the Korea government(MSIT)(2019K1A3A1A18116048)(WonHyoung Ryu), the NRF grant funded by the Korea government(MSIT)(2020R1A2C3013158)(WonHyoung Ryu), the Yonsei-KIST Convergence Research Program(WonHyoung Ryu), and a grant of NRF grant funded by the Korean government(MSIT)(2021R1F1A105502211)(KangJu Lee).

Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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