Retinal ganglion cell (RGC) responses to different voltage stimulation parameters in rd1 mouse retina

Jang Hee Ye, Sang Baek Ryu, Kyung Hwan Kim, Yong Sook Goo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Retinal prostheses are being developed to restore vision for the blind with retinal diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Since neural prostheses depend upon electrical stimulation to control neural activity, optimal stimulation parameters for successful encoding of visual information are one of the most important requirements to enable visual perception. Therefore, in this paper, we focused on RGC responses to different stimulation parameters in degenerated retina. For this purpose, we used in vitro preparation of rd1 mice retina on microelectrode arrays. When the neural netw ork of rd1 mice retinas is stimulated with voltage-controlled pulses, RGCs in degenerated retina also respond to voltage amplitude or voltage duration modulation as well in wild-type RGCs. But the temporal pattern of RGCs response is very different; in wild-type RGCs, single peak within 100 ms appears while in RGCs in degenerated retina multiple peaks (∼4 peaks) with ∼10 Hz rhythm within 400 ms appear. The threshold charge densities for activation of RGCs in rd1 mouse retinas were on average 70.50 ∼ 99.87 μC/cm 2 in the experiment of voltage amplitude modulation and 120.5 ∼ 170.6 μC/cm2 in the experiment of voltage duration modulation.

Original languageEnglish
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages6761-6764
Number of pages4
DOIs
Publication statusPublished - 2010
Event2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
Duration: 2010 Aug 312010 Sep 4

Publication series

Name2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
CountryArgentina
CityBuenos Aires
Period10/8/3110/9/4

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Health Informatics

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