Retinal nerve fiber layer thickness is decreased in patients with hematologic malignancy

Jinu Han, Ji Hyun Kim, Hanna Yoo, Sueng Han Han, Samin Hong, Gong Je Seong, chanyun kim

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate whether retinal nerve fiber layer (RNFL) thickness is decreased in patients with hematologic malignancy using optical coherence tomography (OCT). Patients and Methods: This prospective, observational crosssectional study included 65 eyes from 34 patients with hematologic malignancy and 72 healthy control eyes. OCT-measured RNFL thickness parameters (average, 4 quadrants, and 12 clock-hour thickness) and RNFL defect in red-free photo were compared between patients with hematologic malignancy and controls. Results: Among average, quadrant, and clock-hour map, the only 11-o'clock RNFL in patients with hematologic malignancy was statistically thinner than in controls (P=0.021). The RNFL defect was detected in 21/65 (32.3%) patients with hematologic malignancy and in 5/72 (6.9%) controls (P<0.001). In patients with hematologic malignancy, the mean RNFL thickness was significantly lower in the severe and moderate anemia groups compared with the mild anemia group (P=0.011). In the generalized estimating equations model, the mean hemoglobin level was associated with RNFL thickness while correcting for inter-eye correlation, age, and refraction error (coefficient=3.685, P=0.006). Conclusions: The RNFL defect was frequently observed, and the RNFL was thinner in severe anemic patients with hematologic malignancy. These results suggest that chronic anemia may be a factor of RNFL loss.

Original languageEnglish
Pages (from-to)e175-e181
JournalJournal of Glaucoma
Volume25
Issue number3
DOIs
Publication statusPublished - 2016 Mar 23

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Hematologic Neoplasms
Nerve Fibers
Anemia
Optical Coherence Tomography
Observational Studies
Hemoglobins

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Han, Jinu ; Kim, Ji Hyun ; Yoo, Hanna ; Han, Sueng Han ; Hong, Samin ; Seong, Gong Je ; kim, chanyun. / Retinal nerve fiber layer thickness is decreased in patients with hematologic malignancy. In: Journal of Glaucoma. 2016 ; Vol. 25, No. 3. pp. e175-e181.
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abstract = "Purpose: To investigate whether retinal nerve fiber layer (RNFL) thickness is decreased in patients with hematologic malignancy using optical coherence tomography (OCT). Patients and Methods: This prospective, observational crosssectional study included 65 eyes from 34 patients with hematologic malignancy and 72 healthy control eyes. OCT-measured RNFL thickness parameters (average, 4 quadrants, and 12 clock-hour thickness) and RNFL defect in red-free photo were compared between patients with hematologic malignancy and controls. Results: Among average, quadrant, and clock-hour map, the only 11-o'clock RNFL in patients with hematologic malignancy was statistically thinner than in controls (P=0.021). The RNFL defect was detected in 21/65 (32.3{\%}) patients with hematologic malignancy and in 5/72 (6.9{\%}) controls (P<0.001). In patients with hematologic malignancy, the mean RNFL thickness was significantly lower in the severe and moderate anemia groups compared with the mild anemia group (P=0.011). In the generalized estimating equations model, the mean hemoglobin level was associated with RNFL thickness while correcting for inter-eye correlation, age, and refraction error (coefficient=3.685, P=0.006). Conclusions: The RNFL defect was frequently observed, and the RNFL was thinner in severe anemic patients with hematologic malignancy. These results suggest that chronic anemia may be a factor of RNFL loss.",
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Retinal nerve fiber layer thickness is decreased in patients with hematologic malignancy. / Han, Jinu; Kim, Ji Hyun; Yoo, Hanna; Han, Sueng Han; Hong, Samin; Seong, Gong Je; kim, chanyun.

In: Journal of Glaucoma, Vol. 25, No. 3, 23.03.2016, p. e175-e181.

Research output: Contribution to journalArticle

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T1 - Retinal nerve fiber layer thickness is decreased in patients with hematologic malignancy

AU - Han, Jinu

AU - Kim, Ji Hyun

AU - Yoo, Hanna

AU - Han, Sueng Han

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AU - Seong, Gong Je

AU - kim, chanyun

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