Residential greenness and blood lipids in urban-dwelling adults: The 33 Communities Chinese Health Study

Bo Yi Yang, Iana Markevych, Joachim Heinrich, Michael S. Bloom, Zhengmin Qian, Sarah Dee Geiger, Michael Vaughn, Shan Liu, Yuming Guo, Shyamali C. Dharmage, Bin Jalaludin, Luke D. Knibbs, Da Chen, Pasi Jalava, Shao Lin, Steve Hung-Lam Yim, Kang Kang Liu, Xiao Wen Zeng, Li Wen Hu, Guang Hui Dong

Research output: Contribution to journalArticle

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Abstract

While exposure to places with higher greenness shows health benefits, evidence is scarce on its lipidemic effects. We assessed the associations between residential greenness and blood lipids and effect mediations by air pollution, physical activity, and adiposity in China. Our study included 15,477 adults from the population-based 33 Communities Chinese Health Study, conducted between April and December 2009, in Northeastern China. We measured total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Residential greenness was estimated using two satellite-derived vegetation indices – the Normalized Difference Vegetation Index (NDVI) and the Soil Adjusted Vegetation Index (SAVI). We used both nitrogen dioxide (NO2) and particles ≤2.5 μm in aerodynamic diameter (PM2.5) as proxies of outdoor air pollution. Associations were assessed using linear mixed effects regression models and logistic mixed effects regression models, and mediation analyses were also performed. Living in higher greenness areas was consistently associated with lower TC, TG, and LDL-C levels and higher HDL-C levels (e.g., change in TC, TG, LDL-C, and HDL-C per 0.1-unit increase in NDVI500-m was −1.52%, −3.05%, −1.91%, and 0.52%, respectively). Similar results were obtained for the corresponding dyslipidemias. These associations were generally stronger in women and older adults. While educational levels showed effect modifications, the effect pattern was inconsistent. Both outdoor air pollution and body mass index mediated 9.1–62.3% and 5.6–40.1% of the associations for greenness and blood lipids, respectively, however, physical activity did not. Our results suggest beneficial associations between residing in places with higher greenness and blood lipid levels, especially in women and the elder individuals. The associations were partly mediated by lower air pollution and adiposity.

Original languageEnglish
Pages (from-to)14-22
Number of pages9
JournalEnvironmental Pollution
Volume250
DOIs
Publication statusPublished - 2019 Jul

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Cholesterol
Air Pollution
Air pollution
Lipids
Lipoproteins
Blood
Health
LDL Cholesterol
HDL Cholesterol
Triglycerides
Adiposity
China
Logistic Models
Exercise
Nitrogen Dioxide
Proxy
Insurance Benefits
Dyslipidemias
Logistics
Aerodynamics

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Yang, B. Y., Markevych, I., Heinrich, J., Bloom, M. S., Qian, Z., Geiger, S. D., ... Dong, G. H. (2019). Residential greenness and blood lipids in urban-dwelling adults: The 33 Communities Chinese Health Study. Environmental Pollution, 250, 14-22. https://doi.org/10.1016/j.envpol.2019.03.128
Yang, Bo Yi ; Markevych, Iana ; Heinrich, Joachim ; Bloom, Michael S. ; Qian, Zhengmin ; Geiger, Sarah Dee ; Vaughn, Michael ; Liu, Shan ; Guo, Yuming ; Dharmage, Shyamali C. ; Jalaludin, Bin ; Knibbs, Luke D. ; Chen, Da ; Jalava, Pasi ; Lin, Shao ; Hung-Lam Yim, Steve ; Liu, Kang Kang ; Zeng, Xiao Wen ; Hu, Li Wen ; Dong, Guang Hui. / Residential greenness and blood lipids in urban-dwelling adults : The 33 Communities Chinese Health Study. In: Environmental Pollution. 2019 ; Vol. 250. pp. 14-22.
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abstract = "While exposure to places with higher greenness shows health benefits, evidence is scarce on its lipidemic effects. We assessed the associations between residential greenness and blood lipids and effect mediations by air pollution, physical activity, and adiposity in China. Our study included 15,477 adults from the population-based 33 Communities Chinese Health Study, conducted between April and December 2009, in Northeastern China. We measured total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Residential greenness was estimated using two satellite-derived vegetation indices – the Normalized Difference Vegetation Index (NDVI) and the Soil Adjusted Vegetation Index (SAVI). We used both nitrogen dioxide (NO2) and particles ≤2.5 μm in aerodynamic diameter (PM2.5) as proxies of outdoor air pollution. Associations were assessed using linear mixed effects regression models and logistic mixed effects regression models, and mediation analyses were also performed. Living in higher greenness areas was consistently associated with lower TC, TG, and LDL-C levels and higher HDL-C levels (e.g., change in TC, TG, LDL-C, and HDL-C per 0.1-unit increase in NDVI500-m was −1.52{\%}, −3.05{\%}, −1.91{\%}, and 0.52{\%}, respectively). Similar results were obtained for the corresponding dyslipidemias. These associations were generally stronger in women and older adults. While educational levels showed effect modifications, the effect pattern was inconsistent. Both outdoor air pollution and body mass index mediated 9.1–62.3{\%} and 5.6–40.1{\%} of the associations for greenness and blood lipids, respectively, however, physical activity did not. Our results suggest beneficial associations between residing in places with higher greenness and blood lipid levels, especially in women and the elder individuals. The associations were partly mediated by lower air pollution and adiposity.",
author = "Yang, {Bo Yi} and Iana Markevych and Joachim Heinrich and Bloom, {Michael S.} and Zhengmin Qian and Geiger, {Sarah Dee} and Michael Vaughn and Shan Liu and Yuming Guo and Dharmage, {Shyamali C.} and Bin Jalaludin and Knibbs, {Luke D.} and Da Chen and Pasi Jalava and Shao Lin and {Hung-Lam Yim}, Steve and Liu, {Kang Kang} and Zeng, {Xiao Wen} and Hu, {Li Wen} and Dong, {Guang Hui}",
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Yang, BY, Markevych, I, Heinrich, J, Bloom, MS, Qian, Z, Geiger, SD, Vaughn, M, Liu, S, Guo, Y, Dharmage, SC, Jalaludin, B, Knibbs, LD, Chen, D, Jalava, P, Lin, S, Hung-Lam Yim, S, Liu, KK, Zeng, XW, Hu, LW & Dong, GH 2019, 'Residential greenness and blood lipids in urban-dwelling adults: The 33 Communities Chinese Health Study', Environmental Pollution, vol. 250, pp. 14-22. https://doi.org/10.1016/j.envpol.2019.03.128

