Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images

Jisook Yi, Young Han Lee, Sang Kyum Kim, Seung Hyun Kim, Ho Taek Song, Kyoo Ho Shin, Jin Suck Suh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.

Original languageEnglish
Pages (from-to)570-577
Number of pages8
JournalJournal of Orthopaedic Science
Volume23
Issue number3
DOIs
Publication statusPublished - 2018 May

Fingerprint

Giant Cell Tumor of Bone
Tomography
Therapeutics
Denosumab
Neoplasms
Research Ethics Committees
Entropy
Osteoclasts
Giant Cells

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Yi, Jisook ; Lee, Young Han ; Kim, Sang Kyum ; Kim, Seung Hyun ; Song, Ho Taek ; Shin, Kyoo Ho ; Suh, Jin Suck. / Response evaluation of giant-cell tumor of bone treated by denosumab : Histogram and texture analysis of CT images. In: Journal of Orthopaedic Science. 2018 ; Vol. 23, No. 3. pp. 570-577.
@article{4737c20c37864d6988035ceebcdb56c4,
title = "Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images",
abstract = "Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.",
author = "Jisook Yi and Lee, {Young Han} and Kim, {Sang Kyum} and Kim, {Seung Hyun} and Song, {Ho Taek} and Shin, {Kyoo Ho} and Suh, {Jin Suck}",
year = "2018",
month = "5",
doi = "10.1016/j.jos.2018.01.006",
language = "English",
volume = "23",
pages = "570--577",
journal = "Journal of Orthopaedic Science",
issn = "0949-2658",
publisher = "Springer Japan",
number = "3",

}

Response evaluation of giant-cell tumor of bone treated by denosumab : Histogram and texture analysis of CT images. / Yi, Jisook; Lee, Young Han; Kim, Sang Kyum; Kim, Seung Hyun; Song, Ho Taek; Shin, Kyoo Ho; Suh, Jin Suck.

In: Journal of Orthopaedic Science, Vol. 23, No. 3, 05.2018, p. 570-577.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Response evaluation of giant-cell tumor of bone treated by denosumab

T2 - Histogram and texture analysis of CT images

AU - Yi, Jisook

AU - Lee, Young Han

AU - Kim, Sang Kyum

AU - Kim, Seung Hyun

AU - Song, Ho Taek

AU - Shin, Kyoo Ho

AU - Suh, Jin Suck

PY - 2018/5

Y1 - 2018/5

N2 - Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.

AB - Background: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. Methods: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. Results: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. Conclusion: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.

UR - http://www.scopus.com/inward/record.url?scp=85044786095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044786095&partnerID=8YFLogxK

U2 - 10.1016/j.jos.2018.01.006

DO - 10.1016/j.jos.2018.01.006

M3 - Article

C2 - 29429890

AN - SCOPUS:85044786095

VL - 23

SP - 570

EP - 577

JO - Journal of Orthopaedic Science

JF - Journal of Orthopaedic Science

SN - 0949-2658

IS - 3

ER -