Retention esophagitis as a significant clinical predictor of progression to esophageal cancer in achalasia

Haewon Kim, HyoJin Park, Heeseung Choi, Yooju Shin, Hyunsung Park, Young Hoon Youn, Jie-Hyun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: Chronic liquid and/or food stasis caused by retention esophagitis (RE) in achalasia is a notable endoscopic finding because of the presence of a thickened or whitish esophageal mucosa and histologically altered squamous hyperplasia. We aimed to identify the clinical features of RE associated with achalasia and to clarify the clinical definition of RE in achalasia as a precancerous lesion identified by analyzing biomarker expressions. Methods: From 2006 to 2015, we retrospectively reviewed 37 patients with achalasia without previous treatment. Among them, 21 patients had diagnostic findings of RE (RE+) and 16 patients had no diagnostic findings of RE (RE–). Immunohistochemical staining of p53, p16, and Ki-67 was performed on the endoscopic biopsy tissues from the patients with achalasia and 10 control patients with non-obstructive dysphagia. Results: The symptom duration and transit delay were significantly longer in the RE+ group than in the RE– group. We found particularly high p53 positivity rates in the RE+ group (p<0.001). The rate of p16 expression was also significantly higher in the RE+ group than in the other two groups (p=0.003). Conclusions: A high p53 expression rate was more frequently found in the RE+ group than in the other two groups. RE could be a meaningful clinical feature of achalasia for predicting esophageal carcinogenesis.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalClinical Endoscopy
Volume51
Issue number2
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Esophageal Achalasia
Esophagitis
Esophageal Neoplasms
Deglutition Disorders
Hyperplasia
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Kim, Haewon ; Park, HyoJin ; Choi, Heeseung ; Shin, Yooju ; Park, Hyunsung ; Youn, Young Hoon ; Kim, Jie-Hyun. / Retention esophagitis as a significant clinical predictor of progression to esophageal cancer in achalasia. In: Clinical Endoscopy. 2018 ; Vol. 51, No. 2. pp. 161-166.
@article{03e1017761b74e9582d6c9b2b4adda84,
title = "Retention esophagitis as a significant clinical predictor of progression to esophageal cancer in achalasia",
abstract = "Background/Aims: Chronic liquid and/or food stasis caused by retention esophagitis (RE) in achalasia is a notable endoscopic finding because of the presence of a thickened or whitish esophageal mucosa and histologically altered squamous hyperplasia. We aimed to identify the clinical features of RE associated with achalasia and to clarify the clinical definition of RE in achalasia as a precancerous lesion identified by analyzing biomarker expressions. Methods: From 2006 to 2015, we retrospectively reviewed 37 patients with achalasia without previous treatment. Among them, 21 patients had diagnostic findings of RE (RE+) and 16 patients had no diagnostic findings of RE (RE–). Immunohistochemical staining of p53, p16, and Ki-67 was performed on the endoscopic biopsy tissues from the patients with achalasia and 10 control patients with non-obstructive dysphagia. Results: The symptom duration and transit delay were significantly longer in the RE+ group than in the RE– group. We found particularly high p53 positivity rates in the RE+ group (p<0.001). The rate of p16 expression was also significantly higher in the RE+ group than in the other two groups (p=0.003). Conclusions: A high p53 expression rate was more frequently found in the RE+ group than in the other two groups. RE could be a meaningful clinical feature of achalasia for predicting esophageal carcinogenesis.",
author = "Haewon Kim and HyoJin Park and Heeseung Choi and Yooju Shin and Hyunsung Park and Youn, {Young Hoon} and Jie-Hyun Kim",
year = "2018",
month = "3",
day = "1",
doi = "10.5946/ce.2017.087",
language = "English",
volume = "51",
pages = "161--166",
journal = "Clinical Endoscopy",
issn = "2234-2400",
publisher = "Korean Society of Gastrointestinal Endoscopy",
number = "2",

}

Retention esophagitis as a significant clinical predictor of progression to esophageal cancer in achalasia. / Kim, Haewon; Park, HyoJin; Choi, Heeseung; Shin, Yooju; Park, Hyunsung; Youn, Young Hoon; Kim, Jie-Hyun.

In: Clinical Endoscopy, Vol. 51, No. 2, 01.03.2018, p. 161-166.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Retention esophagitis as a significant clinical predictor of progression to esophageal cancer in achalasia

AU - Kim, Haewon

AU - Park, HyoJin

AU - Choi, Heeseung

AU - Shin, Yooju

AU - Park, Hyunsung

AU - Youn, Young Hoon

AU - Kim, Jie-Hyun

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background/Aims: Chronic liquid and/or food stasis caused by retention esophagitis (RE) in achalasia is a notable endoscopic finding because of the presence of a thickened or whitish esophageal mucosa and histologically altered squamous hyperplasia. We aimed to identify the clinical features of RE associated with achalasia and to clarify the clinical definition of RE in achalasia as a precancerous lesion identified by analyzing biomarker expressions. Methods: From 2006 to 2015, we retrospectively reviewed 37 patients with achalasia without previous treatment. Among them, 21 patients had diagnostic findings of RE (RE+) and 16 patients had no diagnostic findings of RE (RE–). Immunohistochemical staining of p53, p16, and Ki-67 was performed on the endoscopic biopsy tissues from the patients with achalasia and 10 control patients with non-obstructive dysphagia. Results: The symptom duration and transit delay were significantly longer in the RE+ group than in the RE– group. We found particularly high p53 positivity rates in the RE+ group (p<0.001). The rate of p16 expression was also significantly higher in the RE+ group than in the other two groups (p=0.003). Conclusions: A high p53 expression rate was more frequently found in the RE+ group than in the other two groups. RE could be a meaningful clinical feature of achalasia for predicting esophageal carcinogenesis.

AB - Background/Aims: Chronic liquid and/or food stasis caused by retention esophagitis (RE) in achalasia is a notable endoscopic finding because of the presence of a thickened or whitish esophageal mucosa and histologically altered squamous hyperplasia. We aimed to identify the clinical features of RE associated with achalasia and to clarify the clinical definition of RE in achalasia as a precancerous lesion identified by analyzing biomarker expressions. Methods: From 2006 to 2015, we retrospectively reviewed 37 patients with achalasia without previous treatment. Among them, 21 patients had diagnostic findings of RE (RE+) and 16 patients had no diagnostic findings of RE (RE–). Immunohistochemical staining of p53, p16, and Ki-67 was performed on the endoscopic biopsy tissues from the patients with achalasia and 10 control patients with non-obstructive dysphagia. Results: The symptom duration and transit delay were significantly longer in the RE+ group than in the RE– group. We found particularly high p53 positivity rates in the RE+ group (p<0.001). The rate of p16 expression was also significantly higher in the RE+ group than in the other two groups (p=0.003). Conclusions: A high p53 expression rate was more frequently found in the RE+ group than in the other two groups. RE could be a meaningful clinical feature of achalasia for predicting esophageal carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=85044786844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044786844&partnerID=8YFLogxK

U2 - 10.5946/ce.2017.087

DO - 10.5946/ce.2017.087

M3 - Article

VL - 51

SP - 161

EP - 166

JO - Clinical Endoscopy

JF - Clinical Endoscopy

SN - 2234-2400

IS - 2

ER -