Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence

Jihye Park, Jae Hyun Kim, Yehyun Park, Soo Jung Park, Jae Hee Cheon, Won Ho Kim, Ji Soo Park, Justin Y. Jeon, Tae Il Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and aim: High heart rate is an independent predictor of total cancer incidence and all-cause mortality in patients with cancer. We aimed to evaluate the impact of resting heart rate on the recurrence of colorectal polyp, using long-term surveillance follow-up data of colorectal cancer survivors. Methods: Three hundred patients were selected from the colorectal cancer survivor cohort of Severance Hospital, Seoul, Korea. Resting heart rate, physical activity, and body composition analysis at the time of 5-year survival, and clinical data including colonoscopy surveillance results were collected for mean follow-up duration of 8 years. Results: Patients with a high resting heart rate showed a significantly higher recurrence rate of advanced adenoma than those with a low resting heart rate (quartile 1, 45-66 beats per minute (b.p.m.); quartile 2, 67-73 b.p.m.; quartile 3, 74-80 b.p.m.; quartile 4, 81-120 b.p.m.; 3.8% vs. 7.9% vs. 10.0% vs. 14.7%, p for trend = 0.018). After adjustment for various risk factors, patients in the highest quartile of resting heart rate (> 81 b.p.m.) had a significantly higher risk of advanced adenoma recurrence (hazard ratio [HR]: 6.183, 95% confidence interval [CI]: 1.181-32.373, p = 0.031), compared to those in the lowest quartile (< 66 b.p. m.). In subgroup analysis, the association of resting heart rate with advanced adenoma recurrence appeared to be stronger among patients who had more than normal body fat mass or sedentary life style. Conclusions: Elevated resting heart rate was independently associated with a higher rate of advanced adenoma recurrence in colorectal cancer survivors.

Original languageEnglish
Article numbere0193753
JournalPloS one
Volume13
Issue number3
DOIs
Publication statusPublished - 2018 Mar

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adenoma
Adenoma
heart rate
Heart Rate
Recurrence
colorectal neoplasms
Survivors
Colorectal Neoplasms
colonoscopy
neoplasms
monitoring
Colonoscopy
Korea
Polyps
Body Composition
physical activity
body fat
lifestyle
body composition
Korean Peninsula

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Park, J., Kim, J. H., Park, Y., Park, S. J., Cheon, J. H., Kim, W. H., ... Kim, T. I. (2018). Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. PloS one, 13(3), [e0193753]. https://doi.org/10.1371/journal.pone.0193753
Park, Jihye ; Kim, Jae Hyun ; Park, Yehyun ; Park, Soo Jung ; Cheon, Jae Hee ; Kim, Won Ho ; Park, Ji Soo ; Jeon, Justin Y. ; Kim, Tae Il. / Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. In: PloS one. 2018 ; Vol. 13, No. 3.
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title = "Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence",
abstract = "Background and aim: High heart rate is an independent predictor of total cancer incidence and all-cause mortality in patients with cancer. We aimed to evaluate the impact of resting heart rate on the recurrence of colorectal polyp, using long-term surveillance follow-up data of colorectal cancer survivors. Methods: Three hundred patients were selected from the colorectal cancer survivor cohort of Severance Hospital, Seoul, Korea. Resting heart rate, physical activity, and body composition analysis at the time of 5-year survival, and clinical data including colonoscopy surveillance results were collected for mean follow-up duration of 8 years. Results: Patients with a high resting heart rate showed a significantly higher recurrence rate of advanced adenoma than those with a low resting heart rate (quartile 1, 45-66 beats per minute (b.p.m.); quartile 2, 67-73 b.p.m.; quartile 3, 74-80 b.p.m.; quartile 4, 81-120 b.p.m.; 3.8{\%} vs. 7.9{\%} vs. 10.0{\%} vs. 14.7{\%}, p for trend = 0.018). After adjustment for various risk factors, patients in the highest quartile of resting heart rate (> 81 b.p.m.) had a significantly higher risk of advanced adenoma recurrence (hazard ratio [HR]: 6.183, 95{\%} confidence interval [CI]: 1.181-32.373, p = 0.031), compared to those in the lowest quartile (< 66 b.p. m.). In subgroup analysis, the association of resting heart rate with advanced adenoma recurrence appeared to be stronger among patients who had more than normal body fat mass or sedentary life style. Conclusions: Elevated resting heart rate was independently associated with a higher rate of advanced adenoma recurrence in colorectal cancer survivors.",
author = "Jihye Park and Kim, {Jae Hyun} and Yehyun Park and Park, {Soo Jung} and Cheon, {Jae Hee} and Kim, {Won Ho} and Park, {Ji Soo} and Jeon, {Justin Y.} and Kim, {Tae Il}",
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Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. / Park, Jihye; Kim, Jae Hyun; Park, Yehyun; Park, Soo Jung; Cheon, Jae Hee; Kim, Won Ho; Park, Ji Soo; Jeon, Justin Y.; Kim, Tae Il.

