Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore

D. Torumkuney, R. Chaiwarith, W. Reechaipichitkul, K. Malatham, V. Chareonphaibul, C. Rodrigues, D. S. Chitins, M. Dias, S. Anandan, S. Kanakapura, Y. J. Park, Kyungwon Lee, H. Lee, J. Y. Kim, Y. Lee, H. K. Lee, J. H. Kim, T. Y. Tan, Y. X. Heng, P. Mukherjee & 1 others I. Morrissey

Research output: Contribution to journalArticle

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Abstract

Objectives: To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012-14 from four Asian countries. Methods: MICs were determined using Etest® for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available. Results: Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from21.2%in South Korea to 63.8%in Singapore. In contrast, susceptibility using CLSI intravenous breakpointswasmuch higher, at 79%in South Korea and ~95%or higher elsewhere. Macrolide susceptibility was ~20% in South Korea and ~50%-60% elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (~20%) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7% in South Korea to 91.1% in India. South Korea also had a high percentage (18.1%) of b-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93% and 100% in all countries except for H. influenzae in South Korea (62.5%). Conclusions: Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCASTshowing lower susceptibility. Therewas considerable variability in susceptibilityamong countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.

Original languageEnglish
Pages (from-to)i3-i19
JournalJournal of Antimicrobial Chemotherapy
Volume71
DOIs
Publication statusPublished - 2016 May 1

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Republic of Korea
Singapore
Thailand
Microbial Drug Resistance
India
Haemophilus influenzae
Streptococcus pyogenes
Macrolides
Erythromycin
Ampicillin
Anti-Bacterial Agents
Streptococcus pneumoniae
Disk Diffusion Antimicrobial Tests
Pharmacokinetics
Cefaclor
Moraxella (Branhamella) catarrhalis
Amoxicillin-Potassium Clavulanate Combination
Cefuroxime
Ofloxacin
Clindamycin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Torumkuney, D., Chaiwarith, R., Reechaipichitkul, W., Malatham, K., Chareonphaibul, V., Rodrigues, C., ... Morrissey, I. (2016). Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore. Journal of Antimicrobial Chemotherapy, 71, i3-i19. https://doi.org/10.1093/jac/dkw073
Torumkuney, D. ; Chaiwarith, R. ; Reechaipichitkul, W. ; Malatham, K. ; Chareonphaibul, V. ; Rodrigues, C. ; Chitins, D. S. ; Dias, M. ; Anandan, S. ; Kanakapura, S. ; Park, Y. J. ; Lee, Kyungwon ; Lee, H. ; Kim, J. Y. ; Lee, Y. ; Lee, H. K. ; Kim, J. H. ; Tan, T. Y. ; Heng, Y. X. ; Mukherjee, P. ; Morrissey, I. / Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore. In: Journal of Antimicrobial Chemotherapy. 2016 ; Vol. 71. pp. i3-i19.
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abstract = "Objectives: To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012-14 from four Asian countries. Methods: MICs were determined using Etest{\circledR} for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available. Results: Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from21.2{\%}in South Korea to 63.8{\%}in Singapore. In contrast, susceptibility using CLSI intravenous breakpointswasmuch higher, at 79{\%}in South Korea and ~95{\%}or higher elsewhere. Macrolide susceptibility was ~20{\%} in South Korea and ~50{\%}-60{\%} elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (~20{\%}) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7{\%} in South Korea to 91.1{\%} in India. South Korea also had a high percentage (18.1{\%}) of b-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93{\%} and 100{\%} in all countries except for H. influenzae in South Korea (62.5{\%}). Conclusions: Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCASTshowing lower susceptibility. Therewas considerable variability in susceptibilityamong countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.",
author = "D. Torumkuney and R. Chaiwarith and W. Reechaipichitkul and K. Malatham and V. Chareonphaibul and C. Rodrigues and Chitins, {D. S.} and M. Dias and S. Anandan and S. Kanakapura and Park, {Y. J.} and Kyungwon Lee and H. Lee and Kim, {J. Y.} and Y. Lee and Lee, {H. K.} and Kim, {J. H.} and Tan, {T. Y.} and Heng, {Y. X.} and P. Mukherjee and I. Morrissey",
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Torumkuney, D, Chaiwarith, R, Reechaipichitkul, W, Malatham, K, Chareonphaibul, V, Rodrigues, C, Chitins, DS, Dias, M, Anandan, S, Kanakapura, S, Park, YJ, Lee, K, Lee, H, Kim, JY, Lee, Y, Lee, HK, Kim, JH, Tan, TY, Heng, YX, Mukherjee, P & Morrissey, I 2016, 'Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore', Journal of Antimicrobial Chemotherapy, vol. 71, pp. i3-i19. https://doi.org/10.1093/jac/dkw073

Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore. / Torumkuney, D.; Chaiwarith, R.; Reechaipichitkul, W.; Malatham, K.; Chareonphaibul, V.; Rodrigues, C.; Chitins, D. S.; Dias, M.; Anandan, S.; Kanakapura, S.; Park, Y. J.; Lee, Kyungwon; Lee, H.; Kim, J. Y.; Lee, Y.; Lee, H. K.; Kim, J. H.; Tan, T. Y.; Heng, Y. X.; Mukherjee, P.; Morrissey, I.

In: Journal of Antimicrobial Chemotherapy, Vol. 71, 01.05.2016, p. i3-i19.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore

AU - Torumkuney, D.

AU - Chaiwarith, R.

AU - Reechaipichitkul, W.

AU - Malatham, K.

AU - Chareonphaibul, V.

AU - Rodrigues, C.

AU - Chitins, D. S.

AU - Dias, M.

AU - Anandan, S.

AU - Kanakapura, S.

AU - Park, Y. J.

AU - Lee, Kyungwon

AU - Lee, H.

AU - Kim, J. Y.

AU - Lee, Y.

AU - Lee, H. K.

AU - Kim, J. H.

AU - Tan, T. Y.

AU - Heng, Y. X.

AU - Mukherjee, P.

AU - Morrissey, I.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objectives: To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012-14 from four Asian countries. Methods: MICs were determined using Etest® for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available. Results: Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from21.2%in South Korea to 63.8%in Singapore. In contrast, susceptibility using CLSI intravenous breakpointswasmuch higher, at 79%in South Korea and ~95%or higher elsewhere. Macrolide susceptibility was ~20% in South Korea and ~50%-60% elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (~20%) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7% in South Korea to 91.1% in India. South Korea also had a high percentage (18.1%) of b-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93% and 100% in all countries except for H. influenzae in South Korea (62.5%). Conclusions: Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCASTshowing lower susceptibility. Therewas considerable variability in susceptibilityamong countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.

AB - Objectives: To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012-14 from four Asian countries. Methods: MICs were determined using Etest® for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available. Results: Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from21.2%in South Korea to 63.8%in Singapore. In contrast, susceptibility using CLSI intravenous breakpointswasmuch higher, at 79%in South Korea and ~95%or higher elsewhere. Macrolide susceptibility was ~20% in South Korea and ~50%-60% elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (~20%) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7% in South Korea to 91.1% in India. South Korea also had a high percentage (18.1%) of b-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93% and 100% in all countries except for H. influenzae in South Korea (62.5%). Conclusions: Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCASTshowing lower susceptibility. Therewas considerable variability in susceptibilityamong countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.

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Torumkuney D, Chaiwarith R, Reechaipichitkul W, Malatham K, Chareonphaibul V, Rodrigues C et al. Results from the Survey of Antibiotic Resistance (SOAR) 2012-14 in Thailand, India, South Korea and Singapore. Journal of Antimicrobial Chemotherapy. 2016 May 1;71:i3-i19. https://doi.org/10.1093/jac/dkw073