Restoration of P-glycoprotein Function is Involved in the Increase of Natural Killer Activity with Exogenous Interleukin-15 in Human Immunodeficiency Virus-infected Individuals

Kyung Hee Chang, June Myung Kim, Nae Choon Yoo, Won Ho Kim, Jeon Han Park, In Hong Choi, Hyun Sook Kim, Kyung Won Lee, Young Goo Song, Sung Kwan Hong, Hyo Yeul Kim

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A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1 α (MIP-1 α), macrophage chemotactic protein-1 (MCP-1) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalYonsei medical journal
Issue number5
Publication statusPublished - 2000 Oct


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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