Resolution of 2-silyloxy-1-oxiranyl-4-pentenes by HKR: Total synthesis of (5S,7R)-kurzilactone

Young Ju Kim, Jinsung Tae

Research output: Contribution to journalArticle

27 Citations (Scopus)


Enantiomerically pure syn- and anti-2-silyloxy-1-oxiranyl-4-pentenes were prepared by using Jacobsen's hydrolytic kinetic resolution (HKR) method. A resolved epoxypentenol generated in this fashion was used in the total synthesis of (5S,7R)-kurzilactone by a pathway employing epoxide ring-opening and RCM reactions in key steps.

Original languageEnglish
Article numberU27405ST
Pages (from-to)61-64
Number of pages4
Issue number1
Publication statusPublished - 2006 Jan 5


All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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