In: PloS one, Vol. 13, No. 3, e0193753, 03.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence

AU - Park, Jihye

AU - Kim, Jae Hyun

AU - Park, Yehyun

AU - Park, Soo Jung

AU - Cheon, Jae Hee

AU - Kim, Won Ho

AU - Park, Ji Soo

AU - Jeon, Justin Y.

AU - Kim, Tae Il

PY - 2018/3

Y1 - 2018/3

N2 - Background and aim: High heart rate is an independent predictor of total cancer incidence and all-cause mortality in patients with cancer. We aimed to evaluate the impact of resting heart rate on the recurrence of colorectal polyp, using long-term surveillance follow-up data of colorectal cancer survivors. Methods: Three hundred patients were selected from the colorectal cancer survivor cohort of Severance Hospital, Seoul, Korea. Resting heart rate, physical activity, and body composition analysis at the time of 5-year survival, and clinical data including colonoscopy surveillance results were collected for mean follow-up duration of 8 years. Results: Patients with a high resting heart rate showed a significantly higher recurrence rate of advanced adenoma than those with a low resting heart rate (quartile 1, 45-66 beats per minute (b.p.m.); quartile 2, 67-73 b.p.m.; quartile 3, 74-80 b.p.m.; quartile 4, 81-120 b.p.m.; 3.8% vs. 7.9% vs. 10.0% vs. 14.7%, p for trend = 0.018). After adjustment for various risk factors, patients in the highest quartile of resting heart rate (> 81 b.p.m.) had a significantly higher risk of advanced adenoma recurrence (hazard ratio [HR]: 6.183, 95% confidence interval [CI]: 1.181-32.373, p = 0.031), compared to those in the lowest quartile (< 66 b.p. m.). In subgroup analysis, the association of resting heart rate with advanced adenoma recurrence appeared to be stronger among patients who had more than normal body fat mass or sedentary life style. Conclusions: Elevated resting heart rate was independently associated with a higher rate of advanced adenoma recurrence in colorectal cancer survivors.

AB - Background and aim: High heart rate is an independent predictor of total cancer incidence and all-cause mortality in patients with cancer. We aimed to evaluate the impact of resting heart rate on the recurrence of colorectal polyp, using long-term surveillance follow-up data of colorectal cancer survivors. Methods: Three hundred patients were selected from the colorectal cancer survivor cohort of Severance Hospital, Seoul, Korea. Resting heart rate, physical activity, and body composition analysis at the time of 5-year survival, and clinical data including colonoscopy surveillance results were collected for mean follow-up duration of 8 years. Results: Patients with a high resting heart rate showed a significantly higher recurrence rate of advanced adenoma than those with a low resting heart rate (quartile 1, 45-66 beats per minute (b.p.m.); quartile 2, 67-73 b.p.m.; quartile 3, 74-80 b.p.m.; quartile 4, 81-120 b.p.m.; 3.8% vs. 7.9% vs. 10.0% vs. 14.7%, p for trend = 0.018). After adjustment for various risk factors, patients in the highest quartile of resting heart rate (> 81 b.p.m.) had a significantly higher risk of advanced adenoma recurrence (hazard ratio [HR]: 6.183, 95% confidence interval [CI]: 1.181-32.373, p = 0.031), compared to those in the lowest quartile (< 66 b.p. m.). In subgroup analysis, the association of resting heart rate with advanced adenoma recurrence appeared to be stronger among patients who had more than normal body fat mass or sedentary life style. Conclusions: Elevated resting heart rate was independently associated with a higher rate of advanced adenoma recurrence in colorectal cancer survivors.

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DO - 10.1371/journal.pone.0193753

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