Retinal ganglion cell responses to voltage and current stimulation in wild-type and rd1 mouse retinas

Yong Sook Goo, Jang Hee Ye, Seokyoung Lee, Yoonkey Nam, Sang Baek Ryu, Kyung Hwan Kim

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Retinal prostheses are being developed to restore vision for those with retinal diseases such as retinitis pigmentosa or age-related macular degeneration. Since neural prostheses depend upon electrical stimulation to control neural activity, optimal stimulation parameters for successful encoding of visual information are one of the most important requirements to enable visual perception. In this paper, we focused on retinal ganglion cell (RGC) responses to different stimulation parameters and compared threshold charge densities in wild-type and rd1 mice. For this purpose, we used in vitro retinal preparations of wild-type and rd1 mice. When the neural network was stimulated with voltage- and current-controlled pulses, RGCs from both wild-type and rd1 mice responded; however the temporal pattern of RGC response is very different. In wild-type RGCs, a single peak within 100 ms appears, while multiple peaks (approximately four peaks) with ∼10 Hz rhythm within 400 ms appear in RGCs in the degenerated retina of rd1 mice. We find that an anodic phase-first biphasic voltage-controlled pulse is more efficient for stimulation than a biphasic current-controlled pulse based on lower threshold charge density. The threshold charge densities for activation of RGCs both with voltage- and current-controlled pulses are overall more elevated for the rd1 mouse than the wild-type mouse. Here, we propose the stimulus range for wild-type and rd1 retinas when the optimal modulation of a RGC response is possible.

Original languageEnglish
Article number035003
JournalJournal of Neural Engineering
Volume8
Issue number3
DOIs
Publication statusPublished - 2011 Jun 1

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Retinal Ganglion Cells
Charge density
Retina
Electric potential
Neural prostheses
Prosthetics
Neural Prostheses
Visual Prosthesis
Chemical activation
Modulation
Neural networks
Retinal Diseases
Visual Perception
Retinitis Pigmentosa
Macular Degeneration
Electric Stimulation

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience

Cite this

Goo, Yong Sook ; Ye, Jang Hee ; Lee, Seokyoung ; Nam, Yoonkey ; Ryu, Sang Baek ; Kim, Kyung Hwan. / Retinal ganglion cell responses to voltage and current stimulation in wild-type and rd1 mouse retinas. In: Journal of Neural Engineering. 2011 ; Vol. 8, No. 3.
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Retinal ganglion cell responses to voltage and current stimulation in wild-type and rd1 mouse retinas. / Goo, Yong Sook; Ye, Jang Hee; Lee, Seokyoung; Nam, Yoonkey; Ryu, Sang Baek; Kim, Kyung Hwan.

In: Journal of Neural Engineering, Vol. 8, No. 3, 035003, 01.06.2011.

Research output: Contribution to journalArticle

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