Restoration of bone turnover rate after decompression surgery in patients with symptomatic lumbar spinal stenosis

Preliminary report

Ho Joong Kim, Hwan Mo Lee, Heoung Jae Chun, Kyoung Tak Kang, Hak Sun Kim, Jin Oh Park, Eun Su Moon, Kwang Hwan Park, seonghwan moon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

STUDY DESIGN. Prospective short-term longitudinal study. OBJECTIVE. To investigate changes in the bone turnover rate in patients with lumbar spinal stenosis (LSS) before and after decompression surgery. SUMMARY OF BACK GROUND DATA. Decompression surgery enables elderly patients with LSS to participate in daily activities and physical exercise by reducing or alleviating leg and back pain. However, there have been no studies to date regarding the effect of decompression surgery on bone metabolism in such patients. METHODS. Twenty-three patients with spinal stenosis who were scheduled to undergo decompression surgery were enrolled in our study. Ten patients were given oral bisphosphonates after the operation (B+ group), while the remaining 13 patients did not receive oral bisphosphonate (B- group). In both groups, walking distance without rest, the Oswestry Disability Index (ODI) scores, duration of symptoms, bone formation, and resorption markers, and bone mineral density were recorded before surgery. Three months after surgery, bone turnover markers, a single trial for walking distance without rest and ODI scores were measured for both groups. RESULTS. Three months after the operation, the bone resorption marker u-NTx was decreased significantly for both groups. Although there was a decrease in bALP, a bone formation maker, in both groups, the change in each group was not statistical significant. Distance in a single trial walk was increased and ODI scores were decreased significantly for both groups. CONCLUSION. This study suggests that decompression surgery has a beneficial effect on bone metabolism in patients with LSS who have walking intolerance and limited physical activity.

Original languageEnglish
JournalSpine
Volume34
Issue number18
DOIs
Publication statusPublished - 2009 Aug 1

Fingerprint

Spinal Stenosis
Bone Remodeling
Decompression
Walking
Diphosphonates
Bone Resorption
Osteogenesis
Exercise
Bone and Bones
Back Pain
Bone Density
Longitudinal Studies
Leg

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Kim, Ho Joong ; Lee, Hwan Mo ; Chun, Heoung Jae ; Kang, Kyoung Tak ; Kim, Hak Sun ; Park, Jin Oh ; Moon, Eun Su ; Park, Kwang Hwan ; moon, seonghwan. / Restoration of bone turnover rate after decompression surgery in patients with symptomatic lumbar spinal stenosis : Preliminary report. In: Spine. 2009 ; Vol. 34, No. 18.
@article{c24654f44e824b56aef92879281cdd98,
title = "Restoration of bone turnover rate after decompression surgery in patients with symptomatic lumbar spinal stenosis: Preliminary report",
abstract = "STUDY DESIGN. Prospective short-term longitudinal study. OBJECTIVE. To investigate changes in the bone turnover rate in patients with lumbar spinal stenosis (LSS) before and after decompression surgery. SUMMARY OF BACK GROUND DATA. Decompression surgery enables elderly patients with LSS to participate in daily activities and physical exercise by reducing or alleviating leg and back pain. However, there have been no studies to date regarding the effect of decompression surgery on bone metabolism in such patients. METHODS. Twenty-three patients with spinal stenosis who were scheduled to undergo decompression surgery were enrolled in our study. Ten patients were given oral bisphosphonates after the operation (B+ group), while the remaining 13 patients did not receive oral bisphosphonate (B- group). In both groups, walking distance without rest, the Oswestry Disability Index (ODI) scores, duration of symptoms, bone formation, and resorption markers, and bone mineral density were recorded before surgery. Three months after surgery, bone turnover markers, a single trial for walking distance without rest and ODI scores were measured for both groups. RESULTS. Three months after the operation, the bone resorption marker u-NTx was decreased significantly for both groups. Although there was a decrease in bALP, a bone formation maker, in both groups, the change in each group was not statistical significant. Distance in a single trial walk was increased and ODI scores were decreased significantly for both groups. CONCLUSION. This study suggests that decompression surgery has a beneficial effect on bone metabolism in patients with LSS who have walking intolerance and limited physical activity.",
author = "Kim, {Ho Joong} and Lee, {Hwan Mo} and Chun, {Heoung Jae} and Kang, {Kyoung Tak} and Kim, {Hak Sun} and Park, {Jin Oh} and Moon, {Eun Su} and Park, {Kwang Hwan} and seonghwan moon",
year = "2009",
month = "8",
day = "1",
doi = "10.1097/BRS.0b013e3181ab3e88",
language = "English",
volume = "34",
journal = "Spine",
issn = "0362-2436",
publisher = "Lippincott Williams and Wilkins",
number = "18",

