Response evaluation of giant-cell tumor of bone treated by denosumab

Histogram and texture analysis of CT images

Jisook Yi, Young Han Lee, Sang Kyum Kim, Seung Hyun Kim, Ho Taek Song, Kyoo Ho Shin, Jinsuck Suh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.

Original languageEnglish
Pages (from-to)570-577
Number of pages8
JournalJournal of Orthopaedic Science
Volume23
Issue number3
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Giant Cell Tumor of Bone
Tomography
Therapeutics
Denosumab
Neoplasms
Research Ethics Committees
Entropy
Osteoclasts
Giant Cells

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Yi, Jisook ; Lee, Young Han ; Kim, Sang Kyum ; Kim, Seung Hyun ; Song, Ho Taek ; Shin, Kyoo Ho ; Suh, Jinsuck. / Response evaluation of giant-cell tumor of bone treated by denosumab : Histogram and texture analysis of CT images. In: Journal of Orthopaedic Science. 2018 ; Vol. 23, No. 3. pp. 570-577.
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title = "Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images",
abstract = "Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.",
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Response evaluation of giant-cell tumor of bone treated by denosumab : Histogram and texture analysis of CT images. / Yi, Jisook; Lee, Young Han; Kim, Sang Kyum; Kim, Seung Hyun; Song, Ho Taek; Shin, Kyoo Ho; Suh, Jinsuck.

In: Journal of Orthopaedic Science, Vol. 23, No. 3, 01.05.2018, p. 570-577.

Research output: Contribution to journalArticle

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T1 - Response evaluation of giant-cell tumor of bone treated by denosumab

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AU - Yi, Jisook

AU - Lee, Young Han

AU - Kim, Sang Kyum

AU - Kim, Seung Hyun

AU - Song, Ho Taek

AU - Shin, Kyoo Ho

AU - Suh, Jinsuck

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N2 - Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.

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