Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT

Mircea Mujat, Raymond C. Chan, Barry Cense, Mark Pierce, Hyle Park, Chulmin Joo, Teresa C. Chen, Johannes F. De Boer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Spectral-Domain Optical Coherence Tomography (SDOCT) allows for in-vivo video-rate investigation of biomedical tissue depth structure intended for non-invasive optical diagnostics. It has been suggested that OCT can be used for diagnosis of glaucoma by measuring the thickness of the Retinal Nerve Fiber Layer (RNLF). We present an automated method for determining the RNFL thickness from a 3-D dataset based on edge detection using a deformable spline algorithm. The RNFL thickness map is combined with an integrated reflectance map and retinal cross-sectional images to provide the ophthalmologist with a familiar image for interpreting the OCT data. The video-rate capabilities of our SDOCT system allow for mapping the true retinal topography since motion artifacts are significantly reduced as compared to slower time-domain systems. Combined with Doppler Velocimetry, SDOCT also provides information on retinal blood flow dynamics. We analyzed the pulsatile nature of the bidirectional flow dynamics in an artery-vein pair for a healthy volunteer at different locations and for different blood vessel diameters. The Doppler phase shift is determined as the phase difference at the same point of adjacent depth profiles, and is integrated over the area delimited by two circles corresponding to the blood vessels location. Its temporal evolution clearly shows the blood flow pulsatile nature, the cardiac cycle, in both artery and vein. The artery is identified as having a stronger variation of the integrated phase shift. We observe that artery pulsation is always easily detectable, while vein pulsation seems to depend on the veins diameter.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
DOIs
Publication statusPublished - 2006 May 10
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X - San Jose, CA, United States
Duration: 2006 Jan 232006 Jan 25

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6079
ISSN (Print)0277-786X

Other

OtherCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X
CountryUnited States
CitySan Jose, CA
Period06/1/2306/1/25

Fingerprint

nerve fibers
Optical Coherence Tomography
Optical tomography
Veins
Arteries
blood flow
Blood Flow
Nerve
arteries
veins
Blood
tomography
Blood vessels
Fiber
Phase shift
Fibers
Blood Vessels
blood vessels
Doppler
Phase Shift

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Mujat, M., Chan, R. C., Cense, B., Pierce, M., Park, H., Joo, C., ... De Boer, J. F. (2006). Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT. In Proceedings of SPIE - The International Society for Optical Engineering [607909] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6079). https://doi.org/10.1117/12.649095
Mujat, Mircea ; Chan, Raymond C. ; Cense, Barry ; Pierce, Mark ; Park, Hyle ; Joo, Chulmin ; Chen, Teresa C. ; De Boer, Johannes F. / Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT. Proceedings of SPIE - The International Society for Optical Engineering. 2006. (Proceedings of SPIE - The International Society for Optical Engineering).
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abstract = "Spectral-Domain Optical Coherence Tomography (SDOCT) allows for in-vivo video-rate investigation of biomedical tissue depth structure intended for non-invasive optical diagnostics. It has been suggested that OCT can be used for diagnosis of glaucoma by measuring the thickness of the Retinal Nerve Fiber Layer (RNLF). We present an automated method for determining the RNFL thickness from a 3-D dataset based on edge detection using a deformable spline algorithm. The RNFL thickness map is combined with an integrated reflectance map and retinal cross-sectional images to provide the ophthalmologist with a familiar image for interpreting the OCT data. The video-rate capabilities of our SDOCT system allow for mapping the true retinal topography since motion artifacts are significantly reduced as compared to slower time-domain systems. Combined with Doppler Velocimetry, SDOCT also provides information on retinal blood flow dynamics. We analyzed the pulsatile nature of the bidirectional flow dynamics in an artery-vein pair for a healthy volunteer at different locations and for different blood vessel diameters. The Doppler phase shift is determined as the phase difference at the same point of adjacent depth profiles, and is integrated over the area delimited by two circles corresponding to the blood vessels location. Its temporal evolution clearly shows the blood flow pulsatile nature, the cardiac cycle, in both artery and vein. The artery is identified as having a stronger variation of the integrated phase shift. We observe that artery pulsation is always easily detectable, while vein pulsation seems to depend on the veins diameter.",
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Mujat, M, Chan, RC, Cense, B, Pierce, M, Park, H, Joo, C, Chen, TC & De Boer, JF 2006, Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT. in Proceedings of SPIE - The International Society for Optical Engineering., 607909, Proceedings of SPIE - The International Society for Optical Engineering, vol. 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, San Jose, CA, United States, 06/1/23. https://doi.org/10.1117/12.649095

Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT. / Mujat, Mircea; Chan, Raymond C.; Cense, Barry; Pierce, Mark; Park, Hyle; Joo, Chulmin; Chen, Teresa C.; De Boer, Johannes F.

Proceedings of SPIE - The International Society for Optical Engineering. 2006. 607909 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6079).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Mujat M, Chan RC, Cense B, Pierce M, Park H, Joo C et al. Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT. In Proceedings of SPIE - The International Society for Optical Engineering. 2006. 607909. (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.649095