Restenosis and adverse clinical events after successful percutaneous mitral valvuloplasty: Immediate post-procedural mitral valve area as an important prognosticator

Jae Kwan Song, Jong Min Song, Duk Hyun Kang, Sung Cheol Yun, Duk Woo Park, Seung Whan Lee, Young Hak Kim, Cheol Whan Lee, Myeong Ki Hong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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Abstract

Aims: We sought to investigate the factors associated with restenosis and its potential association with late clinical deterioration after successful percutaneous mitral valvuloplasty (PMV).Methods and resultsWe analysed echocardiographic (median 74 months) and clinical (median 109 months) follow-up data of 329 patients who achieved procedural success, defined as mitral valve area (MVA) ≥1.5 cm2 and mitral regurgitation (MR) ≤2/4, between 1995 and 2000. Clinical events included cardiovascular death, mitral valve surgery, and repeat PMV. The 1, 3, 5, 7, and 9 year rates of restenosis-free survival were 99 ± 1, 97 ± 1, 95 ± 1, 86 ± 3, and 72 ± 4, respectively. The 1, 3, 5, 7, and 9 year rates of event-free survival were 99.7 ± 0.3, 96.4 ± 1.0, 94.5 ± 1.3, 90.8 ± 1.6, and 90.0 ± 1.7, respectively. Immediate post-PMV MVA and commissural MR or splitting, indicators of procedural adequacy, were independent predictors of both restenosis and clinical events. The best immediate post-PMV MVA cut-off value for predicting both restenosis and clinical events within 5 years after successful PMV were 1.8 cm2 [95 confidence interval (CI) = 1.7-1.9] and 1.9 cm2 (95 CI = 1.7-2.0), respectively. Patients with immediate post-PMV MVA <1.8 cm2 showed significantly lower event-free survival rate than those with post-PMV MVA ≥1.8 cm2 (P < 0.001).ConclusionImmediate post-PMV MVA≥1.8 cm2 was an important predictor of both restenosis- and clinical event-free survival and this value should be considered as a component of optimal result.

Original languageEnglish
Pages (from-to)1254-1262
Number of pages9
JournalEuropean heart journal
Volume30
Issue number10
DOIs
Publication statusPublished - 2009 May 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Song, J. K., Song, J. M., Kang, D. H., Yun, S. C., Park, D. W., Lee, S. W., Kim, Y. H., Lee, C. W., Hong, M. K., Kim, J. J., Park, S. W., & Park, S. J. (2009). Restenosis and adverse clinical events after successful percutaneous mitral valvuloplasty: Immediate post-procedural mitral valve area as an important prognosticator. European heart journal, 30(10), 1254-1262. https://doi.org/10.1093/eurheartj/ehp096