}

Restoration of bone turnover rate after decompression surgery in patients with symptomatic lumbar spinal stenosis : Preliminary report. / Kim, Ho Joong; Lee, Hwan Mo; Chun, Heoung Jae; Kang, Kyoung Tak; Kim, Hak Sun; Park, Jin Oh; Moon, Eun Su; Park, Kwang Hwan; moon, seonghwan.

In: Spine, Vol. 34, No. 18, 01.08.2009.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Restoration of bone turnover rate after decompression surgery in patients with symptomatic lumbar spinal stenosis

T2 - Preliminary report

AU - Kim, Ho Joong

AU - Lee, Hwan Mo

AU - Chun, Heoung Jae

AU - Kang, Kyoung Tak

AU - Kim, Hak Sun

AU - Park, Jin Oh

AU - Moon, Eun Su

AU - Park, Kwang Hwan

AU - moon, seonghwan

PY - 2009/8/1

Y1 - 2009/8/1

N2 - STUDY DESIGN. Prospective short-term longitudinal study. OBJECTIVE. To investigate changes in the bone turnover rate in patients with lumbar spinal stenosis (LSS) before and after decompression surgery. SUMMARY OF BACK GROUND DATA. Decompression surgery enables elderly patients with LSS to participate in daily activities and physical exercise by reducing or alleviating leg and back pain. However, there have been no studies to date regarding the effect of decompression surgery on bone metabolism in such patients. METHODS. Twenty-three patients with spinal stenosis who were scheduled to undergo decompression surgery were enrolled in our study. Ten patients were given oral bisphosphonates after the operation (B+ group), while the remaining 13 patients did not receive oral bisphosphonate (B- group). In both groups, walking distance without rest, the Oswestry Disability Index (ODI) scores, duration of symptoms, bone formation, and resorption markers, and bone mineral density were recorded before surgery. Three months after surgery, bone turnover markers, a single trial for walking distance without rest and ODI scores were measured for both groups. RESULTS. Three months after the operation, the bone resorption marker u-NTx was decreased significantly for both groups. Although there was a decrease in bALP, a bone formation maker, in both groups, the change in each group was not statistical significant. Distance in a single trial walk was increased and ODI scores were decreased significantly for both groups. CONCLUSION. This study suggests that decompression surgery has a beneficial effect on bone metabolism in patients with LSS who have walking intolerance and limited physical activity.

AB - STUDY DESIGN. Prospective short-term longitudinal study. OBJECTIVE. To investigate changes in the bone turnover rate in patients with lumbar spinal stenosis (LSS) before and after decompression surgery. SUMMARY OF BACK GROUND DATA. Decompression surgery enables elderly patients with LSS to participate in daily activities and physical exercise by reducing or alleviating leg and back pain. However, there have been no studies to date regarding the effect of decompression surgery on bone metabolism in such patients. METHODS. Twenty-three patients with spinal stenosis who were scheduled to undergo decompression surgery were enrolled in our study. Ten patients were given oral bisphosphonates after the operation (B+ group), while the remaining 13 patients did not receive oral bisphosphonate (B- group). In both groups, walking distance without rest, the Oswestry Disability Index (ODI) scores, duration of symptoms, bone formation, and resorption markers, and bone mineral density were recorded before surgery. Three months after surgery, bone turnover markers, a single trial for walking distance without rest and ODI scores were measured for both groups. RESULTS. Three months after the operation, the bone resorption marker u-NTx was decreased significantly for both groups. Although there was a decrease in bALP, a bone formation maker, in both groups, the change in each group was not statistical significant. Distance in a single trial walk was increased and ODI scores were decreased significantly for both groups. CONCLUSION. This study suggests that decompression surgery has a beneficial effect on bone metabolism in patients with LSS who have walking intolerance and limited physical activity.

UR - http://www.scopus.com/inward/record.url?scp=69749126985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69749126985&partnerID=8YFLogxK

U2 - 10.1097/BRS.0b013e3181ab3e88

DO - 10.1097/BRS.0b013e3181ab3e88

M3 - Article

VL - 34

JO - Spine

JF - Spine

SN - 0362-2436

IS - 18

ER -