Restoration of P-glycoprotein Function is Involved in the Increase of Natural Killer Activity with Exogenous Interleukin-15 in Human Immunodeficiency Virus-infected Individuals

Kyung Hee Chang, June Myung Kim, Nae Choon Yoo, Won Ho Kim, Jeon Han Park, In Hong Choi, Hyun Sook Kim, Kyungwon Lee, Young Goo Song, Sung Kwan Hong, Hyo Yeul Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1 α (MIP-1 α), macrophage chemotactic protein-1 (MCP-1) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalYonsei Medical Journal
Volume41
Issue number5
DOIs
Publication statusPublished - 2000 Jan 1

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Interleukin-15
Population Growth
P-Glycoprotein
HIV
Natural Killer Cells
CC Chemokines
Virus Diseases
Macrophage Inflammatory Proteins
Macrophages
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chang, Kyung Hee ; Kim, June Myung ; Yoo, Nae Choon ; Kim, Won Ho ; Park, Jeon Han ; Choi, In Hong ; Kim, Hyun Sook ; Lee, Kyungwon ; Song, Young Goo ; Hong, Sung Kwan ; Kim, Hyo Yeul. / Restoration of P-glycoprotein Function is Involved in the Increase of Natural Killer Activity with Exogenous Interleukin-15 in Human Immunodeficiency Virus-infected Individuals. In: Yonsei Medical Journal. 2000 ; Vol. 41, No. 5. pp. 600-606.
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abstract = "A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1 α (MIP-1 α), macrophage chemotactic protein-1 (MCP-1) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation.",
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Restoration of P-glycoprotein Function is Involved in the Increase of Natural Killer Activity with Exogenous Interleukin-15 in Human Immunodeficiency Virus-infected Individuals. / Chang, Kyung Hee; Kim, June Myung; Yoo, Nae Choon; Kim, Won Ho; Park, Jeon Han; Choi, In Hong; Kim, Hyun Sook; Lee, Kyungwon; Song, Young Goo; Hong, Sung Kwan; Kim, Hyo Yeul.

In: Yonsei Medical Journal, Vol. 41, No. 5, 01.01.2000, p. 600-606.

Research output: Contribution to journalArticle

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