Residential greenness and blood lipids in urban-dwelling adults : The 33 Communities Chinese Health Study. / Yang, Bo Yi; Markevych, Iana; Heinrich, Joachim; Bloom, Michael S.; Qian, Zhengmin; Geiger, Sarah Dee; Vaughn, Michael; Liu, Shan; Guo, Yuming; Dharmage, Shyamali C.; Jalaludin, Bin; Knibbs, Luke D.; Chen, Da; Jalava, Pasi; Lin, Shao; Hung-Lam Yim, Steve; Liu, Kang Kang; Zeng, Xiao Wen; Hu, Li Wen; Dong, Guang Hui.

In: Environmental Pollution, Vol. 250, 07.2019, p. 14-22.

Research output: Contribution to journalArticle

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T1 - Residential greenness and blood lipids in urban-dwelling adults

T2 - The 33 Communities Chinese Health Study

AU - Yang, Bo Yi

AU - Markevych, Iana

AU - Heinrich, Joachim

AU - Bloom, Michael S.

AU - Qian, Zhengmin

AU - Geiger, Sarah Dee

AU - Vaughn, Michael

AU - Liu, Shan

AU - Guo, Yuming

AU - Dharmage, Shyamali C.

AU - Jalaludin, Bin

AU - Knibbs, Luke D.

AU - Chen, Da

AU - Jalava, Pasi

AU - Lin, Shao

AU - Hung-Lam Yim, Steve

AU - Liu, Kang Kang

AU - Zeng, Xiao Wen

AU - Hu, Li Wen

AU - Dong, Guang Hui

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N2 - While exposure to places with higher greenness shows health benefits, evidence is scarce on its lipidemic effects. We assessed the associations between residential greenness and blood lipids and effect mediations by air pollution, physical activity, and adiposity in China. Our study included 15,477 adults from the population-based 33 Communities Chinese Health Study, conducted between April and December 2009, in Northeastern China. We measured total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Residential greenness was estimated using two satellite-derived vegetation indices – the Normalized Difference Vegetation Index (NDVI) and the Soil Adjusted Vegetation Index (SAVI). We used both nitrogen dioxide (NO2) and particles ≤2.5 μm in aerodynamic diameter (PM2.5) as proxies of outdoor air pollution. Associations were assessed using linear mixed effects regression models and logistic mixed effects regression models, and mediation analyses were also performed. Living in higher greenness areas was consistently associated with lower TC, TG, and LDL-C levels and higher HDL-C levels (e.g., change in TC, TG, LDL-C, and HDL-C per 0.1-unit increase in NDVI500-m was −1.52%, −3.05%, −1.91%, and 0.52%, respectively). Similar results were obtained for the corresponding dyslipidemias. These associations were generally stronger in women and older adults. While educational levels showed effect modifications, the effect pattern was inconsistent. Both outdoor air pollution and body mass index mediated 9.1–62.3% and 5.6–40.1% of the associations for greenness and blood lipids, respectively, however, physical activity did not. Our results suggest beneficial associations between residing in places with higher greenness and blood lipid levels, especially in women and the elder individuals. The associations were partly mediated by lower air pollution and adiposity.

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